Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 4536076)

Published in PLoS One on August 13, 2015

Authors

Maria Zeniou1, Marie Fève1, Samir Mameri1, Jihu Dong1, Christophe Salomé1, Wanyin Chen1, Elias A El-Habr2, Fanny Bousson1, Mohamadou Sy1, Julie Obszynski1, Alexandre Boh1, Pascal Villa3, Suzana Assad Kahn2, Bruno Didier4, Dominique Bagnard5, Marie-Pierre Junier2, Hervé Chneiweiss2, Jacques Haiech1, Marcel Hibert1, Marie-Claude Kilhoffer1

Author Affiliations

1: Laboratoire d'Innovation Thérapeutique, Université de Strasbourg / CNRS UMR7200, Laboratoire d'Excellence Medalis, Faculté de Pharmacie, 74 route du Rhin, 67401 Illkirch, France.
2: Neuroscience Paris Seine-IBPS, CNRS UMR 8246/ Inserm U1130/ UPMC UMCR18, 7 quai Saint Bernard, 75005 Paris, France.
3: Plateforme de Chimie Biologie Intégrative (PCBIS), Université de Strasbourg / CNRS UMS 3286, Laboratoire d'Excellence Medalis, ESBS Pôle API-Bld Sébastien Brant, 67401 Illkirch, France.
4: Laboratoire d'Innovation Thérapeutique, Université de Strasbourg / CNRS UMR7200, Laboratoire d'Excellence Medalis, Faculté de Pharmacie, 74 route du Rhin, 67401 Illkirch, France; Plateforme de Chimie Biologie Intégrative (PCBIS), Université de Strasbourg / CNRS UMS 3286, Laboratoire d'Excellence Medalis, ESBS Pôle API-Bld Sébastien Brant, 67401 Illkirch, France.
5: U682, Inserm, Université de Strasbourg, 3, Avenue Molière, 67200 Strasbourg, France.

Articles cited by this

(truncated to the top 100)

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med (2005) 74.55

Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J Biomol Screen (1999) 32.67

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63

Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev (2007) 17.20

Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell (2009) 12.96

A restricted cell population propagates glioblastoma growth after chemotherapy. Nature (2012) 8.88

Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell (2009) 6.77

A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell (2010) 6.47

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science (2014) 6.09

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell (2010) 5.57

Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res (2004) 4.48

CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest (2010) 3.60

Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev (2012) 3.44

Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood (1999) 3.33

The therapeutic promise of the cancer stem cell concept. J Clin Invest (2010) 3.26

Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML). Blood (2002) 2.44

The antitumor activities of flavonoids. In Vivo (2005) 2.34

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One (2009) 2.20

Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat Rev Cancer (2014) 2.09

Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem (2009) 2.07

Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets (2008) 1.95

CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells. Oncogene (2010) 1.82

Overexpression of Eag1 potassium channels in clinical tumours. Mol Cancer (2006) 1.78

Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma. Clin Exp Metastasis (2009) 1.71

Quiescent, slow-cycling stem cell populations in cancer: a review of the evidence and discussion of significance. J Oncol (2010) 1.63

Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med (2008) 1.53

Selective serotonin reuptake inhibitors, glioblastoma multiforme, and impact on toxicities and overall survival: the mayo clinic experience. Am J Clin Oncol (2011) 1.45

The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. Cell Death Differ (2011) 1.44

Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines. FEBS Lett (1994) 1.39

High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells. Oncotarget (2012) 1.34

Estrogen receptor-dependent and estrogen receptor-independent pathways for tamoxifen and 4-hydroxytamoxifen-induced programmed cell death. J Biol Chem (2002) 1.32

A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Oncotarget (2013) 1.27

CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors. BMC Cancer (2010) 1.26

Loss of p21 CDKN1A impairs entry to quiescence and activates a DNA damage response in normal fibroblasts induced to quiescence. Cell Cycle (2009) 1.24

IFITM1 plays an essential role in the antiproliferative action of interferon-gamma. Oncogene (2006) 1.24

Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One (2009) 1.18

Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. Cancer Metastasis Rev (2012) 1.18

Eag1 as a cancer target. Expert Opin Ther Targets (2008) 1.17

NFκB inhibitors induce cell death in glioblastomas. Biochem Pharmacol (2010) 1.17

Glioblastoma multiforme: Pathogenesis and treatment. Pharmacol Ther (2015) 1.16

A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. Mol Cancer Ther (2011) 1.13

Extending nature's leads: the anticancer agent ellipticine. Curr Med Chem Anticancer Agents (2004) 1.11

Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells. J Neurooncol (2010) 1.11

Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. J Cell Sci (2013) 1.10

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. Arch Biochem Biophys (2014) 1.07

Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects. Arzneimittelforschung (1996) 1.06

Eag and HERG potassium channels as novel therapeutic targets in cancer. World J Surg Oncol (2010) 1.04

Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol Cell Biol (2012) 1.04

Combined effects of GSTP1 and MRP1 in melanoma drug resistance. Br J Cancer (2005) 1.04

Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2. Cancer Res (2010) 1.03

Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors. PLoS One (2011) 1.02

Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action. Mol Nutr Food Res (2013) 1.01

Cardiotoxicity of new antihistamines and cisapride. Toxicol Lett (2002) 0.99

alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int J Cancer (2010) 0.98

An overview of current and emerging SERMs. J Steroid Biochem Mol Biol (2014) 0.98

Augmentation of cisplatin sensitivity in cisplatin-resistant human bladder cancer cells by modulating glutathione concentrations and glutathione-related enzyme activities. BJU Int (2005) 0.98

Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630. PLoS One (2014) 0.98

Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg Med Chem Lett (2012) 0.97

Sensitization of glioma cells to tamoxifen-induced apoptosis by Pl3-kinase inhibitor through the GSK-3β/β-catenin signaling pathway. PLoS One (2011) 0.96

Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfate. Arzneimittelforschung (1975) 0.95

A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis. Eukaryot Cell (2012) 0.94

Pharmacological separation of hEAG and hERG K+ channel function in the human mammary carcinoma cell line MCF-7. Oncol Rep (2008) 0.92

Altered cytosolic Ca2+ dynamics in cultured Guinea pig cardiomyocytes as an in vitro model to identify potential cardiotoxicants. Toxicol In Vitro (2010) 0.92

Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells. J Pharmacol Exp Ther (2010) 0.91

Histamine and histamine receptor antagonists in cancer biology. Inflamm Allergy Drug Targets (2010) 0.91

Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Mol Pharmacol (2010) 0.91

Terfenadine-induced apoptosis in human melanoma cells is mediated through Ca2+ homeostasis modulation and tyrosine kinase activity, independently of H1 histamine receptors. Carcinogenesis (2008) 0.91

Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. Apoptosis (2011) 0.90

Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett (2002) 0.90

Cancer stem cells: a stride towards cancer cure? J Cell Physiol (2010) 0.90

DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling. Int J Cancer (2003) 0.89

Anti-cancer activity of carbamate derivatives of melampomagnolide B. Bioorg Med Chem Lett (2014) 0.88

Luteolin arrests cell cycling, induces apoptosis and inhibits the JAK/STAT3 pathway in human cholangiocarcinoma cells. Asian Pac J Cancer Prev (2014) 0.88

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription. J Biol Chem (2013) 0.88

The stemness phenotype model. ISRN Oncol (2012) 0.88

Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol (2011) 0.87

Targeting Wnt pathway in lymphoma and myeloma cells. Br J Haematol (2008) 0.86

Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res (2012) 0.86

Comparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets. PLoS One (2014) 0.86

Apoptosis of human cholangiocarcinoma cell lines induced by β-escin through mitochondrial caspase-dependent pathway. Phytother Res (2011) 0.86

Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase. Cancer Invest (2008) 0.85

Molecular mechanisms of G0/G1 cell-cycle arrest and apoptosis induced by terfenadine in human cancer cells. Mol Carcinog (2003) 0.85

Tumor inhibitory agent from Magnolia grandiflora (Magnoliaceae). I. Parthenolide. J Pharm Sci (1973) 0.85

The antidepressant sertraline downregulates Akt and has activity against melanoma cells. Pigment Cell Melanoma Res (2008) 0.85

In vitro novel combinations of psychotropics and anti-cancer modalities in U87 human glioblastoma cells. Int J Oncol (2010) 0.85

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells. Blood (2010) 0.85

β-Escin sodium inhibits inducible nitric oxide synthase expression via downregulation of the JAK/STAT pathway in A549 cells. Mol Carcinog (2011) 0.85

Luteolin Induces Apoptosis by Up-regulating miR-34a in Human Gastric Cancer Cells. Technol Cancer Res Treat (2014) 0.85

Involvement of Akt/NF-κB pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo. BMC Cancer (2012) 0.84

Frontiers in targeting glioma stem cells. Eur J Cancer (2010) 0.84

Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells. Neuro Endocrinol Lett (2009) 0.84

Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity. Mol Biol Rep (2013) 0.83

Astemizole: an old anti-histamine as a new promising anti-cancer drug. Anticancer Agents Med Chem (2011) 0.83

Anti-inflammatory and anti-allergic properties of flavonoids. Prog Clin Biol Res (1986) 0.83

Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn J Cancer Res (1995) 0.83

HE4 expression is associated with hormonal elements and mediated by importin-dependent nuclear translocation. Sci Rep (2014) 0.83

Ellipticines as DNA-targeted chemotherapeutics. Curr Med Chem (2014) 0.83

Biochemical and pharmacological differentiation of neuroleptic effect on dopamine D-1 and D-2 receptors. J Neural Transm Suppl (1983) 0.82

Drug screening study using glioma stem-like cells. Mol Med Rep (2012) 0.82