Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators.

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Published in Neural Plast on January 09, 2017

Authors

Lulu Yao1, Qiang Zhou1

Author Affiliations

1: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

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NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature (2016) 3.18

The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments. Am J Psychiatry (2007) 2.89

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The glycinergic inhibitory synapse. Cell Mol Life Sci (2001) 2.50

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Control of NMDA receptor function by the NR2 subunit amino-terminal domain. J Neurosci (2009) 2.19

Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron (1997) 2.14

The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia. Schizophr Res (2015) 2.14

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Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study. Arch Gen Psychiatry (2005) 2.08

Triheteromeric NMDA receptors at hippocampal synapses. J Neurosci (2013) 2.01

Modulation of triheteromeric NMDA receptors by N-terminal domain ligands. Neuron (2005) 2.01

NMDA receptor structures reveal subunit arrangement and pore architecture. Nature (2014) 1.99

NMDA di-heteromeric receptor populations and associated proteins in rat hippocampus. J Neurosci (2007) 1.95

Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J Neurochem (1995) 1.79

Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Neuropharmacology (2006) 1.77

Modulation of N-methyl-D-aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones. J Physiol (1990) 1.77

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Sarcosine (N-methylglycine) treatment for acute schizophrenia: a randomized, double-blind study. Biol Psychiatry (2007) 1.73

Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists. Curr Opin Pharmacol (2005) 1.71

D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration. FEBS J (2008) 1.63

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Excitotoxicity: perspectives based on N-methyl-D-aspartate receptor subtypes. J Pharmacol Exp Ther (2002) 1.52

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Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis. Curr Pharm Des (2010) 1.44

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D-serine for the treatment of negative symptoms in individuals at clinical high risk of schizophrenia: a pilot, double-blind, placebo-controlled, randomised parallel group mechanistic proof-of-concept trial. Lancet Psychiatry (2015) 1.01

NMDA receptors in nervous system diseases. Neuropharmacology (2013) 1.00

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Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801. Psychopharmacology (Berl) (2008) 0.83

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