Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways.

PubWeight™: 1.51‹?› | Rank: Top 4%

🔗 View Article (PMC 4526660)

Published in PLoS One on August 05, 2015

Authors

Wei-Ru Huang1, Hung-Chuan Chiu1, Tsai-Ling Liao2, Kuo-Pin Chuang3, Wing-Ling Shih4, Hung-Jen Liu5

Author Affiliations

1: Institute of Molecular Biology, National Chung Hsing University, Taichung, 402, Taiwan.
2: Department of Medical Research, Taichung Veterans General Hospital, Taichung, 402, Taiwan.
3: Graduate Institute of Animal Vaccine Technology, National Pingtung University of Science and Technology, Pingtung, 912, Taiwan.
4: Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung, 912, Taiwan.
5: Institute of Molecular Biology, National Chung Hsing University, Taichung, 402, Taiwan; Agricultural Biotechnology Center, National Chung Hsing University, Taichung, 402, Taiwan; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, 402, Taiwan.

Articles cited by this

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99

TOR signaling in growth and metabolism. Cell (2006) 35.29

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature (1996) 26.30

Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev (1998) 12.55

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A (1999) 11.38

Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature (2000) 8.35

The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene (2004) 7.92

Tricine-SDS-PAGE. Nat Protoc (2006) 7.89

One-thousand-and-one substrates of protein kinase CK2? FASEB J (2003) 6.89

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol (2001) 6.43

Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62

Regulation of PTEN transcription by p53. Mol Cell (2001) 5.44

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20

Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer (2009) 5.12

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J (1996) 4.55

Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science (1988) 4.54

Dynamic nuclear pore complexes: life on the edge. Cell (2006) 4.53

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J Biol Chem (2001) 4.00

Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci U S A (2010) 3.81

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science (2007) 3.75

Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ (2006) 3.53

Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle (2008) 3.37

Retracted Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem (2002) 2.97

Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol (2000) 2.84

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83

Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science (2004) 2.81

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol (2001) 2.71

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev (2006) 2.66

The nuclear affairs of PTEN. J Cell Sci (2008) 2.34

Understanding PTEN regulation: PIP2, polarity and protein stability. Oncogene (2008) 2.07

Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. Mol Biol Cell (2004) 2.05

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells. Mol Cell Biol (2001) 1.98

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model. Hum Mol Genet (2001) 1.87

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene (2002) 1.87

Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1. Oncogene (2007) 1.81

Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. J Cell Biol (2002) 1.79

Nucleocytoplasmic transport of proteins. Biochemistry (Mosc) (2007) 1.71

From Tpr-Met to Met, tumorigenesis and tubes. Oncogene (2007) 1.69

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle (2009) 1.68

Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt. J Virol (2002) 1.67

A new class of fusion-associated small transmembrane (FAST) proteins encoded by the non-enveloped fusogenic reoviruses. EMBO J (2000) 1.66

Activation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replication. J Virol (2005) 1.57

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J Biol Chem (2002) 1.56

The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway. J Virol (2004) 1.51

Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell (2009) 1.48

How do small GTPase signal transduction pathways regulate cell cycle entry? Curr Opin Cell Biol (1999) 1.47

A role for autophagolysosomes in dengue virus 3 production in HepG2 cells. J Gen Virol (2009) 1.42

p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation. Oncogene (2007) 1.38

The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem (2001) 1.35

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Blood (2009) 1.19

PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway. Hum Mol Genet (2002) 1.11

Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis. J Biol Chem (2010) 1.10

Sequential partially overlapping gene arrangement in the tricistronic S1 genome segments of avian reovirus and Nelson Bay reovirus: implications for translation initiation. J Virol (2002) 1.10

The second open reading frame of the avian reovirus S1 gene encodes a transcription-dependent and CRM1-independent nucleocytoplasmic shuttling protein. J Virol (2005) 1.05

Regulation of autophagy by nucleoporin Tpr. Sci Rep (2012) 1.02

Nucleotide sequence analysis of human tpr cDNA clones. Oncogene (1992) 1.02

Divergent roles of autophagy in virus infection. Cells (2013) 1.01

Avian reovirus sigmaC protein induces apoptosis in cultured cells. Virology (2004) 1.01

Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis. J Cell Biol (2013) 1.00

The p17 nonstructural protein of avian reovirus triggers autophagy enhancing virus replication via activation of phosphatase and tensin deleted on chromosome 10 (PTEN) and AMP-activated protein kinase (AMPK), as well as dsRNA-dependent protein kinase (PKR)/eIF2α signaling pathways. J Biol Chem (2012) 1.00

The RhoA-ROCK-PTEN pathway as a molecular switch for anchorage dependent cell behavior. Biomaterials (2012) 0.99

PI3K-Akt signaling and viral infection. Recent Pat Biotechnol (2008) 0.98

Modification of late membrane permeability in avian reovirus-infected cells: viroporin activity of the S1-encoded nonstructural p10 protein. J Biol Chem (2002) 0.95

A jumbo problem: mapping the structure and functions of the nuclear pore complex. Curr Opin Cell Biol (2012) 0.94

Identification and serological differentiation of several reovirus strains isolated from chickens with suspected malabsorption syndrome. Avian Dis (1983) 0.93

Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model. Nucleic Acids Res (2000) 0.93

Proteasome inhibition reduces avian reovirus replication and apoptosis induction in cultured cells. J Virol Methods (2008) 0.93

Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells. PLoS One (2011) 0.91

Differential regulation of Akt/protein kinase B isoforms during cell cycle progression. FEBS Lett (2009) 0.90

Retardation of cell growth by avian reovirus p17 through the activation of p53 pathway. Biochem Biophys Res Commun (2005) 0.89

Modulation of p53 by mitogen-activated protein kinase pathways and protein kinase C delta during avian reovirus S1133-induced apoptosis. Virology (2009) 0.89

AMP-activated protein kinase facilitates avian reovirus to induce mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 3/6 signalling that is beneficial for virus replication. J Gen Virol (2009) 0.88

Evidence for the multimeric nature and cell binding ability of avian reovirus sigma 3 protein. J Gen Virol (1996) 0.88

Infectious tenosynovitis (viral arthritis): influence of maternal antibodies on the development of tenosynovitis lesions after experimental infection by day-old chickens with tenosynovitis virus. Avian Dis (1977) 0.84

Avian reovirus S1133-induced DNA damage signaling and subsequent apoptosis in cultured cells and in chickens. Arch Virol (2011) 0.83

Activation of small GTPases RhoA and Rac1 is required for avian reovirus p10-induced syncytium formation. Mol Cells (2008) 0.83

Avian reovirus influences phosphorylation of several factors involved in host protein translation including eukaryotic translation elongation factor 2 (eEF2) in Vero cells. Biochem Biophys Res Commun (2009) 0.81

Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A. Cell Cycle (2015) 0.80