Published in Mol Cell Biol on July 01, 2006
Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer (2010) 5.26
Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol (2010) 2.37
The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting. Mol Cancer Res (2008) 2.21
Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors. J Biol Chem (2008) 1.80
Emerging strategies for EphA2 receptor targeting for cancer therapeutics. Expert Opin Ther Targets (2011) 1.65
The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops. PLoS Biol (2013) 1.50
Eph receptor signaling and ephrins. Cold Spring Harb Perspect Biol (2013) 1.33
Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase. J Biol Chem (2008) 1.24
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. J Cell Biol (2010) 1.24
Bidirectional ephrin/Eph signaling in synaptic functions. Brain Res (2006) 1.22
Function of the nucleotide exchange activity of vav1 in T cell development and activation. Sci Signal (2009) 1.13
Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase. Mol Biol Cell (2009) 1.13
Eph receptors in breast cancer: roles in tumor promotion and tumor suppression. Breast Cancer Res (2008) 1.10
Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function. Mol Cell Biol (2007) 0.99
Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases. Adv Cancer Res (2012) 0.98
The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer. Int Semin Surg Oncol (2008) 0.97
Endothelial EphA receptor stimulation increases lung vascular permeability. Am J Physiol Lung Cell Mol Physiol (2008) 0.96
Vav3-deficient mice exhibit a transient delay in cerebellar development. Mol Biol Cell (2010) 0.96
Novel aspects of the roles of Rac1 GTPase in the cardiovascular system. Curr Opin Pharmacol (2010) 0.95
Major signaling pathways in migrating neuroblasts. Front Mol Neurosci (2009) 0.94
Vav family exchange factors: an integrated regulatory and functional view. Small GTPases (2014) 0.93
Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol Cell Biol (2010) 0.90
Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo. Mol Cancer Res (2009) 0.89
Essential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity. J Neurosci (2011) 0.88
Targeted overexpression of vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate cancer. Cancer Res (2008) 0.88
Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways. Mol Cell Biol (2015) 0.85
Vav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters. Mol Biol Cell (2010) 0.84
EphA2 signaling following endocytosis: role of Tiam1. Traffic (2013) 0.84
Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury. Am J Respir Cell Mol Biol (2012) 0.83
Rho GAPs and GEFs: controling switches in endothelial cell adhesion. Cell Adh Migr (2014) 0.82
Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel-based morphometry and mutation screening. Schizophr Bull (2012) 0.81
Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium. Mol Cancer Res (2014) 0.80
Specificity of HCPTP variants toward EphA2 tyrosines by quantitative selected reaction monitoring. Protein Sci (2011) 0.78
Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration. Mol Biol Cell (2013) 0.78
Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans. Oncotarget (2015) 0.78
Phosphotyrosine profiling identifies ephrin receptor A2 as a potential therapeutic target in esophageal squamous-cell carcinoma. Proteomics (2015) 0.77
Vav1: A Dr. Jekyll and Mr. Hyde protein - good for the hematopoietic system, bad for cancer. Oncotarget (2015) 0.77
Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nat Neurosci (2015) 0.77
Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients. Oncol Lett (2015) 0.77
Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs. Oncogene (2016) 0.75
Thyroid cancer: EphB3 stimulates cell migration and metastasis in a kinase-dependent manner through Vav2-Rho GTPase Axis. J Biol Chem (2016) 0.75
Rho GTPases and the actin cytoskeleton. Science (1998) 28.19
Vascular-specific growth factors and blood vessel formation. Nature (2000) 14.42
Tumorigenesis and the angiogenic switch. Nat Rev Cancer (2003) 11.95
Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell (1998) 10.61
Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol (2005) 7.14
Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol (2002) 6.92
Rho GTPases and cell migration. J Cell Sci (2001) 5.66
Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev (1999) 4.75
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science (1998) 4.41
Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell (1999) 4.17
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron (1996) 4.12
Regulatory and signaling properties of the Vav family. Mol Cell Biol (2000) 3.14
Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science (1995) 2.88
Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron (2005) 2.72
VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol (2002) 2.57
The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene (2000) 2.46
Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. Proc Natl Acad Sci U S A (2000) 2.46
Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene (2002) 2.41
Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. EMBO J (1998) 2.34
Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol Cell Biol (1999) 2.19
Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med (2003) 2.15
Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nat Immunol (2001) 2.03
Vav2 is an activator of Cdc42, Rac1, and RhoA. J Biol Chem (2000) 1.93
Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nat Immunol (2001) 1.93
EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci (2004) 1.82
EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat Cell Biol (2002) 1.72
Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. FASEB J (2005) 1.61
Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr Biol (1998) 1.60
A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene (2005) 1.59
Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol (2000) 1.55
Eph receptor tyrosine kinases in angiogenesis: from development to disease. Angiogenesis (2004) 1.55
Vav proteins, masters of the world of cytoskeleton organization. Cell Signal (2004) 1.52
Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins. Cell Signal (2004) 1.51
Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. J Biol Chem (2000) 1.51
Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell (2005) 1.48
EphB4 controls blood vascular morphogenesis during postnatal angiogenesis. EMBO J (2006) 1.48
Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors. Mol Cell Biol (2000) 1.47
Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist. Cancer Res (2004) 1.44
Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. Mol Cell Biol (2000) 1.40
Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells. Mol Cell Biol (2001) 1.38
Eph receptor tyrosine kinases in tumor and tumor microenvironment. Curr Pharm Des (2004) 1.33
Inhibition of VEGF-dependent multistage carcinogenesis by soluble EphA receptors. Neoplasia (2003) 1.30
Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J Biol Chem (1994) 1.28
Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene (1998) 1.26
EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. J Cell Sci (2003) 1.24
EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Circ Res (2003) 1.23
Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene (2000) 1.21
Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes. J Biol Chem (2002) 1.10
ELK and LERK-2 in developing kidney and microvascular endothelial assembly. Kidney Int Suppl (1996) 1.08
Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors. Gene (2000) 0.94
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc (2007) 5.15
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science (2006) 4.68
Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest (2002) 4.64
Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell (2003) 3.86
Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis. J Bacteriol (2006) 3.23
Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell (2003) 3.11
Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01
An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy. Nat Med (2013) 3.00
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat Med (2011) 2.87
Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA (2012) 2.85
Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol (2008) 2.74
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity (2006) 2.57
Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes (2006) 2.53
Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron (2005) 2.52
The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy (2007) 2.48
Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene (2002) 2.41
Vav3 regulates osteoclast function and bone mass. Nat Med (2005) 2.30
CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron (2002) 2.29
Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med (2003) 2.15
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest (2008) 2.11
Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1. Mol Cell Biol (2003) 1.99
Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol Cancer Res (2002) 1.96
Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. Proc Natl Acad Sci U S A (2012) 1.88
Regulation of osteogenic differentiation during skeletal development. Front Biosci (2008) 1.88
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol (2004) 1.87
Seed size, more than nutrient or tannin content, affects seed caching behavior of a common genus of Old World rodents. Ecology (2009) 1.85
EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci (2004) 1.82
The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev (2002) 1.80
Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol Cell Proteomics (2003) 1.77
Recent advances in tumor-targeting anticancer drug conjugates. Bioorg Med Chem (2005) 1.77
Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron (2012) 1.75
TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. J Biol Chem (2005) 1.75
Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol Biol Cell (2004) 1.73
The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus. Nat Med (2012) 1.72
Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy (2009) 1.67
Molecular and cellular approaches for the detection of protein-protein interactions: latest techniques and current limitations. Plant J (2008) 1.62
