Published in J Clin Immunol on August 18, 2015
Exome and genome sequencing for inborn errors of immunity. J Allergy Clin Immunol (2016) 0.80
STAT3 signaling in immunity. Cytokine Growth Factor Rev (2016) 0.80
Exploring Transcription Factors-microRNAs Co-regulation Networks in Schizophrenia. Schizophr Bull (2015) 0.78
Regulation of Natural Killer Cell Function by STAT3. Front Immunol (2016) 0.76
The role of IL-6 in host defence against infections: immunobiology and clinical implications. Nat Rev Rheumatol (2017) 0.75
Lung Disease in Primary Antibody Deficiencies. J Allergy Clin Immunol Pract (2016) 0.75
Up, Down, and All Around: Diagnosis and Treatment of Novel STAT3 Variant. Front Pediatr (2017) 0.75
Autoimmunity/inflammation in a monogenic primary immunodeficiency cohort. Clin Transl Immunology (2017) 0.75
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
UniProt: a hub for protein information. Nucleic Acids Res (2014) 16.72
Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol (2002) 15.33
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science (1994) 11.33
STAT3 mutations in the hyper-IgE syndrome. N Engl J Med (2007) 8.99
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature (2008) 8.17
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity (1999) 7.90
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A (1997) 7.08
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature (2007) 7.07
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (2009) 6.14
Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder. N Engl J Med (1999) 5.82
Function of mitochondrial Stat3 in cellular respiration. Science (2009) 5.13
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N Engl J Med (2012) 4.85
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med (2008) 4.76
Tofacitinib versus methotrexate in rheumatoid arthritis. N Engl J Med (2014) 4.64
Serine phosphorylation of STATs. Oncogene (2000) 4.21
Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med (2012) 4.15
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency. Nat Genet (2003) 3.95
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med (2013) 3.92
Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J Exp Med (2008) 3.85
IL-6: regulator of Treg/Th17 balance. Eur J Immunol (2010) 3.82
Extreme hyperimmunoglobulinemia E and undue susceptibility to infection. Pediatrics (1972) 3.75
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med (2011) 3.63
Growth hormone insensitivity associated with a STAT5b mutation. N Engl J Med (2003) 3.31
Job's Syndrome. Recurrent, "cold", staphylococcal abscesses. Lancet (1966) 3.27
STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med (2011) 3.11
JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med (2013) 3.07
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity (2011) 2.77
Genetic linkage of hyper-IgE syndrome to chromosome 4. Am J Hum Genet (1999) 2.63
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood (2012) 2.55
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature (2015) 2.52
Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Science (2001) 2.52
Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. J Allergy Clin Immunol (2008) 2.50
Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet (2010) 2.44
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med (2010) 2.42
Roles of unphosphorylated STATs in signaling. Cell Res (2008) 2.27
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood (2014) 2.17
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory. Immunity (2011) 2.15
Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas. J Exp Med (2011) 2.03
Inborn errors of human JAKs and STATs. Immunity (2012) 1.90
Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency. J Immunol (2006) 1.79
Activating STAT6 mutations in follicular lymphoma. Blood (2014) 1.63
Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nat Genet (2014) 1.62
Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood (2012) 1.62
The STAT3 isoforms alpha and beta have unique and specific functions. Nat Immunol (2004) 1.62
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood (2005) 1.60
STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients. Blood (2013) 1.59
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood (2014) 1.58
Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome. J Allergy Clin Immunol (2013) 1.49
Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome. J Allergy Clin Immunol (2009) 1.49
Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome. J Allergy Clin Immunol (2010) 1.36
Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey. Medicine (Baltimore) (2012) 1.31
Hyper-IgE syndrome update. Ann N Y Acad Sci (2012) 1.31
