Published in Sci Rep on July 23, 2015
Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy (2016) 0.78
Novel Zinc(II) Complexes [Zn(atc-Et)₂] and [Zn(atc-Ph)₂]: In Vitro and in Vivo Antiproliferative Studies. Int J Mol Sci (2016) 0.77
Gemcitabine-Induced Autophagy Protects Human Lung Cancer Cells from Apoptotic Death. Lung (2016) 0.76
Soy-Based Multiple Amino Acid Oral Supplementation Increases the Anti-Sarcoma Effect of Cyclophosphamide. Nutrients (2016) 0.75
PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway. Oncotarget (2016) 0.75
Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation. Redox Biol (2017) 0.75
Autophagy and Inflammatory Response in the Tumor Microenvironment. Int J Mol Sci (2017) 0.75
Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells. PLoS One (2017) 0.75
Targeting autophagy in cancer. Nat Rev Cancer (2017) 0.75
Hypoxia-inducible factor-1α promotes endometrial stromal cells migration and invasion by upregulating autophagy in endometriosis. Reproduction (2017) 0.75
Global cancer statistics, 2002. CA Cancer J Clin (2005) 119.22
The retinoblastoma protein and cell cycle control. Cell (1995) 20.21
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst (2001) 8.57
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol (2003) 8.12
Apoptosis: a link between cancer genetics and chemotherapy. Cell (2002) 7.86
Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr (2007) 5.75
HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev (2009) 5.24
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol (2009) 4.95
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res (2001) 3.27
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol (2007) 3.10
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ (2009) 2.93
Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ (2008) 2.84
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis (2013) 2.52
pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci U S A (1998) 2.49
Hypoxia-induced autophagy: cell death or cell survival? Curr Opin Cell Biol (2009) 2.45
Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death Differ (2008) 2.45
Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells. Cancer Res (2006) 2.26
Investigating hypoxic tumor physiology through gene expression patterns. Oncogene (2003) 2.24
Apoptosis and non-apoptotic deaths in cancer development and treatment response. Cancer Treat Rev (2008) 2.20
RB-dependent S-phase response to DNA damage. Mol Cell Biol (2000) 2.08
Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Cancer Res (2011) 1.99
Tumor hypoxia and cancer progression. Cancer Lett (2005) 1.87
Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics. Autophagy (2011) 1.81
Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc Res (2005) 1.76
Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. Am J Physiol Renal Physiol (2008) 1.71
Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene. Cancer Chemother Pharmacol (2006) 1.67
AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells. J Cell Mol Med (2009) 1.67
Tumour hypoxia affects the responsiveness of cancer cells to chemotherapy and promotes cancer progression. Anticancer Agents Med Chem (2008) 1.60
Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells. Med Oncol (2009) 1.60
Inhibiting hypoxia-inducible factor 1 for cancer therapy. Mol Cancer Res (2006) 1.51
Hypoxia-inducible factor signaling in the development of tissue fibrosis. Cell Cycle (2008) 1.49
Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol (1985) (2001) 1.46
Molecular responses to hypoxia in tumor cells. Mol Cancer (2003) 1.43
Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. Autophagy (2009) 1.39
Methods for monitoring autophagy using GFP-LC3 transgenic mice. Methods Enzymol (2009) 1.37
Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1. Mol Pharmacol (2005) 1.32
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression. Cancer Res (2011) 1.25
Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation. Autophagy (2009) 1.16
Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells. Ann Surg Oncol (2009) 1.11
p53 signaling and autophagy in cancer: a revolutionary strategy could be developed for cancer treatment. Autophagy (2011) 1.04
Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells. Mol Cancer Ther (2006) 1.03
Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation. Cell Death Dis (2013) 1.00
Effects of hypoxia on human cancer cell line chemosensitivity. BMC Cancer (2013) 1.00
Cisplatin enhances the antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand gene therapy via recruitment of the mitochondria-dependent death signaling pathway. Cancer Gene Ther (2008) 0.94
Hypoxia and HIF-1alpha protect A549 cells from drug-induced apoptosis. Cell Death Differ (2006) 0.93
Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation. Cancer Res (2004) 0.92
Hypoxia-induced cisplatin resistance is reversible and growth rate independent in lung cancer cells. Cancer Lett (2011) 0.90
Role of the metabolic stress responses of apoptosis and autophagy in tumor suppression. Ernst Schering Found Symp Proc (2007) 0.90
Apoptosis of HeLa cells induced by cisplatin and its mechanism. J Huazhong Univ Sci Technolog Med Sci (2008) 0.89
Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells. Sci Rep (2014) 0.85
Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells. Int Immunopharmacol (2011) 0.85
Cisplatin-induced apoptosis inhibits autophagy, which acts as a pro-survival mechanism in human melanoma cells. PLoS One (2013) 0.84
Mechanism of cisplatin resistance in human urothelial carcinoma cells. Food Chem Toxicol (2012) 0.83
mTHPC-based photodynamic therapy induction of autophagy and apoptosis in cultured cells in relation to mitochondria and endoplasmic reticulum stress. Int J Oncol (2011) 0.81
Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro. J Cancer Res Clin Oncol (2011) 0.78
Activation of caspase-3/caspase-3-like activity in rat cardiomyocytes by an RGD peptide, but not the GPIIb/IIIa antagonist lotrafiban. Thromb Res (2001) 0.78
Adjuvant chemotherapy for completely resected non-small-cell lung cancer. Acta Med Okayama (2009) 0.78
Hypoxia down-regulates glucocorticoid receptor alpha and attenuates the anti-inflammatory actions of dexamethasone in human alveolar epithelial A549 cells. Life Sci (2009) 0.78
Chemotherapy regimens in advanced non-small-cell lung cancer: recent randomized trials. Clin Lung Cancer (2002) 0.76