Published in Front Pharmacol on August 10, 2015
The Role of Oxidative Stress in Myocardial Ischemia and Reperfusion Injury and Remodeling: Revisited. Oxid Med Cell Longev (2016) 0.78
Cardiac excitation-contraction coupling. Nature (2002) 18.48
Oxidative stress and diabetic complications. Circ Res (2010) 9.37
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A (2002) 8.01
Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science (1998) 7.29
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16
Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest (2005) 5.53
Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science (2005) 5.53
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res (2005) 5.34
Endothelial function and oxidative stress in renovascular hypertension. N Engl J Med (2002) 5.30
Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science (1998) 4.58
ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin. Nature (2003) 4.45
The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res (2006) 3.83
Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res (1999) 3.35
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest (2006) 3.33
Cysteine redox sensor in PKGIa enables oxidant-induced activation. Science (2007) 3.29
Calmodulin trapping by calcium-calmodulin-dependent protein kinase. Science (1992) 3.26
Control of cardiac growth by histone acetylation/deacetylation. Circ Res (2006) 3.25
MG53 nucleates assembly of cell membrane repair machinery. Nat Cell Biol (2008) 3.24
PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell (2007) 3.19
Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol (2006) 3.13
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell (2005) 3.08
Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res (2003) 3.04
Bovine complex I is a complex of 45 different subunits. J Biol Chem (2006) 3.01
Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium. Circ Res (1994) 2.82
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A (2006) 2.81
Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res (2005) 2.79
L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices. Circ Res (2002) 2.62
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol (2010) 2.22
Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15. Proc Natl Acad Sci U S A (2003) 2.09
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08
Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation (2002) 1.87
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A (2006) 1.87
Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H₂O₂, and protein chaperones. Antioxid Redox Signal (2011) 1.81
Protein sulfenation as a redox sensor: proteomics studies using a novel biotinylated dimedone analogue. Mol Cell Proteomics (2007) 1.81
Post-infarct remodelling: contribution of wound healing and inflammation. Cardiovasc Res (2008) 1.80
Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes. Proc Natl Acad Sci U S A (2007) 1.79
Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest (2010) 1.77
Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment. Circulation (2003) 1.77
Antioxidant vitamin supplements and cardiovascular disease. Circulation (2004) 1.76
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med (2011) 1.74
Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol. J Biol Chem (2002) 1.73
NO-dependent CaMKII activation during β-adrenergic stimulation of cardiac muscle. Cardiovasc Res (2013) 1.72
Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation. Mol Cell Biol (2010) 1.69
Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res (2011) 1.69
Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. J Biol Chem (2005) 1.64
Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition. J Am Coll Cardiol (2014) 1.64
Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. Annu Rev Cell Biol (1988) 1.63
Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest (2010) 1.60
Contribution of reactive oxygen species to the pathogenesis of left ventricular failure in Dahl salt-sensitive hypertensive rats: effects of angiotensin II blockade. J Hypertens (2006) 1.59
Association of increased phagocytic NADPH oxidase-dependent superoxide production with diminished nitric oxide generation in essential hypertension. J Hypertens (2004) 1.58
Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation. J Biol Chem (2006) 1.58
Phosphorylation of phospholamban and troponin I in beta-adrenergic-induced acceleration of cardiac relaxation. Am J Physiol Heart Circ Physiol (2000) 1.57
Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest (2009) 1.56
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest (2013) 1.53
Cardiac mitochondria and reactive oxygen species generation. Circ Res (2014) 1.51
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48
Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction. Annu Rev Physiol (2013) 1.46
Angiotensin II-induced oxidative stress resets the Ca2+ dependence of Ca2+-calmodulin protein kinase II and promotes a death pathway conserved across different species. Circ Res (2009) 1.45
Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice. Circulation (2004) 1.42
Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy. Hypertension (2014) 1.40
Oxidants in receptor tyrosine kinase signal transduction pathways. Antioxid Redox Signal (2003) 1.38
Cyclic stretch, reactive oxygen species, and vascular remodeling. Antioxid Redox Signal (2009) 1.38
Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. Structure (2010) 1.36
Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation. Circ Res (2009) 1.36
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation (2013) 1.29
Regulation of signal transduction by reactive oxygen species in the cardiovascular system. Circ Res (2015) 1.27
Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. Circ Res (2011) 1.23
Ca2+/calmodulin-dependent protein kinase II: identification of autophosphorylation sites responsible for generation of Ca2+/calmodulin-independence. Proc Natl Acad Sci U S A (1987) 1.23
L-type CaV1.2 calcium channels: from in vitro findings to in vivo function. Physiol Rev (2014) 1.23
Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development. J Biol Chem (2003) 1.23
Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. Nat Med (2012) 1.23
Modulation of recombinant human cardiac L-type Ca2+ channel alpha1C subunits by redox agents and hypoxia. J Physiol (1999) 1.21
Free radicals enhance Na+/Ca2+ exchange in ventricular myocytes. Am J Physiol (1996) 1.18
Redox-mediated reciprocal regulation of SERCA and Na+-Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes. Free Radic Biol Med (2010) 1.17
Na⁺ transport in the normal and failing heart - remember the balance. J Mol Cell Cardiol (2013) 1.14
The chemical biology of S-nitrosothiols. Antioxid Redox Signal (2012) 1.13
Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice. Circ Res (2010) 1.10
Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction. Free Radic Biol Med (2007) 1.10
MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction. J Mol Cell Cardiol (2012) 1.09
Reversible oxidative modification: implications for cardiovascular physiology and pathophysiology. Trends Cardiovasc Med (2010) 1.08
cGMP-dependent activation of protein kinase G precludes disulfide activation: implications for blood pressure control. Hypertension (2012) 1.08
Redox modification of sodium-calcium exchange activity in cardiac sarcolemmal vesicles. J Biol Chem (1986) 1.07
Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na(+) current. Basic Res Cardiol (2010) 1.06
Oxidative stress impairs the function of sarcoplasmic reticulum by oxidation of sulfhydryl groups in the Ca2+-ATPase. Arch Biochem Biophys (1986) 1.04
Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc (2013) 1.04
Glyceraldehyde 3-phosphate dehydrogenase is unlikely to mediate hydrogen peroxide signaling: studies with a novel anti-dimedone sulfenic acid antibody. Antioxid Redox Signal (2010) 1.04
L-type Ca(2+) channel facilitation mediated by H(2)O(2)-induced activation of CaMKII in rat ventricular myocytes. J Mol Cell Cardiol (2009) 1.02
Transnitrosylating nitric oxide species directly activate type I protein kinase A, providing a novel adenylate cyclase-independent cross-talk to beta-adrenergic-like signaling. J Biol Chem (2009) 1.02
Oxidation of multiple methionine residues impairs rapid sodium channel inactivation. Pflugers Arch (2008) 1.00
Redox regulation of sodium and calcium handling. Antioxid Redox Signal (2012) 1.00
Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A (2014) 0.93
Chronic allopurinol administration ameliorates maladaptive alterations in Ca2+ cycling proteins and beta-adrenergic hyporesponsiveness in heart failure. Am J Physiol Heart Circ Physiol (2006) 0.93
The methionine sulfoxide reduction system: selenium utilization and methionine sulfoxide reductase enzymes and their functions. Antioxid Redox Signal (2013) 0.93
Interchain disulfide bonding in the regulatory subunit of cAMP-dependent protein kinase I. J Biol Chem (1982) 0.92
The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. J Biol Chem (2005) 0.90
Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. Eur Heart J (2015) 0.90
A stable alpha-helical domain at the N terminus of the RIalpha subunits of cAMP-dependent protein kinase is a novel dimerization/docking motif. J Biol Chem (1997) 0.89
Nitric oxide induces Ca2+-independent activity of the Ca2+/calmodulin-dependent protein kinase II (CaMKII). J Biol Chem (2014) 0.88
Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. Circ Res (2010) 0.88
Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes. J Mol Cell Cardiol (2014) 0.87