Bone marrow transplantation does not correct the hyper IgE syndrome. Bone Marrow Transplant (2000) 1.30
Mechanisms of Jak/STAT signaling in immunity and disease. J Immunol (2015) 1.27
SOCS3, a Major Regulator of Infection and Inflammation. Front Immunol (2014) 1.24
An update on the hyper-IgE syndromes. Arthritis Res Ther (2012) 1.23
STAT3 the oncogene - still eluding therapy? FEBS J (2015) 1.20
Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. J Allergy Clin Immunol (2013) 1.19
Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3. Blood (2014) 1.18
IL-6, IL-17 and STAT3: a holy trinity in auto-immunity? Front Biosci (Landmark Ed) (2012) 1.18
Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity. J Clin Invest (2015) 1.14
The clinical spectrum of patients with deficiency of Signal Transducer and Activator of Transcription-1. Pediatr Infect Dis J (2011) 1.11
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. Leukemia (2013) 1.10
Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells. J Exp Med (2013) 1.07
Insights into the role of STAT3 in human lymphocyte differentiation as revealed by the hyper-IgE syndrome. J Immunol (2009) 1.06
Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells. J Exp Med (2011) 1.06
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases. Curr Opin Pediatr (2013) 1.06
Novel and recurrent STAT3 mutations in hyper-IgE syndrome patients from different ethnic groups. Mol Immunol (2008) 1.05
Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis. J Allergy Clin Immunol (2010) 1.03
Autoimmune lymphoproliferative syndrome. Curr Opin Allergy Clin Immunol (2004) 1.02
Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function. J Allergy Clin Immunol (2013) 1.01
STAT2 deficiency and susceptibility to viral illness in humans. Proc Natl Acad Sci U S A (2013) 1.01
Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations. J Rheumatol (2012) 1.00
Of alphas and betas: distinct and overlapping functions of STAT3 isoforms. Front Biosci (2008) 0.99
Successful long-term immunologic reconstitution by allogeneic hematopoietic stem cell transplantation cures patients with autosomal dominant hyper-IgE syndrome. J Allergy Clin Immunol (2010) 0.98
Effects of allogeneic peripheral stem cell transplantation in a patient with job syndrome of hyperimmunoglobulinemia E and recurrent infections. Am J Med (1998) 0.97
STAT3 is a central regulator of lymphocyte differentiation and function. Curr Opin Immunol (2014) 0.94
STAT3 and the Hyper-IgE syndrome: Clinical presentation, genetic origin, pathogenesis, novel findings and remaining uncertainties. JAKSTAT (2013) 0.94
Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes. Biochem J (2012) 0.94
Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism. J Allergy Clin Immunol (2013) 0.92
Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils. J Leukoc Biol (1998) 0.92
TH17 deficiency in human disease. J Allergy Clin Immunol (2012) 0.92
Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. Blood (2002) 0.90
Frequent and widespread vascular abnormalities in human signal transducer and activator of transcription 3 deficiency. Circ Cardiovasc Genet (2011) 0.87
Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations. Ann Med (2014) 0.87
STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway. J Biosci (2012) 0.87
Identification and characterization of cis elements in the STAT3 gene regulating STAT3 alpha and STAT3 beta messenger RNA splicing. Blood (2001) 0.86
STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function. J Exp Med (2015) 0.86
Diffuse large B-cell lymphoma in hyperimmunoglobulinemia E syndrome. Clin Lymphoma Myeloma (2007) 0.85
An adolescent with marked hyperimmuno-globulinemia E showing minimal change nephrotic syndrome and a STAT3 gene mutation. Clin Nephrol (2011) 0.81
Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance. Blood (2014) 0.81
Successful haploidentical donor hematopoietic stem cell transplant and restoration of STAT3 function in an adolescent with autosomal dominant hyper-IgE syndrome. J Clin Immunol (2015) 0.80
SH2-domain mutations in STAT3 in hyper-IgE syndrome patients result in impairment of IL-10 function. Eur J Immunol (2011) 0.80
Hyper-IgE syndrome with a novel STAT3 mutation-a single center study from India. Asian Pac J Allergy Immunol (2014) 0.79
Tocilizumab: a review of its use in the treatment of juvenile idiopathic arthritis. Paediatr Drugs (2013) 0.79
Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation. J Allergy Clin Immunol (2011) 0.79
Identification of a novel STAT3 mutation in a patient with hyper-IgE syndrome. Scand J Infect Dis (2012) 0.79
Novel STAT3 mutation causing hyper-IgE syndrome: studies of the clinical course and immunopathology. J Clin Immunol (2014) 0.79