Published in Nat Commun on July 13, 2010
Endosome maturation. EMBO J (2011) 5.22
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell (2013) 2.31
The transient receptor potential family of ion channels. Genome Biol (2011) 2.08
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol (2015) 1.88
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nat Commun (2012) 1.85
Autophagy in lysosomal storage disorders. Autophagy (2012) 1.59
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases. EMBO J (2014) 1.43
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A (2012) 1.39
A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis. Dev Cell (2013) 1.36
Lysosomal physiology. Annu Rev Physiol (2015) 1.34
Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J. PLoS Genet (2011) 1.27
Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity. Sci Rep (2011) 1.18
Phosphoinositides and vesicular membrane traffic. Biochim Biophys Acta (2012) 1.14
Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration. Hum Mol Genet (2012) 1.13
Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance. Bioessays (2013) 1.10
Phosphoinositides regulate ion channels. Biochim Biophys Acta (2014) 1.09
Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. EMBO J (2015) 1.09
Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics. Proc Natl Acad Sci U S A (2013) 1.09
Acidic calcium stores of Saccharomyces cerevisiae. Cell Calcium (2011) 1.09
Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum. J Cell Sci (2012) 1.08
Drosophila TRPML is required for TORC1 activation. Curr Biol (2012) 1.06
Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification. Cell Rep (2015) 1.03
AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Sci Signal (2013) 1.03
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation. Nat Cell Biol (2016) 1.02
Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate. Plant Cell (2013) 1.01
The role of TRPMLs in endolysosomal trafficking and function. Cell Calcium (2014) 0.99
The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation. Proc Natl Acad Sci U S A (2014) 0.99
Lipid sorting and multivesicular endosome biogenesis. Cold Spring Harb Perspect Biol (2013) 0.98
Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4. J Neurosci (2011) 0.98
Role of TRP channels in the regulation of the endosomal pathway. Physiology (Bethesda) (2011) 0.98
Phosphoinositide regulation of TRP channels. Handb Exp Pharmacol (2014) 0.97
The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels. Cell Calcium (2011) 0.97
Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P. EMBO J (2012) 0.97
Lysosomal exocytosis and lipid storage disorders. J Lipid Res (2014) 0.97
Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites. PLoS One (2011) 0.95
The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy. Nat Med (2014) 0.94
The signaling lipid PI(3,5)P₂ stabilizes V₁-V(o) sector interactions and activates the V-ATPase. Mol Biol Cell (2014) 0.92
A lipid switch unlocks Parkinson's disease-associated ATP13A2. Proc Natl Acad Sci U S A (2015) 0.91
P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH. J Biol Chem (2014) 0.91
Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. J Biol Chem (2013) 0.90
Reactivation of Lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells. J Neurosci (2015) 0.89
Cellular and molecular interactions of phosphoinositides and peripheral proteins. Chem Phys Lipids (2014) 0.89
Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter. Biochem J (2013) 0.89
SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability. J Biol Chem (2014) 0.89
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun (2016) 0.89
Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis. J Biol Chem (2012) 0.88
Role of TRP channels in the cardiovascular system. Am J Physiol Heart Circ Physiol (2014) 0.88
TRPML: transporters of metals in lysosomes essential for cell survival? Cell Calcium (2011) 0.88
Zn2+ efflux through lysosomal exocytosis prevents Zn2+-induced toxicity. J Cell Sci (2014) 0.88
Phosphoinositides in the mammalian endo-lysosomal network. Subcell Biochem (2012) 0.87
Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes. J Physiol (2013) 0.87
Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation. Proc Natl Acad Sci U S A (2015) 0.87
Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death. PLoS One (2013) 0.87
Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV. EMBO Rep (2015) 0.85
Organellar channels and transporters. Cell Calcium (2015) 0.84
Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules. J Biol Chem (2012) 0.84
Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies. Handb Exp Pharmacol (2014) 0.84
Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion. J Cell Biol (2015) 0.84
Endosomal maturation, Rab7 GTPase and phosphoinositides in African swine fever virus entry. PLoS One (2012) 0.84
Transient receptor potential (TRP) channels and cardiac fibrosis. Curr Top Med Chem (2013) 0.84
Mouse models of PI(3,5)P2 deficiency with impaired lysosome function. Methods Enzymol (2014) 0.83
Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling. J Biol Chem (2014) 0.83
The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole. J Biol Chem (2015) 0.83
PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment. Dev Cell (2016) 0.82
Two-pore channels at the intersection of endolysosomal membrane traffic. Biochem Soc Trans (2015) 0.82
Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function. J Biol Chem (2013) 0.82
A non-inactivating high-voltage-activated two-pore Na⁺ channel that supports ultra-long action potentials and membrane bistability. Nat Commun (2014) 0.82
Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol (2014) 0.81
Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. Cell Rep (2015) 0.81
Ca²⁺-sensor proteins in the autophagic and endocytic traffic. Curr Protein Pept Sci (2013) 0.81
Biallelic Mutations of VAC14 in Pediatric-Onset Neurological Disease. Am J Hum Genet (2016) 0.80
Fig4 deficiency: a newly emerged lysosomal storage disorder? Prog Neurobiol (2012) 0.80
Mucolipin co-deficiency causes accelerated endolysosomal vacuolation of enterocytes and failure-to-thrive from birth to weaning. PLoS Genet (2014) 0.80
Molecular bases of multimodal regulation of a fungal transient receptor potential (TRP) channel. J Biol Chem (2013) 0.80
FIG4 regulates lysosome membrane homeostasis independent of phosphatase function. Hum Mol Genet (2015) 0.80
A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol (2015) 0.79
Identification and analysis of cation channel homologues in human pathogenic fungi. PLoS One (2012) 0.79
Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV. Dis Model Mech (2015) 0.79
Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. PLoS One (2014) 0.79
Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time. Biochem Soc Trans (2016) 0.79
Targeting TRPM2 in ROS-Coupled Diseases. Pharmaceuticals (Basel) (2016) 0.78
Cyclic ADP-Ribose and NAADP in Vascular Regulation and Diseases. Messenger (Los Angel) (2013) 0.78
Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue. Mol Microbiol (2013) 0.78
Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene. Hum Mol Genet (2015) 0.78
The Amyloid Precursor Protein Controls PIKfyve Function. PLoS One (2015) 0.78
Calcium signaling in membrane repair. Semin Cell Dev Biol (2015) 0.78
Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection. Traffic (2014) 0.78
Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx. J Cell Sci (2016) 0.78
Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1. Cell Calcium (2014) 0.78
Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun Integr Biol (2012) 0.78
A melanosomal two-pore sodium channel regulates pigmentation. Sci Rep (2016) 0.77
How does NAADP release lysosomal Ca2+? Channels (Austin) (2014) 0.77
The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function. Pflugers Arch (2015) 0.77
Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression. Oncotarget (2016) 0.77
Identification of a membrane-targeting domain of the transient receptor potential canonical (TRPC)4 channel unrelated to its formation of a tetrameric structure. J Biol Chem (2014) 0.77
APP controls the formation of PI(3,5)P2 vesicles through its binding of the PIKfyve complex. Cell Mol Life Sci (2015) 0.77
Two-Pore Channels: Lessons from Mutant Mouse Models. Messenger (Los Angel) (2015) 0.77
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
Lysosomes: fusion and function. Nat Rev Mol Cell Biol (2007) 5.74
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature (2009) 4.41
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature (2007) 3.91
PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89
Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion. Nature (1998) 3.33
Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. J Cell Biol (1998) 3.24
A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell (2009) 2.77
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature (2008) 2.76
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J Cell Biol (2002) 2.52
Phosphoinositides in constitutive membrane traffic. Physiol Rev (2004) 2.45
Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel. Hum Mol Genet (2000) 2.43
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A (2007) 2.41
Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6. Mol Cell (2007) 2.33
Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis. Proc Natl Acad Sci U S A (2004) 2.28
Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. Am J Hum Genet (2009) 2.22
Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell (2003) 2.19
Abnormal transport along the lysosomal pathway in mucolipidosis, type IV disease. Proc Natl Acad Sci U S A (1998) 2.18
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J (2008) 2.08
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A (2007) 1.99
The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae. Curr Biol (1998) 1.95
Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic. Traffic (2006) 1.92
Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis. Nat Cell Biol (2009) 1.92
A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. Proc Natl Acad Sci U S A (2007) 1.91
Transient receptor potential channels meet phosphoinositides. EMBO J (2008) 1.89
The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. J Cell Biol (2006) 1.86
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2. Hum Mol Genet (2009) 1.84
Internal Ca(2+) release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue. J Cell Biol (2002) 1.79
Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function. Biochem J (2009) 1.78
Phosphoinositide 5-phosphatase Fig 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels. Eukaryot Cell (2006) 1.69
A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca(2+)-permeable channel in the yeast vacuolar membrane. Proc Natl Acad Sci U S A (2001) 1.63
Mucolipins: Intracellular TRPML1-3 channels. FEBS Lett (2010) 1.49
The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic (2009) 1.44
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase. Mol Biol Cell (2008) 1.40
Calcium: a fundamental regulator of intracellular membrane fusion? EMBO Rep (2007) 1.32
Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem (2009) 1.32
TRP channels of intracellular membranes. J Neurochem (2010) 1.30
Role of the V-ATPase in regulation of the vacuolar fission-fusion equilibrium. Mol Biol Cell (2007) 1.28
Lysosomal trafficking functions of mucolipin-1 in murine macrophages. BMC Cell Biol (2007) 1.27
TRPMLs: in sickness and in health. Am J Physiol Renal Physiol (2009) 1.26
The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis. EMBO Rep (2005) 1.26
TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP. FEBS Lett (2010) 1.26
A potentially dynamic lysosomal role for the endogenous TRPML proteins. J Pathol (2009) 1.09
Phosphatidylinositol metabolism and membrane fusion. Biochem J (2009) 1.06
Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1. J Biol Chem (2009) 0.99
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
An introduction to TRP channels. Annu Rev Physiol (2006) 7.52
Are American children and adolescents of low socioeconomic status at increased risk of obesity? Changes in the association between overweight and family income between 1971 and 2002. Am J Clin Nutr (2006) 4.78
A mammalian organelle map by protein correlation profiling. Cell (2006) 4.54
Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem (2004) 4.27
In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): production and activity of an AMA1 vaccine and generation of a multiallelic response. Infect Immun (2002) 4.02
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature (2007) 3.91
The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol (2006) 3.79
Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. Nature (2008) 3.28
Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res (2011) 3.25
Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol (2005) 3.12
TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum. Nat Genet (2011) 3.06
Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron (2008) 2.98
Identifying the proteins to which small-molecule probes and drugs bind in cells. Proc Natl Acad Sci U S A (2009) 2.94
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature (2008) 2.76
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci (2006) 2.58
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J Cell Biol (2002) 2.52
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci (2004) 2.41
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A (2007) 2.41
Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano (2012) 2.35
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell (2010) 2.32
Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. Am J Hum Genet (2009) 2.22
A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol (2009) 2.21
Fused whole-heart coronary and myocardial scar imaging using 3-T CMR. Implications for planning of cardiac resynchronization therapy and coronary revascularization. JACC Cardiovasc Imaging (2010) 2.17
Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J Immunol (2006) 2.15
The cost-effectiveness of improving diabetes care in U.S. federally qualified community health centers. Health Serv Res (2007) 2.09
The effect of comorbid illness and functional status on the expected benefits of intensive glucose control in older patients with type 2 diabetes: a decision analysis. Ann Intern Med (2008) 2.08
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J (2008) 2.08
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A (2007) 1.99
Duct-to-mucosa versus invagination pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis. Chin Med J (Engl) (2013) 1.99
Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science (2011) 1.97
Structural basis for myosin V discrimination between distinct cargoes. EMBO J (2006) 1.95
Spontaneous spinal epidural hematoma: analysis of 23 cases. Surg Neurol (2007) 1.94
Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chem Biol (2009) 1.93
