Published in Cell on December 02, 2005
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell (2008) 6.16
Mechanisms of CaMKII action in long-term potentiation. Nat Rev Neurosci (2012) 3.59
Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron (2008) 3.14
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol (2010) 2.22
Structural transitions and thermodynamics of a glycine-dependent riboswitch from Vibrio cholerae. J Mol Biol (2006) 2.19
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J (2008) 2.12
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08
Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B. J Neurosci (2006) 2.05
CaMKII regulation in information processing and storage. Trends Neurosci (2012) 1.96
Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium. Nat Struct Mol Biol (2010) 1.91
Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res (2009) 1.88
Dual mechanism of a natural CaMKII inhibitor. Mol Biol Cell (2007) 1.86
Smooth muscle signalling pathways in health and disease. J Cell Mol Med (2008) 1.72
Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source. J Appl Crystallogr (2013) 1.69
CaMKII in the cardiovascular system: sensing redox states. Physiol Rev (2011) 1.67
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums. Proc Natl Acad Sci U S A (2006) 1.64
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell (2011) 1.56
CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci (2010) 1.49
CaMKIIbeta association with the actin cytoskeleton is regulated by alternative splicing. Mol Biol Cell (2006) 1.39
STDP in a bistable synapse model based on CaMKII and associated signaling pathways. PLoS Comput Biol (2007) 1.35
An electrostatic network and long-range regulation of Src kinases. Protein Sci (2008) 1.30
Analysis of CaM-kinase signaling in cells. Cell Calcium (2011) 1.30
Ca(2+)/calmodulin-dependent protein kinases. Cell Mol Life Sci (2008) 1.30
Structural rearrangement of CaMKIIalpha catalytic domains encodes activation. Proc Natl Acad Sci U S A (2009) 1.29
CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin. J Biol Chem (2010) 1.28
Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. Circ Res (2011) 1.23
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat Struct Mol Biol (2010) 1.21
Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation. Structure (2008) 1.21
Joint use of small-angle X-ray and neutron scattering to study biological macromolecules in solution. Eur Biophys J (2006) 1.20
Nucleotides and phosphorylation bi-directionally modulate Ca2+/calmodulin-dependent protein kinase II (CaMKII) binding to the N-methyl-D-aspartate (NMDA) receptor subunit GluN2B. J Biol Chem (2011) 1.13
Timing in cellular Ca2+ signaling. Curr Biol (2008) 1.10
CaMKII-induced shift in modal gating explains L-type Ca(2+) current facilitation: a modeling study. Biophys J (2009) 1.08
Structural modeling of protein interactions by analogy: application to PSD-95. PLoS Comput Biol (2006) 1.07
Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. J Cell Biol (2012) 1.06
Role of the N- and C-lobes of calmodulin in the activation of Ca(2+)/calmodulin-dependent protein kinase II. Biochemistry (2008) 1.05
Rhizobial and fungal symbioses show different requirements for calmodulin binding to calcium calmodulin-dependent protein kinase in Lotus japonicus. Plant Cell (2012) 1.04
CaMKII in cerebral ischemia. Acta Pharmacol Sin (2011) 1.04
Cytoskeletal signaling: is memory encoded in microtubule lattices by CaMKII phosphorylation? PLoS Comput Biol (2012) 1.03
Autoinhibition and Polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase Haspin to mitosis. Mol Cell (2013) 1.03
{beta}CaMKII regulates actin assembly and structure. J Biol Chem (2009) 1.02
CaMKII oxidative activation and the pathogenesis of cardiac disease. J Mol Cell Cardiol (2014) 1.02
A dynamic model of interactions of Ca2+, calmodulin, and catalytic subunits of Ca2+/calmodulin-dependent protein kinase II. PLoS Comput Biol (2010) 1.00
Mechanisms of CaMKII Activation in the Heart. Front Pharmacol (2014) 0.99
The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS. Nucleic Acids Res (2010) 0.98
Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity. Elife (2013) 0.96
Multi-state modeling of biomolecules. PLoS Comput Biol (2014) 0.96
Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII. PLoS One (2012) 0.95
Food deprivation attenuates seizures through CaMKII and EAG K+ channels. PLoS Genet (2007) 0.95
Signalling pathways underlying structural plasticity of dendritic spines. Br J Pharmacol (2011) 0.95
Variability of distribution of Ca(2+)/calmodulin-dependent kinase II at mixed synapses on the mauthner cell: colocalization and association with connexin 35. J Neurosci (2010) 0.94
The neurobiologist's guide to structural biology: a primer on why macromolecular structure matters and how to evaluate structural data. Neuron (2007) 0.93
Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases. Br J Pharmacol (2008) 0.92
Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation. J Biol Chem (2011) 0.92
An autoinhibited coiled-coil design strategy for split-protein protease sensors. J Am Chem Soc (2009) 0.92
Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling. Int J Parasitol (2011) 0.91
Fluorescence polarization and fluctuation analysis monitors subunit proximity, stoichiometry, and protein complex hydrodynamics. PLoS One (2012) 0.91
Conformational changes underlying calcium/calmodulin-dependent protein kinase II activation. EMBO J (2011) 0.90
Detailed state model of CaMKII activation and autophosphorylation. Eur Biophys J (2008) 0.90
Structure of the nuclear factor κB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation. J Biol Chem (2012) 0.90
Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II. Curr Opin Struct Biol (2013) 0.90
Dissecting cooperative calmodulin binding to CaM kinase II: a detailed stochastic model. J Comput Neurosci (2009) 0.90
Spatiotemporal Regulation of Signaling in and out of Dendritic Spines: CaMKII and Ras. Open Neurosci J (2009) 0.89
A significant but rather mild contribution of T286 autophosphorylation to Ca2+/CaM-stimulated CaMKII activity. PLoS One (2012) 0.89
Calmodulin mediates the Ca2+-dependent regulation of Cx44 gap junctions. Biophys J (2009) 0.87
Energetics of calmodulin domain interactions with the calmodulin binding domain of CaMKII. Proteins (2009) 0.86
Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Proc Natl Acad Sci U S A (2007) 0.86
Evolution of CASK into a Mg2+-sensitive kinase. Sci Signal (2010) 0.85
Target-specific support vector machine scoring in structure-based virtual screening: computational validation, in vitro testing in kinases, and effects on lung cancer cell proliferation. J Chem Inf Model (2011) 0.85
Disrupting the intermolecular self-association of Itk enhances T cell signaling. J Immunol (2010) 0.84
Differential regulation by ATP versus ADP further links CaMKII aggregation to ischemic conditions. FEBS Lett (2009) 0.84
The delicate bistability of CaMKII. Biophys J (2013) 0.84
Improving a natural CaMKII inhibitor by random and rational design. PLoS One (2011) 0.83
Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix. J Biol Chem (2009) 0.83
The effects of transient starvation persist through direct interactions between CaMKII and ether-a-go-go K+ channels in C. elegans males. Neuroscience (2010) 0.82
CaMKII activation and dynamics are independent of the holoenzyme structure: an infinite subunit holoenzyme approximation. Phys Biol (2012) 0.82
Regulation of gastrointestinal motility by Ca2+/calmodulin-stimulated protein kinase II. Arch Biochem Biophys (2011) 0.82
Regulation of CaMKII signaling in cardiovascular disease. Front Pharmacol (2015) 0.82
Calcium/calmodulin-dependent kinase II and Alzheimer's disease. Mol Brain (2015) 0.81
Allosteric activation of apicomplexan calcium-dependent protein kinases. Proc Natl Acad Sci U S A (2015) 0.81
Regulation of Ca2+/calmodulin kinase II by a small C-terminal domain phosphatase. Biochem J (2008) 0.80
Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem (2011) 0.79
Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal. Cardiovasc Res (2016) 0.79
Progress and outlook in structural biology of large viral RNAs. Virus Res (2014) 0.79
Structural analysis and stochastic modelling suggest a mechanism for calmodulin trapping by CaMKII. PLoS One (2012) 0.78
Covert Changes in CaMKII Holoenzyme Structure Identified for Activation and Subsequent Interactions. Biophys J (2015) 0.78
CaMKII structure--an elegant design. Cell (2005) 0.78
CaMKII binding to GluN2B is differentially affected by macromolecular crowding reagents. PLoS One (2014) 0.78
The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer's Disease. Evid Based Complement Alternat Med (2013) 0.77
Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases. Sci Signal (2015) 0.77
Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II. Elife (2016) 0.77
Protection of α-CaMKII from Dephosphorylation by GluN2B Subunit of NMDA Receptor Is Abolished by Mutation of Glu96 or His282 of α-CaMKII. PLoS One (2016) 0.75
Modeling intracellular signaling underlying striatal function in health and disease. Prog Mol Biol Transl Sci (2014) 0.75
Oligomeric interactions provide alternatives to direct steric modes of control of sugar kinase/actin/hsp70 superfamily functions by heterotropic allosteric effectors: inhibition of E. coli glycerol kinase. Arch Biochem Biophys (2009) 0.75
A Memory Molecule, Ca(2+)/Calmodulin-Dependent Protein Kinase II and Redox Stress; Key Factors for Arrhythmias in a Diseased Heart. Korean Circ J (2013) 0.75
Ca(2+) signaling in the myocardium by (redox) regulation of PKA/CaMKII. Front Pharmacol (2015) 0.75
The CaMKII holoenzyme structure in activation-competent conformations. Nat Commun (2017) 0.75
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell (2002) 13.03
The conformational plasticity of protein kinases. Cell (2002) 11.21
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell (2006) 10.28
Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci (2005) 9.17
Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell (2003) 5.44
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell (2009) 4.78
PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med (2004) 4.50
Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature (2004) 4.37
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res (2002) 4.19
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc Natl Acad Sci U S A (2004) 3.87
DARPP-32: an integrator of neurotransmission. Annu Rev Pharmacol Toxicol (2004) 3.84
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. Proc Natl Acad Sci U S A (2006) 3.68
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell (2003) 3.66
A myristoyl/phosphotyrosine switch regulates c-Abl. Cell (2003) 3.48
A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol (2006) 3.40
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains. Nature (2005) 3.24
Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol (2008) 3.18
Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01
Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish. J Neurosci (2006) 2.86
Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature (2007) 2.78
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature (2006) 2.77
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci (2003) 2.70
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell (2007) 2.68