Monte Carlo based method for fluorescence tomographic imaging with lifetime multiplexing using time gates. Biomed Opt Express (2011) 1.61
Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. FASEB J (2005) 1.61
A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene (2005) 1.59
Guidance molecules in synapse formation and plasticity. Cold Spring Harb Perspect Biol (2010) 1.56
Eph receptor tyrosine kinases in angiogenesis: from development to disease. Angiogenesis (2004) 1.55
EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics. Curr Cancer Drug Targets (2005) 1.54
BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. J Cell Mol Med (2008) 1.54
Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. Lab Invest (2008) 1.54
Wnt signaling and human diseases: what are the therapeutic implications? Lab Invest (2007) 1.51
Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity (2012) 1.50
Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism. J Cell Sci (2008) 1.48
Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. J Biol Chem (2008) 1.48
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell (2012) 1.48
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest (2007) 1.47
Combining Usability Techniques to Design Geovisualization Tools for Epidemiology. Cartogr Geogr Inf Sci (2005) 1.46
Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron (2010) 1.46
High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome. Metabolism (2007) 1.45
Kidney transplantation in mice using left and right kidney grafts. J Surg Res (2010) 1.44
Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion. Cell Host Microbe (2013) 1.44
Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. J Exp Med (2012) 1.44
Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res (2009) 1.44
Discs large (Dlg1) complexes in lymphocyte activation. J Cell Biol (2004) 1.43
Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation. J Biol Chem (2006) 1.41
The complete genome sequence of Bacillus thuringiensis Al Hakam. J Bacteriol (2007) 1.40
Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity. J Exp Med (2004) 1.39
Predicting mating patterns from pollination syndromes: the case of "sapromyiophily" in Tacca chantrieri (Taccaceae). Am J Bot (2005) 1.36
Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis. J Cell Sci (2002) 1.36
Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci U S A (2006) 1.36
Eph receptor tyrosine kinases in tumor and tumor microenvironment. Curr Pharm Des (2004) 1.33
The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity (2012) 1.33
Full-field time-resolved fluorescence tomography of small animals. Opt Lett (2010) 1.32
A visualization system for space-time and multivariate patterns (VIS-STAMP). IEEE Trans Vis Comput Graph (2006) 1.32
A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Front Physiol (2010) 1.30
Inhibition of VEGF-dependent multistage carcinogenesis by soluble EphA receptors. Neoplasia (2003) 1.30
Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. J Immunol (2006) 1.30
The role of SAP97 in synaptic glutamate receptor dynamics. Proc Natl Acad Sci U S A (2010) 1.30
Design, synthesis, and biological evaluation of new-generation taxoids. J Med Chem (2008) 1.29
High regeneration capacity helps tropical seeds to counter rodent predation. Oecologia (2011) 1.28
Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice. Cancer Res (2006) 1.27
Development of an optical imaging platform for functional imaging of small animals using wide-field excitation. Biomed Opt Express (2010) 1.26
S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease. J Alzheimers Dis (2010) 1.26
Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy. Proc Natl Acad Sci U S A (2011) 1.26
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment. Proc Natl Acad Sci U S A (2013) 1.25
Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase. J Biol Chem (2008) 1.24
Establishment and characterization of a new highly metastatic human osteosarcoma cell line. Clin Exp Metastasis (2009) 1.23
Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization. Sci Signal (2012) 1.23
Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. PLoS One (2011) 1.22
Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol (2006) 1.21
Vav proteins control MyD88-dependent oxidative burst. Blood (2006) 1.19
Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release. Bioconjug Chem (2010) 1.19
Scatter-hoarding rodents prefer slightly astringent food. PLoS One (2011) 1.19
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev (2011) 1.18
Eph receptors and Ephrins in cancer: common themes and controversies. Cancer Res (2008) 1.17
Toward homogeneous erythropoietin: fine tuning of the C-terminal acyl donor in the chemical synthesis of the Cys29-Gly77 glycopeptide domain. J Am Chem Soc (2009) 1.15
Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells. Int J Oncol (2008) 1.15
PP2A activation by beta2-adrenergic receptor agonists: novel regulatory mechanism of keratinocyte migration. J Biol Chem (2003) 1.13
Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase. Mol Biol Cell (2009) 1.13
Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol (2006) 1.12