Updated Mechanisms of Sickle Cell Disease-Associated Chronic pain.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 26301256)

Published in Transl Perioper Pain Med on July 26, 2015

Authors

Brianna Lutz1, Steffen E Meiler2, Alex Bekker1, Yuan-Xiang Tao3

Author Affiliations

1: Department of Anesthesiology, Rutgers Graduate School of Biomedical Sciences, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA.
2: Department of Anesthesiology and Perioperative Medicine, Georgia Regents University, Augusta, GA, USA.
3: Department of Anesthesiology, Rutgers Graduate School of Biomedical Sciences, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA ; Departments of Cell Biology & Molecular Medicine, Pharmacology & Physiology, and Neurology & Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA.

Articles cited by this

Pain in sickle cell disease. Rates and risk factors. N Engl J Med (1991) 9.75

Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain (2009) 7.11

Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. JAMA (2014) 5.01

Population estimates of sickle cell disease in the U.S. Am J Prev Med (2010) 4.64

Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease. Science (1997) 4.25

Pathogenesis and treatment of sickle cell disease. N Engl J Med (1997) 4.04

Daily assessment of pain in adults with sickle cell disease. Ann Intern Med (2008) 3.81

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med (2000) 3.71

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov (2007) 3.39

Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review. Am J Epidemiol (2000) 3.17

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids. Blood (2010) 2.45

Knockout-transgenic mouse model of sickle cell disease. Science (1997) 2.38

Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease. Blood (2005) 2.37

Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion. Blood (2000) 2.10

Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin J Pain (2008) 2.06

Transgenic sickle mice have vascular inflammation. Blood (2003) 2.03

Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood (2013) 1.94

Hospital readmission for adult acute sickle cell painful episodes: frequency, etiology, and prognostic significance. Am J Hematol (2005) 1.77

Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatin. Blood (2004) 1.73

Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J Exp Med (1990) 1.60

Human sickle hemoglobin in transgenic mice. Science (1990) 1.54

Plasma endothelin-1, cytokine, and prostaglandin E2 levels in sickle cell disease and acute vaso-occlusive sickle crisis. Blood (1998) 1.54

The natural history of sickle cell disease. Cold Spring Harb Perspect Med (2013) 1.49

ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. II. Modulation of neuronal excitability. J Neurophysiol (2003) 1.49

Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. Blood (2011) 1.42

Patients with sickle cell disease have increased sensitivity to cold and heat. Am J Hematol (2012) 1.38

Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease. Br J Haematol (2006) 1.34

Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats. J Neurosci (2001) 1.30

Expression and localization of endothelin receptors: implications for the involvement of peripheral glia in nociception. J Neurosci (2001) 1.28

Endothelin receptors and pain. J Pain (2009) 1.27

Current issues in sickle cell pain and its management. Hematology Am Soc Hematol Educ Program (2007) 1.22

Serum levels of substance P are elevated in patients with sickle cell disease and increase further during vaso-occlusive crisis. Blood (1998) 1.20

Modulation of endothelial cell activation in sickle cell disease: a pilot study. Blood (2001) 1.17

Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness. Br J Haematol (2011) 1.09

Hydroxyurea and acute painful crises in sickle cell anemia: effects on hospital length of stay and opioid utilization during hospitalization, outpatient acute care contacts, and at home. J Pain Symptom Manage (2010) 1.09

Endothelin-1 enhances capsaicin-evoked intracellular Ca2+ response via activation of endothelin a receptor in a protein kinase Cepsilon-dependent manner in dorsal root ganglion neurons. Neuroscience (2005) 1.09

Management of sickle cell disease from childhood through adulthood. Blood Rev (2013) 1.09

Endothelin-1-induced pain and hyperalgesia: a review of pathophysiology, clinical manifestations and future therapeutic options. Neuropeptides (2008) 1.07

Endothelin-1 (ET-1) selectively enhances the activation gating of slowly inactivating tetrodotoxin-resistant sodium currents in rat sensory neurons: a mechanism for the pain-inducing actions of ET-1. J Neurosci (2002) 1.02

Sensitization of primary afferent nociceptors induced by intradermal capsaicin involves the peripheral release of calcitonin gene-related Peptide driven by dorsal root reflexes. J Pain (2008) 1.02

Association between wind speed and the occurrence of sickle cell acute painful episodes: results of a case-crossover study. Br J Haematol (2008) 1.00