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization. Cell (2012) 2.67
CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol (2008) 2.62
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell (2011) 2.58
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc Natl Acad Sci U S A (2009) 2.55
Conformational coupling across the plasma membrane in activation of the EGF receptor. Cell (2013) 2.49
Structure of a sliding clamp on DNA. Cell (2008) 2.42
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc Natl Acad Sci U S A (2004) 2.41
On the mechanism of MgATP-dependent gating of CFTR Cl- channels. J Gen Physiol (2003) 2.39
Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell (2004) 2.38
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Mol Cell (2011) 2.35
High yield bacterial expression of active c-Abl and c-Src tyrosine kinases. Protein Sci (2005) 2.32
Architecture and membrane interactions of the EGF receptor. Cell (2013) 2.29
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28
PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat Cell Biol (2009) 2.20
A conserved protonation-dependent switch controls drug binding in the Abl kinase. Proc Natl Acad Sci U S A (2008) 2.18
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15
A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature (2008) 2.10
In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer. EMBO J (2006) 2.04
Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating. J Gen Physiol (2003) 2.03
The structure, regulation, and function of ZAP-70. Immunol Rev (2009) 2.01
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res (2006) 1.98
Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. Mol Cell (2003) 1.98
Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III. Cell (2006) 1.94
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit. Proc Natl Acad Sci U S A (2007) 1.93
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature (2002) 1.91
c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure (2007) 1.87
Molecular mechanisms in signal transduction at the membrane. Nat Struct Mol Biol (2010) 1.86
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Proc Natl Acad Sci U S A (2004) 1.84
Clamp loaders and sliding clamps. Curr Opin Struct Biol (2002) 1.77
Motors and switches: AAA+ machines within the replisome. Nat Rev Mol Cell Biol (2002) 1.74
Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal (2013) 1.73
The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell (2009) 1.72
Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol (2006) 1.70
Structural basis for the recognition of c-Src by its inactivator Csk. Cell (2008) 1.66
DARPP-32 mediates the actions of multiple drugs of abuse. AAPS J (2005) 1.66
Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. J Neurosci (2010) 1.64
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations. Cancer Res (2009) 1.64
Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. J Clin Invest (2005) 1.61
Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J Biol Chem (2005) 1.57
A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A (2006) 1.57
The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron (2005) 1.57
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell (2011) 1.56
How a DNA polymerase clamp loader opens a sliding clamp. Science (2011) 1.56
Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Nat Struct Mol Biol (2010) 1.56
Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. J Gen Physiol (2005) 1.55
Synaptic plasticity: one STEP at a time. Trends Neurosci (2006) 1.51
Protein-protein interactions in the allosteric regulation of protein kinases. Curr Opin Struct Biol (2006) 1.49
Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases. J Cell Biol (2005) 1.47
Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics (2015) 1.46
Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A (2010) 1.42
Probing the function of heme distortion in the H-NOX family. ACS Chem Biol (2008) 1.42
Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. FEBS J (2006) 1.40
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol (2006) 1.39
A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci (2003) 1.39
FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity. Nat Neurosci (2008) 1.36
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Cancer Res (2002) 1.34
Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A. J Neurochem (2002) 1.32
Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C. J Biol Chem (2006) 1.32
Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens. Proc Natl Acad Sci U S A (2009) 1.29
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. Proc Natl Acad Sci U S A (2008) 1.28
DNA polymerase clamp loaders and DNA recognition. FEBS Lett (2005) 1.28
Out-of-plane motions in open sliding clamps: molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen. Proc Natl Acad Sci U S A (2005) 1.27
Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Proc Natl Acad Sci U S A (2005) 1.26
Structural basis for protein phosphatase 1 regulation and specificity. FEBS J (2012) 1.26
Regulation of the catalytic activity of the EGF receptor. Curr Opin Struct Biol (2011) 1.26
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. BMC Struct Biol (2008) 1.26
A direct test of the reductionist approach to structural studies of calmodulin activity: relevance of peptide models of target proteins. J Biol Chem (2002) 1.25
Clamp loaders and replication initiation. Curr Opin Struct Biol (2006) 1.25
Analysis of the role of PCNA-DNA contacts during clamp loading. BMC Struct Biol (2010) 1.25
Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle. J Gen Physiol (2006) 1.24