A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.

PubWeight™: 2.15‹?› | Rank: Top 2%

🔗 View Article (PMC 3228524)

Published in Immunity on November 23, 2011

Authors

Andrea M Siegel1, Jennifer Heimall, Alexandra F Freeman, Amy P Hsu, Erica Brittain, Jason M Brenchley, Daniel C Douek, Gary H Fahle, Jeffrey I Cohen, Steven M Holland, Joshua D Milner

Author Affiliations

1: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Articles citing this

Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol (2012) 4.44

JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity (2012) 2.85

Paths to stemness: building the ultimate antitumour T cell. Nat Rev Cancer (2012) 2.79

Human memory T cells: generation, compartmentalization and homeostasis. Nat Rev Immunol (2013) 2.19

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia. Blood (2016) 2.10

Metabolic switching and fuel choice during T-cell differentiation and memory development. Immunol Rev (2012) 2.03

Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Science (2013) 2.00

Essentials of Th17 cell commitment and plasticity. Blood (2013) 1.95

Inborn errors of human JAKs and STATs. Immunity (2012) 1.90

Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes. Curr Opin Immunol (2012) 1.51

The JAK-STAT pathway: impact on human disease and therapeutic intervention. Annu Rev Med (2015) 1.42

An update on the hyper-IgE syndromes. Arthritis Res Ther (2012) 1.23

Antigen availability determines CD8⁺ T cell-dendritic cell interaction kinetics and memory fate decisions. Immunity (2013) 1.09

IL-27 enhances the survival of tumor antigen-specific CD8+ T cells and programs them into IL-10-producing, memory precursor-like effector cells. Eur J Immunol (2013) 1.06

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype. Blood (2016) 1.03

The cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseases. Nat Rev Immunol (2013) 1.02

Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function. J Allergy Clin Immunol (2013) 1.01

Synchronizing transcriptional control of T cell metabolism and function. Nat Rev Immunol (2015) 0.97

Intersection of mTOR and STAT signaling in immunity. Trends Immunol (2014) 0.97

Dual role of miR-21 in CD4+ T-cells: activation-induced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells. PLoS One (2013) 0.97

Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways. Cancer Res (2013) 0.96

Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells. Front Immunol (2014) 0.96

STAT3 and the Hyper-IgE syndrome: Clinical presentation, genetic origin, pathogenesis, novel findings and remaining uncertainties. JAKSTAT (2013) 0.94

Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism. J Allergy Clin Immunol (2013) 0.92

Changing partners at the dance: Variations in STAT concentrations for shaping cytokine function and immune responses to viral infections. JAKSTAT (2013) 0.92

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome. J Exp Med (2015) 0.92

The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia. Haematologica (2014) 0.91

Transcriptional regulation of effector and memory CD8+ T cell fates. Curr Opin Immunol (2013) 0.91

Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species. J Allergy Clin Immunol (2012) 0.90

B-lymphocyte lineage cells and the respiratory system. J Allergy Clin Immunol (2013) 0.89

Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. Circulation (2012) 0.88

Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells. J Immunol (2013) 0.88

Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes. J Virol (2013) 0.87

STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation. Proc Natl Acad Sci U S A (2014) 0.87

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function. J Exp Med (2015) 0.86

Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection. Curr Immunol Rev (2013) 0.85

DNA methylation changes separate allergic patients from healthy controls and may reflect altered CD4+ T-cell population structure. PLoS Genet (2014) 0.85

Determinants of the extent and duration of STAT3 signaling. JAKSTAT (2012) 0.85

Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation. Blood (2014) 0.85

IL-21 Signaling in Immunity. F1000Res (2016) 0.84

The Yin and Yang aspects of IL-27 in induction of cancer-specific T-cell responses and immunotherapy. Immunotherapy (2015) 0.83

T cell vaccinology: exploring the known unknowns. Vaccine (2012) 0.83

Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity. PLoS One (2013) 0.83

Transforming growth factor-β signaling is constantly shaping memory T-cell population. Proc Natl Acad Sci U S A (2015) 0.82

The smallest unit: effector and memory CD8(+) T cell differentiation on the single cell level. Front Immunol (2013) 0.82