Endothelin-1 potentiates capsaicin-induced TRPV1 currents via the endothelin A receptor. Exp Biol Med (Maywood) (2006) 0.99

Endothelin 1 activates and sensitizes human C-nociceptors. Pain (2007) 0.99

Cold hypersensitivity increases with age in mice with sickle cell disease. Pain (2014) 0.98

Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease. Pain (2015) 0.98

Endothelin as a clinical target in the treatment of systemic hypertension. Cardiol Rev (2009) 0.98

Mechanism-driven phase I translational study of trifluoperazine in adults with sickle cell disease. Eur J Pharmacol (2013) 0.98

Neurosensory changes in a human model of endothelin-1 induced pain: a behavioral study. Neurosci Lett (2007) 0.97

Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia. Clin Hemorheol Microcirc (2011) 0.97

Exercise-related complications in sickle cell trait. Clin Hemorheol Microcirc (2013) 0.96

Endothelin-1 expression in vascular adventitial fibroblasts. Am J Physiol Heart Circ Physiol (2005) 0.96

Tactile allodynia initiated by local subcutaneous endothelin-1 is prolonged by activation of TRPV-1 receptors. Exp Biol Med (Maywood) (2006) 0.96

Sickle cell disease: time for a closer look at treatment options? Br J Haematol (2013) 0.95

Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors. Mol Pain (2012) 0.94

Neurobiological mechanisms of pain in sickle cell disease. Hematology Am Soc Hematol Educ Program (2010) 0.89

Side effects of hydroxyurea in patients with Thalassemia major and thalassemia intermedia and sickle cell anemia. Iran J Ped Hematol Oncol (2014) 0.88

Pediatric vasoocclusive crisis and weather conditions. J Emerg Med (2010) 0.88

Nociceptive sensitization by endothelin-1. Brain Res Rev (2008) 0.86

Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats. Neurosci Lett (2009) 0.86

Management of vasoocclusive pain events in sickle cell disease. Pediatr Emerg Care (2007) 0.85

Peripheral substance P and neurokinin-1 receptors have a role in inflammatory and neuropathic orofacial pain models. Neuropeptides (2012) 0.84

New perspectives on the endothelin axis in pain. Pharmacol Res (2011) 0.84

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies. Hematology Am Soc Hematol Educ Program (2013) 0.83

Morphine stimulates platelet-derived growth factor receptor-β signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo. Br J Anaesth (2013) 0.83

Pain control in sickle cell disease patients: use of complementary and alternative medicine. Pain Med (2014) 0.83

Sensory and Thermal Quantitative Testing in Children With Sickle Cell Disease. J Pediatr Hematol Oncol (2015) 0.83

Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation. Br J Haematol (2013) 0.82

Sickle cell disease in mice is associated with sensitization of sensory nerve fibers. Exp Biol Med (Maywood) (2014) 0.82

Endothelin receptor-mediated responses in trigeminal ganglion neurons. J Dent Res (2013) 0.81

Benefits of kinesiotherapy and aquatic rehabilitation on sickle cell anemia. A case report. Genet Mol Res (2010) 0.80

ET-1 induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells involves endogenous endothelin-A receptors linked to phospholipase C through Gα(q/11). Pharmacol Res (2011) 0.80

Hypoxia-induced pulmonary endothelin-1 expression is unaltered by nitric oxide. J Appl Physiol (1985) (2002) 0.79

Exercise-Induced Abnormal Increase of Systolic Pulmonary Artery Pressure in Adult Patients With Sickle Cell Anemia: An Exercise Stress Echocardiography Study. Echocardiography (2014) 0.78

Management of the acute painful crisis in sickle cell disease- a re-evaluation of the use of opioids in adult patients. Br J Haematol (2014) 0.78

A retrospective review of acupuncture use for the treatment of pain in sickle cell disease patients: descriptive analysis from a single institution. Clin J Pain (2014) 0.78

Changes in coping, pain, and activity after cognitive-behavioral training: a randomized clinical trial for pediatric sickle cell disease using smartphones. Clin J Pain (2015) 0.78

Not simply misshapen red cells: multimolecular and cellular events in sickle vaso-occlusion. J Clin Invest (2014) 0.77

Novel approaches to the treatment of sickle cell disease: the potential of histone deacetylase inhibitors. Expert Rev Hematol (2012) 0.76