Published in PLoS One on September 10, 2015
Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes. Interface Focus (2016) 0.77
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet (1963) 16.71
Quantitative estimation of insulin sensitivity. Am J Physiol (1979) 7.37
Mechanisms for insulin resistance: common threads and missing links. Cell (2012) 6.85
In silico preclinical trials: a proof of concept in closed-loop control of type 1 diabetes. J Diabetes Sci Technol (2009) 5.24
Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest (1994) 5.12
Effect of fatty acids on glucose production and utilization in man. J Clin Invest (1983) 4.00
Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab (2009) 3.98
Meal simulation model of the glucose-insulin system. IEEE Trans Biomed Eng (2007) 3.54
Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev (1998) 3.20
Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes (2011) 2.67
Fatty acids, obesity, and insulin resistance: time for a reevaluation. Diabetes (2011) 2.43
The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab (2009) 2.39
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell (2015) 2.20
Postprandial blood glucose as a risk factor for cardiovascular disease in Type II diabetes: the epidemiological evidence. Diabetologia (2001) 2.12
Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol Endocrinol Metab (2003) 1.92
Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes (2000) 1.89
Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. Gastroenterology (2008) 1.78
Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. Diabetes (2004) 1.76
Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. Metabolism (1987) 1.76
Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition? Diabetes (2010) 1.76
A system model of oral glucose absorption: validation on gold standard data. IEEE Trans Biomed Eng (2006) 1.66
Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance. Cell Metab (2012) 1.64
Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J Clin Invest (1996) 1.57
Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology (2013) 1.55
Treating postprandial hyperglycemia does not appear to delay progression of early type 2 diabetes: the Early Diabetes Intervention Program. Diabetes Care (2006) 1.54
Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol Med (2010) 1.48
Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans. Diabetes (1997) 1.30
The postprandial state and risk of cardiovascular disease. Diabet Med (1998) 1.23
Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol (1992) 1.19
Effects of free fatty acids per se on glucose production, gluconeogenesis, and glycogenolysis. Diabetes (2003) 1.17
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans. Proc Natl Acad Sci U S A (2014) 1.15
Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. Am J Physiol Endocrinol Metab (2008) 1.13
The impact of mathematical modeling on the understanding of diabetes and related complications. CPT Pharmacometrics Syst Pharmacol (2013) 1.12
Dynamic modeling of free fatty acid, glucose, and insulin: an extended "minimal model". Diabetes Technol Ther (2006) 1.12
Nuclear magnetic resonance studies of hepatic glucose metabolism in humans. Recent Prog Horm Res (2001) 1.11
Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes. J Biol Chem (2013) 1.11
A hierarchical whole-body modeling approach elucidates the link between in Vitro insulin signaling and in Vivo glucose homeostasis. J Biol Chem (2011) 1.10
Postprandial metabolism of meal triglyceride in humans. Biochim Biophys Acta (2012) 1.09
Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk. Vasc Health Risk Manag (2010) 1.07
The glucose-fatty acid cycle: a physiological perspective. Biochem Soc Trans (2003) 0.97
Postprandial triglyceride-rich lipoprotein metabolism and insulin sensitivity in nonalcoholic steatohepatitis patients. Lipids (2001) 0.95
Conclusions via unique predictions obtained despite unidentifiability--new definitions and a general method. FEBS J (2012) 0.94
Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state. Am J Physiol Endocrinol Metab (2006) 0.94
Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans. Diabetes (2002) 0.92
Tracing the fate of dietary fatty acids: metabolic studies of postprandial lipaemia in human subjects. Proc Nutr Soc (2011) 0.92
Extended effects of evening meal carbohydrate-to-fat ratio on fasting and postprandial substrate metabolism. Am J Clin Nutr (2002) 0.91
A novel minimal model to describe NEFA kinetics following an intravenous glucose challenge. Am J Physiol Regul Integr Comp Physiol (2008) 0.91
Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity. Atherosclerosis (2012) 0.91
Addition of glucose to an oral fat load reduces postprandial free fatty acids and prevents the postprandial increase in complement component 3. Am J Clin Nutr (2004) 0.90
Lipid-induced hepatic insulin resistance. Aging (Albany NY) (2013) 0.90
Fatty acid sources and their fluxes as they contribute to plasma triglyceride concentrations and fatty liver in humans. Curr Opin Lipidol (2014) 0.90
Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans. Metabolism (2001) 0.89
A model of NEFA dynamics with focus on the postprandial state. Ann Biomed Eng (2009) 0.86
Kinetic studies to investigate lipoprotein metabolism. J Intern Med (2012) 0.85
Advancing our understanding of the glucose system via modeling: a perspective. IEEE Trans Biomed Eng (2014) 0.83
Early alterations in the postprandial VLDL1 apoB-100 and apoB-48 metabolism in men with strong heredity for type 2 diabetes. J Intern Med (2004) 0.81
Effects of nonesterified fatty acids on glucose metabolism after glucose ingestion. Diabetes (1997) 0.81
NEFA-glucose comodulation model of beta-cell insulin secretion in 24-h multiple-meal test. Am J Physiol Endocrinol Metab (2007) 0.80
Parameter trajectory analysis to identify treatment effects of pharmacological interventions. PLoS Comput Biol (2013) 0.80
A single mechanism can explain network-wide insulin resistance in adipocytes from obese patients with type 2 diabetes. J Biol Chem (2014) 0.80
A systems biology approach reveals the physiological origin of hepatic steatosis induced by liver X receptor activation. FASEB J (2014) 0.79
Mathematical modelling of hepatic lipid metabolism. Math Biosci (2015) 0.79
Role of free fatty acids and glucagon in the peripheral effect of insulin on glucose production in humans. Am J Physiol (1998) 0.78
Mathematical modeling of glucose homeostasis and its relationship with energy balance and body fat. Obesity (Silver Spring) (2009) 0.77
Pharmacokinetic Modeling of the Glucoregulatory System. J Drug Deliv Sci Technol (2008) 0.76