The immunological synapse: the gateway to the HIV reservoir. Immunol Rev (2013) 0.82

Genomic and computational approaches to dissect the mechanisms of STAT3's universal and cell type-specific functions. JAKSTAT (2013) 0.82

The Ying and Yang of STAT3 in Human Disease. J Clin Immunol (2015) 0.82

B lymphocytes from patients with a hypomorphic mutation in STAT3 resist Epstein-Barr virus-driven cell proliferation. J Virol (2013) 0.82

Keeping STATs on memory CD8+ T cells. Immunity (2011) 0.81

An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells. J Immunol (2015) 0.81

The role of interleukin-21 in HIV infection. Cytokine Growth Factor Rev (2012) 0.81

Successful haploidentical donor hematopoietic stem cell transplant and restoration of STAT3 function in an adolescent with autosomal dominant hyper-IgE syndrome. J Clin Immunol (2015) 0.80

Memory CD8 T cell transcriptional plasticity. F1000Prime Rep (2015) 0.80

The role of IL-27 in the induction of anti-tumor cytotoxic T lymphocyte response. Am J Transl Res (2013) 0.80

STAT3 signaling in immunity. Cytokine Growth Factor Rev (2016) 0.80

Multi-layered epigenetic mechanisms contribute to transcriptional memory in T lymphocytes. BMC Immunol (2015) 0.79

Novel STAT3 mutation causing hyper-IgE syndrome: studies of the clinical course and immunopathology. J Clin Immunol (2014) 0.79

The Hyper-IgE Syndromes: Lessons in Nature, From Bench to Bedside. World Allergy Organ J (2012) 0.79

IL-27 receptor signaling regulates memory CD4+ T cell populations and suppresses rapid inflammatory responses during secondary malaria infection. Infect Immun (2013) 0.79

Orf Infection in a Patient with Stat1 Gain-of-Function. J Clin Immunol (2014) 0.79

Vaccinia virus induces rapid necrosis in keratinocytes by a STAT3-dependent mechanism. PLoS One (2014) 0.79

Eosinophilia Associated with Disorders of Immune Deficiency or Immune Dysregulation. Immunol Allergy Clin North Am (2015) 0.78

Viral microRNAs Target a Gene Network, Inhibit STAT Activation, and Suppress Interferon Responses. Sci Rep (2017) 0.77

C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. Open Biol (2016) 0.77

Disparate roles for STAT5 in primary and secondary CTL responses. J Immunol (2013) 0.77

Early in vivo signaling profiles in MUC1-specific CD4(+) T cells responding to two different MUC1-targeting vaccines in two different microenvironments. Oncoimmunology (2013) 0.77

Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases. Proc Natl Acad Sci U S A (2013) 0.76

T-cell STAT3 is required for the maintenance of humoral immunity to LCMV. Eur J Immunol (2014) 0.76

Cancers Related to Immunodeficiencies: Update and Perspectives. Front Immunol (2016) 0.75

Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via Nsp5 by Inducing STAT3 Degradation. J Virol (2016) 0.75

Patients informing immunobiology: How disorders of IL-21 receptor signaling unravel pathways of CD8 T-cell function. J Allergy Clin Immunol (2013) 0.75

Primary immunodeficiency update: Part I. Syndromes associated with eczematous dermatitis. J Am Acad Dermatol (2015) 0.75

A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases. Front Microbiol (2016) 0.75

Ablation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency In Vivo. MBio (2016) 0.75

Mitochondrial Stat3, the Need for Design Thinking. Int J Biol Sci (2016) 0.75

Hemoptysis in a Patient with Elevated Immunoglobulin E. J Allergy Clin Immunol Pract (2016) 0.75

Signal transducer and activator of transcription 3: a year in review. Curr Opin Hematol (2016) 0.75

Hyper-IgE Syndromes and the Lung. Clin Chest Med (2016) 0.75

Regulation of NKG2D(+)CD8(+) T-cell-mediated antitumor immune surveillance: Identification of a novel CD28 activation-mediated, STAT3 phosphorylation-dependent mechanism. Oncoimmunology (2016) 0.75

Differential role of gp130-dependent STAT and Ras signalling for haematopoiesis following bone-marrow transplantation. PLoS One (2012) 0.75

PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients. J Exp Med (2017) 0.75

Recurrent and Sustained Viral Infections in Primary Immunodeficiencies. Front Immunol (2017) 0.75

Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities. Cancer Immunol Immunother (2017) 0.75

Articles cited by this

Stat3 as an oncogene. Cell (1999) 17.39

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol (2003) 15.51

STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem (2007) 10.41

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity (2008) 9.61

STAT3 mutations in the hyper-IgE syndrome. N Engl J Med (2007) 8.99

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med (1994) 8.97

Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature (2008) 8.17

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature (2007) 7.07

A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity (2008) 6.41

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science (1995) 6.28

Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science (2000) 6.22

Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science (2011) 6.19

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med (2009) 5.55

Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med (2009) 5.27

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. Proc Natl Acad Sci U S A (2005) 5.21

A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med (2009) 5.20

A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction. Mayo Clin Proc (2007) 5.13

What does Stat3 do? J Clin Invest (2002) 4.83

IL-21 is required to control chronic viral infection. Science (2009) 4.80

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med (2008) 4.76

A vital role for interleukin-21 in the control of a chronic viral infection. Science (2009) 4.55

Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity (2009) 4.42

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J Clin Invest (2001) 4.37

Postherpetic neuralgia--pathogenesis, treatment, and prevention. N Engl J Med (1996) 4.36

Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet (2000) 4.17

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science (2009) 3.90

The incidence of herpes zoster. Arch Intern Med (1995) 3.87

Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J Exp Med (2008) 3.85

A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity (2009) 3.66

Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity (2009) 3.66

IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell (2011) 3.61

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 3.52

Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J Exp Med (2002) 3.43

Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science (1995) 3.43

From vaccines to memory and back. Immunity (2010) 3.30

X-linked agammaglobulinemia: report on a United States registry of 201 patients. Medicine (Baltimore) (2006) 2.66

Genetic linkage of hyper-IgE syndrome to chromosome 4. Am J Hum Genet (1999) 2.63

Immune responses to varicella-zoster in the aged. Arch Intern Med (1982) 2.59

Postherpetic neuralgia. J R Coll Gen Pract (1975) 2.57

Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. J Allergy Clin Immunol (2008) 2.50

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med (2010) 2.42

Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells. Nat Immunol (2002) 2.20

Generation of effector CD8+ T cells and their conversion to memory T cells. Immunol Rev (2010) 1.85

Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. J Immunol (2004) 1.81

Reactivation of latent Epstein-Barr virus by methotrexate: a potential contributor to methotrexate-associated lymphomas. J Natl Cancer Inst (2004) 1.80

Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood (2008) 1.68

Initial antigen encounter programs CD8+ T cells competent to develop into memory cells that are activated in an antigen-free, IL-7- and IL-15-rich environment. J Immunol (2004) 1.54

IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection. J Immunol (2006) 1.43

Clinical manifestations of hyper IgE syndromes. Dis Markers (2010) 1.37

Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes. Int Immunol (1998) 1.32

The hyperimmunoglobulin E recurrent-infection (Job's) syndrome. A review of the NIH experience and the literature. Medicine (Baltimore) (1983) 1.28

Herpes zoster, immunological deterioration and disease progression in HIV-1 infection. AIDS (1995) 1.20

X-Linked agammaglobulinemia patients are not infected with Epstein-Barr virus: implications for the biology of the virus. J Virol (1999) 1.15

Diffuse large B cell lymphoma in hyper-IgE syndrome due to STAT3 mutation. J Clin Immunol (2010) 1.12

Clinical relevance of cytomegalovirus infection in patients with disorders of the immune system. Clin Microbiol Infect (2007) 1.12

The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor. Blood (2009) 1.11

Reduced memory B cells in patients with hyper IgE syndrome. Clin Immunol (2008) 1.03

Recurrent viral infections in patients with past or present atopic dermatitis. Br J Dermatol (1986) 1.02

Hyperimmunoglobulinemia E syndrome associated with coronary artery aneurysms: deficiency of central memory CD4+ T cells and expansion of effector memory CD4+ T cells. Ann Allergy Asthma Immunol (2007) 1.00

Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein 1. J Interferon Cytokine Res (2011) 0.97

Paucity of genotype-phenotype correlations in STAT3 mutation positive Hyper IgE Syndrome (HIES). Clin Immunol (2011) 0.93

Human herpesvirus 6-A, 6-B, and 7 in vitreous fluid samples. J Med Virol (2010) 0.87

Articles by these authors

An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med (2007) 33.18

Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med (2006) 24.38

CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med (2004) 13.55

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature (2005) 13.15

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods (2003) 11.81

HIV preferentially infects HIV-specific CD4+ T cells. Nature (2002) 9.28

STAT3 mutations in the hyper-IgE syndrome. N Engl J Med (2007) 8.99

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med (2009) 8.45

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med (2006) 8.18

Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature (2008) 8.17

A human memory T cell subset with stem cell-like properties. Nat Med (2011) 7.47

Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis (2011) 7.41

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood (2002) 6.73

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest (2003) 6.30

Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis (2009) 6.17

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med (2006) 6.17

Phanerozoic trends in the global diversity of marine invertebrates. Science (2008) 5.36

Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J Exp Med (2007) 5.22

HIV disease: fallout from a mucosal catastrophe? Nat Immunol (2006) 5.08

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med (2009) 4.97

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med (2012) 4.74

Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med (2014) 4.70

Combined immunodeficiency associated with DOCK8 mutations. N Engl J Med (2009) 4.52

Itraconazole to prevent fungal infections in chronic granulomatous disease. N Engl J Med (2003) 4.46

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood (2008) 4.34

Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndrome. Am J Respir Crit Care Med (2008) 4.33

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood (2011) 4.21

Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med (2010) 4.07

T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. J Virol (2004) 4.02

Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo. Nat Immunol (2002) 4.00

The research agenda of the National Institute of Allergy and Infectious Diseases for antimicrobial resistance. J Infect Dis (2008) 3.84

Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. Am J Respir Crit Care Med (2010) 3.83

Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med (2010) 3.81

The characterization of twenty sequenced human genomes. PLoS Genet (2010) 3.72

Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. J Immunol (2007) 3.71

T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity (2004) 3.69

Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J Exp Med (2005) 3.63

PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors. J Clin Invest (2014) 3.54

Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med (2007) 3.45

The molecular basis for public T-cell responses? Nat Rev Immunol (2008) 3.32

Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PLoS Pathog (2010) 3.28

Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation. J Exp Med (2006) 3.26

Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence. J Immunol (2007) 3.24

Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension (2002) 3.23

Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome. Cell (2012) 3.22

CD8+ T cell efficacy in vaccination and disease. Nat Med (2008) 3.20

Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. Eur J Immunol (2007) 3.18

Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol (2009) 3.13

A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape. J Immunol (2002) 3.07

JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med (2013) 3.07

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Nat Med (2005) 3.01

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia. Blood (2009) 3.00

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proc Natl Acad Sci U S A (2014) 2.95

SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood (2007) 2.95

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation. Blood (2009) 2.92

Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies. Lancet (2004) 2.90

Adult-onset immunodeficiency in Thailand and Taiwan. N Engl J Med (2012) 2.87

Collagen deposition limits immune reconstitution in the gut. J Infect Dis (2008) 2.85

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85

Microbial translocation in HIV infection: causes, consequences and treatment opportunities. Nat Rev Microbiol (2012) 2.84

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood (2013) 2.82

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. Nature (2011) 2.82

Gastrointestinal involvement in chronic granulomatous disease. Pediatrics (2004) 2.80

Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome. Blood (2010) 2.77

HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome. Sci Transl Med (2012) 2.72

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia. Blood (2006) 2.69

Residual NADPH oxidase and survival in chronic granulomatous disease. N Engl J Med (2010) 2.61

Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge. J Exp Med (2006) 2.60

Cohort study of molecular identification and typing of Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium bolletii. J Clin Microbiol (2009) 2.58

Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria. Clin Infect Dis (2008) 2.55

CD4 T follicular helper cell dynamics during SIV infection. J Clin Invest (2012) 2.55

Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein. Proc Natl Acad Sci U S A (2004) 2.51