Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice.

TP53 mutations in newly diagnosed acute myeloid leukemia: Clinicomolecular characteristics, response to therapy, and outcomes. Cancer (2016) 0.79

The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage. Oncogene (2016) 0.75

Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42

Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007) 16.95

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science (1990) 16.68

Cancer. p53, guardian of the genome. Nature (1992) 16.36

Restoration of p53 function leads to tumour regression in vivo. Nature (2007) 12.62

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (1995) 10.18

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet (2001) 9.55

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell (2004) 8.48

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature (1991) 7.49

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci U S A (1997) 7.42

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell (2004) 7.22

Modeling the therapeutic efficacy of p53 restoration in tumors. Cell (2006) 5.95

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med (2004) 5.48

The intestinal stem cell. Genes Dev (2008) 4.21

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A (2008) 4.07

The intestinal epithelial stem cell. Bioessays (2002) 3.82

Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Natl Acad Sci U S A (1996) 3.38

Cre-mediated chromosome loss in mice. Nat Genet (1997) 3.36

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res (1994) 3.28

Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families. Cancer Res (1994) 3.20

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes Dev (2008) 3.17

Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol (2011) 2.72

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell (2008) 2.68

The role of mutant p53 in human cancer. J Pathol (2010) 2.49

Cellular inheritance of a Cre-activated reporter gene to determine Paneth cell longevity in the murine small intestine. Dev Dyn (2005) 2.46

p53 in tumour pathology: can we trust immunohistochemistry?--Revisited! J Pathol (1994) 2.41

Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine. Radiat Res (2004) 2.39

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene (2004) 2.34

Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis. Gastroenterology (2005) 1.93

The Li-Fraumeni syndrome (LFS): a model for the initiation of p53 signatures in the distal Fallopian tube. J Pathol (2010) 1.70

Regulation of ES cell differentiation by functional and conformational modulation of p53. EMBO J (1997) 1.70

Problems with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation. Br J Cancer (1994) 1.37

Multiple stress signals activate mutant p53 in vivo. Cancer Res (2011) 1.27

Regulation of p53 stability and function in HCT116 colon cancer cells. J Biol Chem (2003) 1.27

Kinetics and possible regulation of crypt cell populations under normal and stress conditions. Bull Cancer (1976) 1.20

The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Genes Dev (2013) 1.11

Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo. Cancer Cell (2012) 1.02

Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility? J Pathol (2003) 0.94

Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish. Oncogene (2012) 0.93

Gastrointestinal stem cells in self-renewal and cancer. J Gastroenterol (2011) 0.90

Adverse effects of drugs on small intestine and colon. Best Pract Res Clin Gastroenterol (2010) 0.90

MDM4 downregulates p53 transcriptional activity and response to stress during differentiation. Cell Cycle (2011) 0.89

Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish. Oncogene (2015) 0.78

Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays. Sci Rep (2015) 0.82

The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumorigenesis. J Pathol (2016) 0.75

TNBC invasion: downstream of STAT3. Oncotarget (2017) 0.75