Published in Cell Mol Life Sci on July 28, 2015
Defective phosphoinositide metabolism in autism. J Neurosci Res (2016) 0.76
A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity. Biosci Rep (2016) 0.75
Acidic Ca(2+) stores in neurodegeneration. Messenger (Los Angel) (2016) 0.75
Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol. Proc Natl Acad Sci U S A (2017) 0.75
Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci (1991) 5.71
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol (2004) 4.60
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol (2004) 4.24
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science (1991) 4.09
Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Mol Cell (1998) 4.01
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature (2007) 3.91
Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J Cell Biol (1995) 3.16
Endosomal sorting and signalling: an emerging role for sorting nexins. Nat Rev Mol Cell Biol (2008) 3.11
Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci U S A (1988) 2.95
SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol (2011) 2.92
PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun (2010) 2.54
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A (2007) 2.41
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39
Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. Am J Hum Genet (2009) 2.22
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci (2006) 2.12
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep (2008) 2.09
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J (2008) 2.08
The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell (2009) 1.99
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell (2010) 1.98
Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve. J Biol Chem (2001) 1.88
The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochem Res (2000) 1.84
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell (2002) 1.84
PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. J Biol Chem (1999) 1.79
A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. J Cell Sci (2006) 1.79
Multivesicular bodies: co-ordinated progression to maturity. Curr Opin Cell Biol (2008) 1.45
Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein. J Neurosci (1994) 1.41
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A (2012) 1.39
PIKfyve regulation of endosome-linked pathways. Traffic (2009) 1.39
Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Mol Neurodegener (2010) 1.25
Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. J Biol Chem (2003) 1.24
Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells. Mol Cell Biol (1999) 1.22
Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs. Curr Biol (2011) 1.18
Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes. Proc Natl Acad Sci U S A (2006) 1.17
The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport. Neurobiol Dis (2012) 1.14
Cargo selection in vesicular transport: the making and breaking of a coat. Traffic (2002) 1.13
Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects. Endocrinology (2002) 1.10
Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance. Bioessays (2013) 1.10
Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics. Proc Natl Acad Sci U S A (2013) 1.09
Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling. Bioessays (2013) 1.06
Functions of the APP gene family in the nervous system: insights from mouse models. Exp Brain Res (2011) 1.05
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling. Chem Biol (2013) 1.02
Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes. Prog Lipid Res (2007) 1.02
Segmentation and quantification of subcellular structures in fluorescence microscopy images using Squassh. Nat Protoc (2014) 1.02
Amyloid precursor protein and neural development. Development (2014) 0.99
Segregation of a missense mutation in the amyloid beta-protein precursor gene with familial Alzheimer's disease. J Alzheimers Dis (2006) 0.99
PIKfyve and its Lipid products in health and in sickness. Curr Top Microbiol Immunol (2012) 0.98
Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin. J Biol Chem (2008) 0.96
Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease. J Biol Chem (2013) 0.94
Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression. Proc Natl Acad Sci U S A (2014) 0.85
The role of APP and BACE1 trafficking in APP processing and amyloid-β generation. Alzheimers Res Ther (2013) 0.83
Liposome-based assays to study membrane-associated protein networks. Methods Enzymol (2014) 0.78