Published in Behav Brain Res on July 22, 2015
The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience (2015) 0.82
The chronic mild stress (CMS) model of depression: History, evaluation and usage. Neurobiol Stress (2016) 0.80
The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant. Curr Neuropharmacol (2017) 0.78
GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine. Neuropsychopharmacology (2016) 0.78
Modulation of the activity of N-methyl-d-aspartate receptors as a novel treatment option for depression: current clinical evidence and therapeutic potential of rapastinel (GLYX-13). Neuropsychiatr Dis Treat (2017) 0.75
Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators. Neural Plast (2017) 0.75
Synaptic Plasticity, Metaplasticity and Depression. Curr Neuropharmacol (2017) 0.75
Rapid Acting Antidepressants in Chronic Stress Models: Molecular and Cellular Mechanisms. Chronic Stress (Thousand Oaks) (2017) 0.75
Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions. Psychopharmacology (Berl) (2017) 0.75
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res (2008) 54.83
The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res (2004) 54.37
Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma. Arch Gen Psychiatry (1998) 9.73
Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology (2005) 4.82
A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan War veterans. Am J Psychiatry (2014) 4.25
Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry (2011) 3.62
Ketamine use: a review. Addiction (2011) 3.56
The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat Rev Neurosci (2013) 3.36
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol (2007) 3.32
Fear extinction in rats: implications for human brain imaging and anxiety disorders. Biol Psychol (2006) 3.32
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry (2014) 2.45
A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder. Biol Psychiatry (2012) 2.12
Neural substrates mediating human delay and trace fear conditioning. J Neurosci (2004) 1.84
GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects. Neuropsychopharmacology (2012) 1.74
Implications of memory modulation for post-traumatic stress and fear disorders. Nat Neurosci (2013) 1.72
Exposure to acute stress blocks the induction of long-term potentiation of the amygdala-prefrontal cortex pathway in vivo. J Neurosci (2003) 1.50
Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD. Neuropsychopharmacology (2007) 1.30
Identification of the hippocampal input to medial prefrontal cortex in vitro. Cereb Cortex (2009) 1.28
GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator. Neuropharmacology (2005) 1.20
D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial. Neuropsychopharmacology (2013) 1.18
Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike? Psychopharmacology (Berl) (1997) 1.16
Modeling depression: social dominance-submission gene expression patterns in rat neocortex. Neuroscience (2005) 1.14
A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus. Neuropharmacology (2008) 1.12
GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists. Expert Opin Investig Drugs (2013) 1.07
The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats. Neurobiol Aging (2009) 1.05
A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression. Int J Neuropsychopharmacol (2012) 1.00
Uncovering the molecular basis of positive affect using rough-and-tumble play in rats: a role for insulin-like growth factor I. Neuroscience (2010) 0.98
Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors. Neuroscience (2011) 0.98
Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review. Ther Adv Chronic Dis (2015) 0.98
Stress and amygdala suppression of metaplasticity in the medial prefrontal cortex. Cereb Cortex (2010) 0.97
D-cycloserine into the BLA reverses the impairing effects of exposure to stress on the extinction of contextual fear, but not conditioned taste aversion. Learn Mem (2009) 0.94
Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder. J Affect Disord (2006) 0.92
A novel NMDA receptor glycine-site partial agonist, GLYX-13, has therapeutic potential for the treatment of autism. Neurosci Biobehav Rev (2011) 0.91
Social defeat, a paradigm of depression in rats that elicits 22-kHz vocalizations, preferentially activates the cholinergic signaling pathway in the periaqueductal gray. Behav Brain Res (2007) 0.90
Distinct patterns of gene expression in the left and right hippocampal formation of developing rats. Hippocampus (2006) 0.86
Gene expression patterns in hypoxic and post-hypoxic adult rat retina with special reference to the NMDA receptor and its interactome. Mol Vis (2009) 0.85
Stress-induced metaplasticity: from synapses to behavior. Neuroscience (2013) 0.85
Integrative biological analysis for neuropsychopharmacology. Neuropsychopharmacology (2013) 0.79
Regional changes in gene expression after limbic kindling. Cell Mol Neurobiol (2011) 0.78