Published in Mol Cell Biol on August 01, 2001
p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer (2009) 9.21
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol (2004) 5.46
Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal (2010) 2.44
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol Cell Biol (2006) 2.01
p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint. Mol Cell Biol (2009) 1.88
14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J (2004) 1.75
Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors. Cell Cycle (2010) 1.74
Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design. Proc Natl Acad Sci U S A (2005) 1.57
Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity. J Cell Biol (2002) 1.54
The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. Int J Cell Biol (2010) 1.51
Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways. PLoS One (2015) 1.51
Akt: a double-edged sword in cell proliferation and genome stability. J Oncol (2012) 1.44
Structural comparisons of class I phosphoinositide 3-kinases. Nat Rev Cancer (2008) 1.42
Glycogen synthase kinase 3beta phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation. Mol Cell Biol (2007) 1.32
Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4. Mol Cell Biol (2008) 1.27
Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts. J Biol Chem (2005) 1.22
Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum. Ann N Y Acad Sci (2012) 1.22
Akt2, a novel functional link between p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in myogenesis. Mol Cell Biol (2004) 1.18
Specific function of phosphoinositide 3-kinase beta in the control of DNA replication. Proc Natl Acad Sci U S A (2009) 1.17
Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice. J Clin Invest (2009) 1.13
Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. Oncogene (2012) 1.13
Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model. PLoS One (2010) 1.12
Regulation of angiogenesis by vascular endothelial growth factor and angiopoietin-1 in the rat aorta model: distinct temporal patterns of intracellular signaling correlate with induction of angiogenic sprouting. Am J Pathol (2002) 1.09
Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc Res (2009) 1.09
E7 abolishes raf-induced arrest via mislocalization of p21(Cip1). Mol Cell Biol (2002) 1.09
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein. EMBO J (2002) 1.08
Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21Cip1. Mol Cell Biol (2009) 1.06
Proteomic analysis of the balance between survival and cell death responses in cisplatin-mediated ototoxicity. J Proteome Res (2008) 1.06
Regulation of CDK4. Cell Div (2006) 1.06
Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest. Mol Cell Biol (2006) 1.05
PI3Kinase signaling in glioblastoma. J Neurooncol (2010) 1.01
Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation. Mol Cell Biol (2011) 0.98
Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process. Protein Sci (2002) 0.97
Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation. Mol Cell Biol (2004) 0.95
A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design. Oncogene (2006) 0.95
COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs. Front Oncol (2013) 0.94
Role of AKT signaling in DNA repair and clinical response to cancer therapy. Neuro Oncol (2014) 0.94
Cardiac progenitor cell commitment is inhibited by nuclear Akt expression. Circ Res (2011) 0.92
Translocation of p21(Cip1/WAF1) from the nucleus to the cytoplasm correlates with pancreatic myofibroblast to fibroblast cell conversion. Gut (2005) 0.91
Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance. Mol Cancer (2007) 0.91
The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1. Cell Death Dis (2013) 0.89
Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A (2008) 0.89
Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells. Int J Biochem Cell Biol (2010) 0.88
Signal transduction in cancer. Cold Spring Harb Perspect Med (2015) 0.88
Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. J Biol Chem (2010) 0.88
p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker. Mol Cancer (2010) 0.87
Targeting the insulin-like growth factor pathway in hepatocellular carcinoma. World J Hepatol (2014) 0.87
PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway in esophageal cancer in Chinese patients. Acta Pharmacol Sin (2013) 0.86
Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner. Cell Signal (2007) 0.86
Glioma is formed by active Akt1 alone and promoted by active Rac1 in transgenic zebrafish. Neuro Oncol (2013) 0.85
Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity. Am J Physiol Renal Physiol (2011) 0.85
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry. Oncotarget (2015) 0.85
MiR-375 promotes redifferentiation of adult human β cells expanded in vitro. PLoS One (2015) 0.84
Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis. PLoS One (2014) 0.84
Intracerebral transplantation for neurological disorders. Lessons from developmental, experimental, and clinical studies. Front Cell Neurosci (2012) 0.84
Modelling mammalian cellular quiescence. Interface Focus (2014) 0.82
Somatostatin receptor 1, a novel EBV-associated CpG hypermethylated gene, contributes to the pathogenesis of EBV-associated gastric cancer. Br J Cancer (2013) 0.81
CD43 promotes cells transformation by preventing merlin-mediated contact inhibition of growth. PLoS One (2013) 0.80
9-Aminoacridine inhibition of HIV-1 Tat dependent transcription. Virol J (2009) 0.80
Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function. J Biomed Sci (2010) 0.80
Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Epigenetics (2015) 0.79
Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21WAF1/CIP1 activation. Int J Oncol (2016) 0.78
A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioning. J Cereb Blood Flow Metab (2013) 0.78
Differential regulation of cyclin-dependent kinase inhibitors in neuroblastoma cells. Biochem Biophys Res Commun (2013) 0.78
Recruitment of trimeric proliferating cell nuclear antigen by G1-phase cyclin-dependent kinases following DNA damage with platinum-based antitumour agents. Br J Cancer (2013) 0.78
The efficacy of trastuzumab in Her-2/neu-overexpressing metastatic breast cancer is independent of p53 status. J Cancer Res Clin Oncol (2005) 0.77
Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. Oncotarget (2015) 0.77
Expression of CDKN1A/p21 and TGFBR2 in breast cancer and their prognostic significance. Int J Clin Exp Pathol (2015) 0.76
Activation of AKT pathway by Nrf2/PDGFA feedback loop contributes to HCC progression. Oncotarget (2016) 0.76
The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development. FEBS J (2015) 0.76
SCFFbl12 Increases p21Waf1/Cip1 Expression Level through Atypical Ubiquitin Chain Synthesis. Mol Cell Biol (2016) 0.75
Galectin-1 is essential for efficient liver regeneration following hepatectomy. Oncotarget (2016) 0.75
Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy. World J Gastroenterol (2015) 0.75
AKT and its related molecular feature in aged mice skin. PLoS One (2017) 0.75
Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation. Cell Commun Signal (2015) 0.75
Familial Alzheimer's Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants. Mol Neurobiol (2016) 0.75
Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. PLoS One (2017) 0.75
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