Analysis of the mouse liver proteome using advanced mass spectrometry. J Proteome Res (2007) 1.93
Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev (2013) 1.91
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol (2015) 1.88
Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients. Biol Psychiatry (2011) 1.87
NMNAT1 mutations cause Leber congenital amaurosis. Nat Genet (2012) 1.86
The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. J Cell Biol (2006) 1.86
Processing pathway dependence of amorphous silica nanoparticle toxicity: colloidal vs pyrolytic. J Am Chem Soc (2012) 1.86
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nat Commun (2012) 1.85
Dispersion and stability optimization of TiO2 nanoparticles in cell culture media. Environ Sci Technol (2010) 1.84
Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. Carcinogenesis (2012) 1.84
Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell (2002) 1.84
A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem (2003) 1.84
Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression. Hepatology (2015) 1.81
Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J Cell Biol (2003) 1.81
MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Nucleic Acids Res (2011) 1.79
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Nat Genet (2012) 1.78
TRP ion channels in the nervous system. Curr Opin Neurobiol (2004) 1.78
Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos. ACS Nano (2011) 1.75
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab (2005) 1.72
The increasing number of clinical items addressed during the time of adult primary care visits. J Gen Intern Med (2008) 1.72
A recombinant vaccine expressed in the milk of transgenic mice protects Aotus monkeys from a lethal challenge with Plasmodium falciparum. Proc Natl Acad Sci U S A (2001) 1.71
Phosphoinositide 5-phosphatase Fig 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels. Eukaryot Cell (2006) 1.69
Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials. ACS Nano (2011) 1.68
Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium. Environ Health Perspect (2013) 1.68
Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron (2010) 1.66
Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. Toxicol Lett (2008) 1.61
Glycated albumin is superior to hemoglobin A1c for evaluating the presence and severity of coronary artery disease in type 2 diabetic patients. Cardiology (2012) 1.59
Identification of an organelle-specific myosin V receptor. J Cell Biol (2003) 1.57
An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells. J Immunol (2010) 1.57
Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol (2009) 1.56
Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res (2012) 1.56
Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol (2002) 1.55
c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. J Neurosci (2006) 1.55
Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses. J Neurosci (2004) 1.53
The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation. DNA Repair (Amst) (2008) 1.51
Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex. Dev Cell (2011) 1.50
JAK2(V617F): Prevalence in a large Chinese hospital population. Blood (2006) 1.50
Mucolipins: Intracellular TRPML1-3 channels. FEBS Lett (2010) 1.49
Direct ambulance transport to catheterization laboratory reduces door-to-balloon time in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the DIRECT-STEMI study. Chin Med J (Engl) (2011) 1.49
Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity. ACS Nano (2013) 1.47
Insights into the activity, differential expression, mutual regulation, and functions of matrix metalloproteinases and a disintegrin and metalloproteinases in hypertension and cardiac disease. J Vasc Res (2012) 1.46
Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesis. Cardiovasc Res (2009) 1.46
O/C and OM/OC ratios of primary, secondary, and ambient organic aerosols with high-resolution time-of-flight aerosol mass spectrometry. Environ Sci Technol (2008) 1.46
A photoprotection strategy for microsecond-resolution single-molecule fluorescence spectroscopy. Nat Methods (2011) 1.46
Replication of a genome-wide association study of birth weight in preterm neonates. J Pediatr (2011) 1.45
Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion. Mol Biol Cell (2008) 1.45
In-depth analysis of the adipocyte proteome by mass spectrometry and bioinformatics. Mol Cell Proteomics (2007) 1.45
The effect of temperature on exhaled breath condensate collection. J Breath Res (2012) 1.45
Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature (2003) 1.45
microRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer. Oncol Rep (2011) 1.44
Interaction study of MADS-domain proteins in tomato. J Exp Bot (2008) 1.43
Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients. Atherosclerosis (2008) 1.43
Exploring one-state downhill protein folding in single molecules. Proc Natl Acad Sci U S A (2011) 1.42
Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts. J Cell Biol (2002) 1.41