Mutational Analysis of Rab3 Function for Controlling Active Zone Protein Composition at the Drosophila Neuromuscular Junction.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 4552854)

Published in PLoS One on August 28, 2015

Authors

Shirui Chen1, Hannah K Gendelman1, John P Roche1, Peter Alsharif1, Ethan R Graf1

Author Affiliations

1: Department of Biology, Amherst College, Amherst, Massachusetts, United States of America.

Articles cited by this

Short-term synaptic plasticity. Annu Rev Physiol (2002) 16.67

The synaptic vesicle cycle. Annu Rev Neurosci (2004) 12.25

An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci U S A (2007) 12.13

Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release. Science (2006) 5.39

Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. Neuron (2006) 5.16

A conditional tissue-specific transgene expression system using inducible GAL4. Proc Natl Acad Sci U S A (2001) 4.93

Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions. J Comp Physiol A (1994) 4.24

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Nature (1997) 3.63

Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila. Genetics (1996) 3.56

Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev (2013) 3.07

Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. J Neurosci (1997) 3.05

Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release. Neuron (1997) 2.91

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. Cell (1999) 2.76

Assembling the presynaptic active zone: a characterization of an active one precursor vesicle. Neuron (2001) 2.52

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin. Mol Cell Biol (1993) 2.48

Thirty-one flavors of Drosophila rab proteins. Genetics (2007) 2.46

Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction. J Neurosci (2004) 2.43

Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis. Neuron (2002) 2.33

Differential ultrastructure of synaptic terminals on ventral longitudinal abdominal muscles in Drosophila larvae. J Neurobiol (1993) 2.23

Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras. J Biol Chem (1993) 2.23

Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature (2005) 2.23

Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesicles. Neuron (2003) 2.16

Rab3 dynamically controls protein composition at active zones. Neuron (2009) 2.07

Isoprenoid modification of rab proteins terminating in CC or CXC motifs. Proc Natl Acad Sci U S A (1991) 1.99

Structural clues to Rab GTPase functional diversity. J Biol Chem (2005) 1.61

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. Science (2011) 1.59

Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins. J Biol Chem (1997) 1.59

Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. J Neurosci (2006) 1.58

Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. J Biol Chem (2002) 1.56

Visualizing glutamatergic cell bodies and synapses in Drosophila larval and adult CNS. J Comp Neurol (2008) 1.54

Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. J Biol Chem (2003) 1.54

KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD. Nat Cell Biol (2008) 1.49

Preferential localization of glutamate receptors opposite sites of high presynaptic release. Curr Biol (2004) 1.46

Evidence for the involvement of Rab3A in Ca(2+)-dependent exocytosis from adrenal chromaffin cells. J Biol Chem (1994) 1.41

Mutants of Rab3A analogous to oncogenic Ras mutants. Sensitivity to Rab3A-GTPase activating protein and Rab3A-guanine nucleotide releasing factor. J Biol Chem (1993) 1.40

G proteins, effectors and GAPs: structure and mechanism. Curr Opin Struct Biol (1997) 1.39

Optical quantal analysis of synaptic transmission in wild-type and rab3-mutant Drosophila motor axons. Nat Neurosci (2011) 1.34

Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A. J Biol Chem (1992) 1.33

Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states. Nat Commun (2014) 1.28

rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence. Neuron (1991) 1.20

Molecular organization and plasticity of the cytomatrix at the active zone. Curr Opin Neurobiol (2011) 1.19

Structural basis of activation and GTP hydrolysis in Rab proteins. Structure (1999) 1.19

Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3. Proc Natl Acad Sci U S A (2006) 1.18

Rab3-GAP controls the progression of synaptic homeostasis at a late stage of vesicle release. Neuron (2011) 1.18

Structural and functional plasticity of the cytoplasmic active zone. Curr Opin Neurobiol (2010) 1.17

Rab proteins: the key regulators of intracellular vesicle transport. Exp Cell Res (2014) 1.14

Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion. EMBO J (2006) 1.11

Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini. J Biol Chem (2002) 1.08

Dominant negative Rab3D mutants reduce GTP-bound endogenous Rab3D in pancreatic acini. J Biol Chem (2003) 1.02

RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction. J Neurosci (2012) 1.00

Comparison of the effects on secretion in chromaffin and PC12 cells of Rab3 family members and mutants. Evidence that inhibitory effects are independent of direct interaction with Rabphilin3. J Biol Chem (1999) 0.99

The Rab3A GTPase interacts with multiple factors through the same effector domain. Mutational analysis of cross-linking of Rab3A to a putative target protein. J Biol Chem (1993) 0.96

Stathmin is required for stability of the Drosophila neuromuscular junction. J Neurosci (2011) 0.89

Bruchpilot and Synaptotagmin collaborate to drive rapid glutamate release and active zone differentiation. Front Cell Neurosci (2015) 0.86

Fife, a Drosophila Piccolo-RIM homolog, promotes active zone organization and neurotransmitter release. J Neurosci (2012) 0.85

The presynaptic active zone: A dynamic scaffold that regulates synaptic efficacy. Exp Cell Res (2015) 0.80

Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Acta Crystallogr F Struct Biol Commun (2015) 0.76