Published in Carcinogenesis on November 01, 1997
Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci U S A (1999) 2.25
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome. Am J Hum Genet (2000) 1.57
Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis. J Inherit Metab Dis (2010) 1.40
Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov (2013) 1.27
Alcohol, cofactors and the genetics of hepatocellular carcinoma. J Gastroenterol Hepatol (2008) 1.19
Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. Hepatology (2007) 1.08
5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer. Cancer Epidemiol Biomarkers Prev (2005) 1.05
Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools. FASEB J (2009) 1.01
Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells. BMC Biol (2010) 0.95
Dietary folate deficiency blocks prostate cancer progression in the TRAMP model. Cancer Prev Res (Phila) (2011) 0.89
Increased uracil misincorporation in lymphocytes from folate-deficient rats. Br J Cancer (2000) 0.89
Folate levels modulate oncogene-induced replication stress and tumorigenicity. EMBO Mol Med (2015) 0.82
Plasma folate, vitamin B12, and homocysteine and cancers of the esophagus, stomach, and liver in a Chinese population. Nutr Cancer (2015) 0.77
Challenges identifying genetic determinants of pediatric cancers--the childhood leukemia experience. Fam Cancer (2006) 0.77
Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature. Genes Nutr (2017) 0.75
Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes (1986) 3.41
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum Mol Genet (2001) 2.93
Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem (2000) 2.60
Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr (1998) 2.36
Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi's sarcoma: results of a randomized phase III clinical trial. J Clin Oncol (1998) 2.12
Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J Nutr (2001) 1.79
A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochem Biophys Res Commun (1999) 1.77
Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr (1997) 1.75
Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. J Exp Med (1987) 1.65
Laparoscopic versus open appendectomy: prospective randomized trial. World J Surg (1996) 1.62
Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats. Cancer Res (1995) 1.60
A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection. J Nutr Biochem (1999) 1.58
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome. Am J Hum Genet (2000) 1.57
Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes. J Exp Med (1992) 1.46
The development of heart lung machines. Surg Gynecol Obstet (1982) 1.45
Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Physiol Genomics (2005) 1.43
Air-, water- and vacuum-thawing of frozen pork legs. J Sci Food Agric (1974) 1.39
Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Transl Psychiatry (2012) 1.35
Homocysteine metabolism in children with Down syndrome: in vitro modulation. Am J Hum Genet (2001) 1.34
Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat. Cancer Lett (1997) 1.29
Cerebral folate receptor autoantibodies in autism spectrum disorder. Mol Psychiatry (2012) 1.22
T cell potentiation by low dose ionizing radiation: possible mechanisms. Health Phys (1990) 1.20
Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 x C3H F1 mice. Cancer Res (1994) 1.15
Importance of eccentric actions in performance adaptations to resistance training. Aviat Space Environ Med (1991) 1.15
Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: possible in vivo relevance during tumorigenesis. Cancer Res (2000) 1.13
Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene. J Med Genet (2005) 1.13
Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology (1996) 1.13
Genetic control of diabetes and insulitis in the nonobese diabetic mouse. Pedigree analysis of a diabetic H-2nod/b heterozygote. J Immunol (1989) 1.12
Immunologic basis for susceptibility to infection in the aged. Gerontology (1984) 1.08
Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells. Cancer Lett (1999) 1.06
Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect. Am J Med Genet (2001) 1.04
Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells. Carcinogenesis (1996) 1.03
Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging. Environ Health Perspect (1998) 1.01
Redox metabolism abnormalities in autistic children associated with mitochondrial disease. Transl Psychiatry (2013) 1.00
Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice. Am J Pathol (1995) 1.00
Salmonella, Campylobacter and Escherichia coli O157:H7 decontamination techniques for the future. Int J Food Microbiol (1995) 1.00
Detection of autoantibodies to SS-A/Ro by indirect immunofluorescence using a transfected and overexpressed human 60 kD Ro autoantigen in HEp-2 cells. J Clin Lab Anal (1995) 0.97
Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats. Carcinogenesis (1997) 0.97
Canine models of ocular disease: outcross breedings define a dominant disorder present in the English mastiff and bull mastiff dog breeds. J Hered (2003) 0.96
Lipoprotein lipase: size of the functional unit determined by radiation inactivation. J Lipid Res (1983) 0.95
Quantification of 3'OH DNA breaks by random oligonucleotide-primed synthesis (ROPS) assay. DNA Cell Biol (1996) 0.95
Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion. Int J Oncol (1999) 0.94
A rapid and sensitive assay for the detection of DNA fragmentation during early phases of apoptosis. Nucleic Acids Res (1994) 0.93
In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Res (1994) 0.93
Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study. Transl Psychiatry (2013) 0.93
Kaposi sarcoma of the conjunctiva and eyelids associated with the acquired immunodeficiency syndrome. Arch Ophthalmol (1989) 0.92
Large, activated B cells are the primary B-cell target of 8-bromoguanosine and 8-mercaptoguanosine. Cell Immunol (1987) 0.92
Factors affecting the performance of 5' nuclease PCR assays for Listeria monocytogenes detection. J Microbiol Methods (2002) 0.92
Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats. Toxicol Lett (2012) 0.91
Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate. Am J Pathol (1996) 0.90
Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction. Am J Pathol (1996) 0.90
Maternal folate polymorphisms and the etiology of human nondisjunction. Am J Hum Genet (2001) 0.90
Characterization of cellular response to silicone implants in rats: implications for foreign-body carcinogenesis. Biomaterials (1997) 0.89
Mice chronically exposed to low dose ionizing radiation possess splenocytes with elevated levels of HSP70 mRNA, HSC70 and HSP72 and with an increased capacity to proliferate. Int J Radiat Biol (1993) 0.88
Life-threatening thrombotic thrombocytopenic purpura (TTP) in a patient with sickle cell-hemoglobin C disease. Ann Hematol (2003) 0.88
Chemoprevention of spontaneous tumorigenesis in nullizygous p53-deficient mice by dehydroepiandrosterone and its analog 16alpha-fluoro-5-androsten-17-one. Carcinogenesis (1997) 0.87
Iron status of female runners. Int J Sport Nutr (1993) 0.87
Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats. Carcinogenesis (1995) 0.87
Alterations in nucleotide pools in rats fed diets deficient in choline, methionine and/or folic acid. Carcinogenesis (1992) 0.87
A simplified HPLC method for simultaneously quantifying ribonucleotides and deoxyribonucleotides in cell extracts or frozen tissues. Cell Prolif (1993) 0.86
Low back disorders in agriculture and the role of stooped work: scope, potential interventions, and research needs. J Agric Saf Health (2008) 0.84
Transplantation immunity in annelids. II. Adoptive transfer of the xenograft reaction. Immunology (1971) 0.83
The effectiveness of computer-managed instruction versus traditional classroom lecture on achievement outcomes. Comput Nurs (1991) 0.82
Hypomethylation of the rat glutathione S-transferase pi (GSTP) promoter region isolated from methyl-deficient livers and GSTP-positive liver neoplasms. Carcinogenesis (1998) 0.82
Cardiorespiratory and metabolic responses to submaximal and maximal exercise in elite women distance runners. Int J Sports Med (1987) 0.82
DNA fragmentation and nuclear endonuclease activity in rat brain after severe closed head injury. Brain Res (1996) 0.81
Colonic injury: does colostomy still have a place? Injury (2001) 0.81
Non-uniformity of surface temperatures after microwave heating of poultry meat. J Microw Power Electromagn Energy (1999) 0.81
Electrical stimulation and ultra-rapid chilling of pork. Meat Sci (1984) 0.80
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency. J Inherit Metab Dis (2008) 0.80
The essentiality of folate for the maintenance of deoxynucleotide precursor pools, DNA synthesis, and cell cycle progression in PHA-stimulated lymphocytes. Environ Health Perspect (1993) 0.80
5-Halo-6-phenyl pyrimidinones and 8-substituted guanosines: biological response modifiers with similar effects on B cells. Cell Immunol (1988) 0.79
The coupling of cyclic GMP and photopolarization of Pelvetia zygotes. Dev Biol (1997) 0.79
Protective effect of magnesium on DNA strand breaks induced by nickel or cadmium. Cell Biol Toxicol (1994) 0.78
Volatile N-nitrosamines in infant pacifiers sold in the United States as determined by gas chromatography/thermal energy analysis. J Assoc Off Anal Chem (1986) 0.78
Basal cell proliferation in female SKH-1 mice treated with alpha- and beta-hydroxy acids. Toxicol Appl Pharmacol (2001) 0.78
The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats. Toxicol Appl Pharmacol (2008) 0.78
Peritoneovenous shunts--devices of last resort. Can J Surg (1988) 0.77
Congenital tracheal web--a case report. J Otolaryngol (1978) 0.77
Determination of N-nitrosamines and N-nitrosamine precursors in rubber nipples from baby pacifiers by gas chromatography-thermal energy analysis. J Toxicol Environ Health (1984) 0.77
Frostbite in Saskatoon: a review of 10 winters. Can J Surg (1980) 0.77
Cut or paste? The use of glyceryl trinitrate paste in the treatment of acute and chronic anal fissure. Aust N Z J Surg (2000) 0.77
Suicidal tendency and multiple sclerosis. Health Soc Work (1991) 0.77
Conjunctival mycobacteriosis in two emus (Dromaius novaehollandiae). Vet Pathol (1996) 0.77
[One carbon metabolism and trisomy 21: analysis of the genetic polymorphism]. Ann Biol Clin (Paris) (2002) 0.77
Dietary nucleotides: effects on cell proliferation following partial hepatectomy in rats fed NIH-31, AIN-76A, or folate/methyl-deficient diets. J Nutr (1997) 0.77
Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines. Transl Psychiatry (2015) 0.76