Published in Oncotarget on October 06, 2015
Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas. Proc Natl Acad Sci U S A (2017) 0.84
TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1. Oncogene (2016) 0.78
The C1 domain of Vav3, a novel potential therapeutic target. Cell Signal (2017) 0.75
The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02
Cancer genome landscapes. Science (2013) 25.33
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
Discovery and saturation analysis of cancer genes across 21 tumour types. Nature (2014) 11.68
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Rho GTPases and the control of cell behaviour. Biochem Soc Trans (2005) 5.38
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science (1998) 4.41
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature (1997) 4.05
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J (1989) 3.67
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell (1994) 3.57
Regulatory and signaling properties of the Vav family. Mol Cell Biol (2000) 3.14
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell (2000) 3.08
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature (1992) 3.02
Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature (1992) 2.97
Smart drugs: tyrosine kinase inhibitors in cancer therapy. Cancer Cell (2002) 2.67
Vav-family proteins in T-cell signalling. Curr Opin Immunol (2005) 2.67
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity (2006) 2.57
VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol (2002) 2.57
Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. EMBO J (1998) 2.34
A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity (1997) 2.30
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr Biol (1998) 2.30
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol (1998) 2.26
Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol Cell Biol (1999) 2.19
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity (1996) 2.18
Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med (2003) 2.15
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell (2005) 2.01
The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways. Proc Natl Acad Sci U S A (1999) 1.98
Lck regulates Vav activation of members of the Rho family of GTPases. Mol Cell Biol (1997) 1.96
A functional T-cell receptor signaling pathway is required for p95vav activity. Mol Cell Biol (1995) 1.88
A novel Cdc42Hs mutant induces cellular transformation. Curr Biol (1997) 1.87
Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential. Mol Cell Biol (1991) 1.82
Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity (2002) 1.77
Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells. Science (1992) 1.73
Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav. Mol Cell Biol (2000) 1.71
Mechanism of activation of the vav protooncogene. Cell Growth Differ (1991) 1.71
A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation. Immunity (2000) 1.65
Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation. J Biol Chem (2000) 1.58
Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell (2010) 1.51
Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. J Biol Chem (2000) 1.51
Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion. Cancer Res (2006) 1.49
Structural determinants for the biological activity of Vav proteins. J Biol Chem (2002) 1.49
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol Med (2001) 1.46
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. J Biol Chem (1994) 1.45
Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene (2013) 1.44
Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation. Immunity (2008) 1.43
The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing. J Exp Med (1998) 1.43
Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem (2004) 1.42
Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells. Mol Cell Biol (2001) 1.38
Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Mol Cell Biol (2006) 1.37
Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Mol Cell Biol (1996) 1.34
Structural comparisons of calponin homology domains: implications for actin binding. Structure (1998) 1.30
Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J (2002) 1.28
Does Vav bind to F-actin through a CH domain? FEBS Lett (1995) 1.25
Binding of Vav to Grb2 through dimerization of Src homology 3 domains. Proc Natl Acad Sci U S A (1994) 1.24
Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms. J Exp Med (2001) 1.23
Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion. Carcinogenesis (2007) 1.23
How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42. Oncogene (2001) 1.22
Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. Ann Hum Genet (1995) 1.21
SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. Oncogene (1996) 1.21
Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1. Mol Biol Cell (2005) 1.21
Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. Mol Endocrinol (2006) 1.20
Guanine nucleotide exchange factors for RhoGTPases: good therapeutic targets for cancer therapy? Cell Signal (2010) 1.20
Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction. J Biol Chem (1994) 1.19
The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells. Sci Signal (2012) 1.17
Crucial structural role for the PH and C1 domains of the Vav1 exchange factor. EMBO Rep (2008) 1.11
Mitogen-activated protein kinase signal transduction in solid tumors. Asian Pac J Cancer Prev (2014) 1.11
Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol (2005) 1.10
The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomas. J Pathol (2003) 1.06
The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis. J Pathol (2009) 1.03
The association of the C-terminal region of beta I sigma II spectrin to brain membranes is mediated by a PH domain, does not require membrane proteins, and coincides with a inositol-1,4,5 triphosphate binding site. Biochem Biophys Res Commun (1995) 1.03
Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity. J Biol Chem (1999) 1.02
Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck. Biochem J (1993) 1.02
Regulation of BCR signaling. Mol Immunol (2010) 1.01
Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter. Mol Cell Biol (2001) 1.01
Vav-1 regulates NK T cell development and NK cell cytotoxicity. Eur J Immunol (2001) 1.00
Antibody-induced engagement of beta 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav. Proc Natl Acad Sci U S A (1996) 0.99
Role for the Rac1 exchange factor Vav in the signaling pathways leading to NK cell cytotoxicity. J Immunol (1999) 0.98
Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies. Cancer Lett (2007) 0.98
Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1. Dev Cell (2013) 0.98
Vav1 as a central regulator of invadopodia assembly. Curr Biol (2013) 0.96
Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization. Exp Cell Res (2005) 0.94
Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK. Immunity (2003) 0.92
The proline-rich region of Vav binds to Grb2 and Grb3-3. Oncogene (1995) 0.92
Vav1: a hematopoietic signal transduction molecule involved in human malignancies. Int J Biochem Cell Biol (2008) 0.92
Single point mutations in the SH2 domain impair the transforming potential of vav and fail to activate proto-vav. Oncogene (1993) 0.92
Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma. Oral Oncol (2007) 0.91
Overexpression of the VAV proto-oncogene product is associated with B-cell chronic lymphocytic leukaemia displaying loss on 13q. Br J Haematol (2006) 0.89
The calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes. J Biol Chem (2007) 0.87
Vav1 modulates protein expression during ATRA-induced maturation of APL-derived promyelocytes: a proteomic-based analysis. J Proteome Res (2008) 0.86
Mutagenic analysis of Vav reveals that an intact SH3 domain is required for transformation. Oncogene (1998) 0.86
EphA receptors regulate prostate cancer cell dissemination through Vav2-RhoA mediated cell-cell repulsion. Biol Open (2014) 0.86
Vav transformation requires activation of multiple GTPases and regulation of gene expression. Mol Cancer Res (2004) 0.86
Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation. FEBS Lett (2000) 0.84
The association of Sam68 with Vav1 contributes to tumorigenesis. Cell Signal (2007) 0.84
Human Vav1 expression in hematopoietic and cancer cell lines is regulated by c-Myb and by CpG methylation. PLoS One (2012) 0.83
Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion. Cancer Res (2015) 0.83
Vav1 in hematologic neoplasms, a mini review. Am J Blood Res (2012) 0.83
Vav1: an oncogene that regulates specific transcriptional activation of T cells. Blood (2003) 0.83