Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

PubWeight™: 9.55‹?› | Rank: Top 0.1%

🔗 View Article (PMID 11694875)

Published in Nat Genet on December 01, 2001

Authors

J Jonkers1, R Meuwissen, H van der Gulden, H Peterse, M van der Valk, A Berns

Author Affiliations

1: Division of Molecular Genetics and Centre of Biomedical Genetics, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

Articles citing this

(truncated to the top 100)

Guidelines for the welfare and use of animals in cancer research. Br J Cancer (2010) 6.97

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell (2008) 6.88

Subtypes of medulloblastoma have distinct developmental origins. Nature (2010) 5.94

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol (2010) 5.59

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature (2008) 5.00

Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature (2009) 4.93

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A (2008) 4.61

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell (2013) 4.58

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat Protoc (2009) 4.50

p53 status determines the role of autophagy in pancreatic tumour development. Nature (2013) 4.31

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev (2009) 4.21

BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer (2011) 3.85

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A (2007) 3.58

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet (2013) 3.51

Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell (2009) 3.37

Suppression of lung adenocarcinoma progression by Nkx2-1. Nature (2011) 3.27

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet (2014) 3.17

TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A (2009) 3.08

Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev (2004) 2.91

Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell (2011) 2.87

Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. J Exp Med (2012) 2.85

Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. Cancer Cell (2013) 2.81

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74

Rb regulates fate choice and lineage commitment in vivo. Nature (2010) 2.60

Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell (2011) 2.56

Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell (2010) 2.54

Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene (2005) 2.50

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci U S A (2007) 2.39

Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell (2011) 2.38

Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status. J Clin Invest (2010) 2.38

The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol (2008) 2.34

Nuclear factor I/B is an oncogene in small cell lung cancer. Genes Dev (2011) 2.29

Identifying the cellular origin of squamous skin tumors. Proc Natl Acad Sci U S A (2011) 2.24

Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A (2007) 2.17

Ras activity levels control the development of pancreatic diseases. Gastroenterology (2009) 2.17

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature (2014) 2.15

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev (2012) 2.10

Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell (2009) 2.08

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med (2015) 2.05

Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma. Mol Cell (2013) 2.05

Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis. Genes Dev (2004) 2.04

Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice. Nat Med (2017) 2.02

20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer (2009) 2.00

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98

Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proc Natl Acad Sci U S A (2008) 1.98

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev (2010) 1.95

MDM4 is a key therapeutic target in cutaneous melanoma. Nat Med (2012) 1.93

DNA-damage repair; the good, the bad, and the ugly. EMBO J (2008) 1.89

Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A (2014) 1.89

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet (2006) 1.86

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metab (2016) 1.85

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. Cancer Cell (2014) 1.84

Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation. Cancer Cell (2014) 1.84

A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages. Development (2010) 1.83

Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma. Cancer Res (2012) 1.83

Defining the origins of Ras/p53-mediated squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 1.83

Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis. Cancer Res (2010) 1.78

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Nature (2014) 1.75

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature (2015) 1.75

Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Cold Spring Harb Perspect Biol (2015) 1.73

Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer (2009) 1.72

Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras. J Pathol (2011) 1.72

mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation. Cancer Cell (2015) 1.70

Inactivation of Brca2 promotes Trp53-associated but inhibits KrasG12D-dependent pancreatic cancer development in mice. Gastroenterology (2011) 1.70

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells. Nat Commun (2015) 1.67

VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting. Proc Natl Acad Sci U S A (2011) 1.67

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev (2010) 1.66

An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest (2007) 1.64

Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice. J Clin Invest (2010) 1.64

Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature (2016) 1.63

Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood. Development (2009) 1.59

PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol (2013) 1.55

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin. Cancer Cell (2016) 1.55

Strategies to achieve conditional gene mutation in mice. Cold Spring Harb Protoc (2014) 1.54

Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data. Nucleic Acids Res (2008) 1.52

Bcl11a is essential for lymphoid development and negatively regulates p53. J Exp Med (2012) 1.51

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell (2012) 1.49

Obligate progression precedes lung adenocarcinoma dissemination. Cancer Discov (2014) 1.47

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med (2008) 1.47

Inactivation of Brca2 cooperates with Trp53(R172H) to induce invasive pancreatic ductal adenocarcinomas in mice: a mouse model of familial pancreatic cancer. Cancer Biol Ther (2011) 1.45

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat Struct Mol Biol (2010) 1.44

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A. Breast Cancer Res (2009) 1.44

Replication stress and cancer. Nat Rev Cancer (2015) 1.43

A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo. Nat Methods (2017) 1.40

Intravital microscopy: new insights into metastasis of tumors. J Cell Sci (2011) 1.36

Oxidative stress in Fanconi anemia hematopoiesis and disease progression. Antioxid Redox Signal (2008) 1.33

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet (2009) 1.33

Centrosome amplification causes microcephaly. Nat Cell Biol (2013) 1.33

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization. Genome Res (2004) 1.32

Molecular genetics of supernumerary tooth formation. Genesis (2011) 1.32

Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov (2013) 1.32

Oncogenes and tumor suppressor genes. Cold Spring Harb Perspect Biol (2010) 1.31

Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma. Proc Natl Acad Sci U S A (2014) 1.30

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. J Exp Med (2013) 1.30

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev (2013) 1.30

Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth. Cell Rep (2014) 1.29

A mouse model for the molecular characterization of brca1-associated ovarian carcinoma. Cancer Res (2006) 1.28

Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24

Articles by these authors

Simplified mammalian DNA isolation procedure. Nucleic Acids Res (1991) 12.56

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell (1991) 7.16

Requirement for a functional Rb-1 gene in murine development. Nature (1992) 6.87

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev (1994) 6.10

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev (2000) 5.71

Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell (1984) 5.56

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell (1995) 5.54

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev (1999) 5.35

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc Natl Acad Sci U S A (2001) 4.51

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc Natl Acad Sci U S A (1992) 4.50

Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res (1997) 3.70

A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep (2001) 3.67

Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells. Nature (1990) 3.57

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature (2001) 3.57

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell (1994) 3.57

Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J Exp Med (1997) 3.53

Structure of Moloney murine leukemia viral DNA: nucleotide sequence of the 5' long terminal repeat and adjacent cellular sequences. Proc Natl Acad Sci U S A (1980) 3.53

In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. Cell (1988) 3.34

Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell (1989) 3.31

Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation. EMBO J (1984) 3.28

Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. Genes Dev (1997) 2.96

Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element. EMBO J (1988) 2.93

Clinical presentation, endoscopic features, and treatment of gastric metastases from breast carcinoma. Cancer (2000) 2.82

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci U S A (1999) 2.76

Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev (2000) 2.72

M-MuLV-induced leukemogenesis: integration and structure of recombinant proviruses in tumors. Cell (1981) 2.65

Retroviral insertional mutagenesis: past, present and future. Oncogene (2005) 2.63

Characterization of AKR murine leukemia virus sequences in AKR mouse substrains and structure of integrated recombinant genomes in tumor tissues. J Virol (1981) 2.62

The spectrum of gastrointestinal metastases of breast carcinoma: II. The colon and rectum. Gastrointest Endosc (1992) 2.56

p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev (1998) 2.53

Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice. Nat Genet (1996) 2.47

Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas. EMBO J (1985) 2.47

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. EMBO J (1994) 2.44

Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature (1991) 2.33

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci U S A (1998) 2.29

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. EMBO J (1991) 2.26

Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene. Oncogene (2001) 2.21

Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development (2001) 2.21

Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim Biophys Acta (1996) 2.13

The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech Dev (1996) 2.13

Monoclonal antibodies against human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors. Int J Cancer (1984) 2.12

Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally. Mol Cell Biol (1991) 2.06

The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases. Cell (1986) 2.06

Regeneration of herpesviruses from molecularly cloned subgenomic fragments. J Virol (1988) 2.06

T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous alpha- and beta-genes. Nature (1988) 2.06

Identification and molecular cloning of Moloney mouse sarcoma virus-specific sequences from uninfected mouse cells. Proc Natl Acad Sci U S A (1980) 1.98

Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger. Oncogene (1997) 1.98

The integration sites of endogenous and exogenous Moloney murine leukemia virus. Cell (1979) 1.87

Presence of markers for virulence in the unique short region or repeat region or both of pseudorabies hybrid viruses. J Virol (1985) 1.85

Risk factors in breast-conservation therapy. J Clin Oncol (1994) 1.82

Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature (1995) 1.80

Increase of AKR-specific sequences in tumor tissues of leukemic AKR mice. Proc Natl Acad Sci U S A (1976) 1.79

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med (1997) 1.75

Tumorigenesis by slow-transforming retroviruses--an update. Biochim Biophys Acta (1990) 1.71

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse. Oncogene (1998) 1.71

Molecular cloning of unintegrated Moloney mouse sarcoma virus DNA in bacteriophage lambda. Proc Natl Acad Sci U S A (1980) 1.68

Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice. J Virol (1997) 1.66

Live attenuated pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus protects swine against both pseudorabies and hog cholera. J Virol (1991) 1.60

Immunological defects in mice with a targeted disruption in Bcl-3. Genes Dev (1997) 1.60

Generation of AKR mink cell focus-forming viruses: a conserved single-copy xenotrope-like provirus provides recombinant long terminal repeat sequences. J Virol (1984) 1.59

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. Nat Genet (1999) 1.59

Haplo-insufficiency? Let me count the ways. Genes Dev (2001) 1.59

Identification of two genes in the unique short region of pseudorabies virus; comparison with herpes simplex virus and varicella-zoster virus. J Gen Virol (1990) 1.57

The spectrum of gastrointestinal metastases of breast carcinoma: I. Stomach. Gastrointest Endosc (1992) 1.57

Mice with a targeted disruption of the Fanconi anemia homolog Fanca. Hum Mol Genet (2000) 1.56

Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2. EMBO J (1995) 1.55

Mouse models for hereditary nonpolyposis colorectal cancer. Cancer Res (1998) 1.54

Herpesviruses encode an unusual protein-serine/threonine kinase which is nonessential for growth in cultured cells. J Virol (1992) 1.53

Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity. J Exp Med (1990) 1.45

Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc. Oncogene (1997) 1.45

T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells. Proc Natl Acad Sci U S A (1990) 1.43

CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur J Immunol (1994) 1.42

Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. EMBO J (1988) 1.41

In vivo analysis of Pim-1 deficiency. Nucleic Acids Res (1993) 1.40

Developmental defects and tumor predisposition in Rb mutant mice. Oncogene (1999) 1.37

Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein. Genes Dev (1999) 1.37

Complementation tagging of cooperating oncogenes in knockout mice. Semin Cancer Biol (1996) 1.37

E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice. Oncogene (1991) 1.37

Construction and characterization of deletion mutants of pseudorabies virus: a new generation of 'live' vaccines. J Gen Virol (1987) 1.36

Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas. EMBO J (1989) 1.35

N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas. EMBO J (1989) 1.33

Thymic lymphomas in interleukin 9 transgenic mice. Oncogene (1994) 1.33

Self-tolerance to transgenic gamma delta T cells by intrathymic inactivation. Nature (1990) 1.32

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest (2000) 1.32

Characterization and chromosomal localization of the human proto-oncogene BMI-1. Hum Mol Genet (1993) 1.28

Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. Nat Genet (1995) 1.27

Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice. Nature (1989) 1.25