Published in CPT Pharmacometrics Syst Pharmacol on July 10, 2013
BioModels: ten-year anniversary. Nucleic Acids Res (2014) 1.41
Implementation of quantitative and systems pharmacology in large pharma. CPT Pharmacometrics Syst Pharmacol (2014) 1.00
BioModels: Content, Features, Functionality, and Use. CPT Pharmacometrics Syst Pharmacol (2015) 0.94
Analysis of the efficacy of SGLT2 inhibitors using semi-mechanistic model. Front Pharmacol (2014) 0.86
Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models. Front Pharmacol (2014) 0.82
Autoimmune responses in T1DM: quantitative methods to understand onset, progression, and prevention of disease. Pediatr Diabetes (2014) 0.80
Quasi-Steady-State Analysis based on Structural Modules and Timed Petri Net Predict System's Dynamics: The Life Cycle of the Insulin Receptor. Metabolites (2015) 0.79
Development, growth and maintenance of β-cell mass: models are also part of the story. Mol Aspects Med (2015) 0.79
Effects of IL-1β-Blocking Therapies in Type 2 Diabetes Mellitus: A Quantitative Systems Pharmacology Modeling Approach to Explore Underlying Mechanisms. CPT Pharmacometrics Syst Pharmacol (2014) 0.78
The mathematician's control toolbox for management of type 1 diabetes. Interface Focus (2014) 0.78
A Six-Stage Workflow for Robust Application of Systems Pharmacology. CPT Pharmacometrics Syst Pharmacol (2016) 0.77
Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes. Interface Focus (2016) 0.77
Glucose Homeostatic Law: Insulin Clearance Predicts the Progression of Glucose Intolerance in Humans. PLoS One (2015) 0.77
Cardiovascular disease: the other face of diabetes. CPT Pharmacometrics Syst Pharmacol (2013) 0.76
A Simple Mathematical Model for Wound Closure Evaluation. J Am Coll Clin Wound Spec (2016) 0.75
Paracrine regulation of glucagon secretion: the β/α/δ model. Am J Physiol Endocrinol Metab (2016) 0.75
The promises of quantitative systems pharmacology modelling for drug development. Comput Struct Biotechnol J (2016) 0.75
Model-Based Quantification of the Systemic Interplay between Glucose and Fatty Acids in the Postprandial State. PLoS One (2015) 0.75
Disease Progression Modeling: Key Concepts and Recent Developments. Curr Pharmacol Rep (2016) 0.75
Use and abuse of HOMA modeling. Diabetes Care (2004) 16.97
Quantitative estimation of insulin sensitivity. Am J Physiol (1979) 7.37
Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest (1981) 5.82
BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol (2010) 5.75
Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes. Physiol Meas (2004) 5.65
Meal simulation model of the glucose-insulin system. IEEE Trans Biomed Eng (2007) 3.54
A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling. J Clin Invest (1972) 2.20
Diabetes: Models, Signals, and Control. IEEE Rev Biomed Eng (2009) 2.11
Emergence of organized bursting in clusters of pancreatic beta-cells by channel sharing. Biophys J (1988) 2.03
Prehepatic insulin production in man: kinetic analysis using peripheral connecting peptide behavior. J Clin Endocrinol Metab (1980) 1.99
A mathematical model of metabolic insulin signaling pathways. Am J Physiol Endocrinol Metab (2002) 1.86
Minimal model of beta-cell mitochondrial Ca2+ handling. Am J Physiol (1997) 1.80
Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion. Am J Physiol Endocrinol Metab (2007) 1.77
Calcium and glycolysis mediate multiple bursting modes in pancreatic islets. Biophys J (2004) 1.68
Mass and information feedbacks through receptor endocytosis govern insulin signaling as revealed using a parameter-free modeling framework. J Biol Chem (2010) 1.45
Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus. Clin Pharmacokinet (2008) 1.44
Computer model for mechanisms underlying ultradian oscillations of insulin and glucose. Am J Physiol (1991) 1.43
Coefficients of normal blood glucose regulation. J Appl Physiol (1961) 1.43
A model of beta-cell mass, insulin, and glucose kinetics: pathways to diabetes. J Theor Biol (2000) 1.39
Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation. Mol Syst Biol (2009) 1.33
Models of subcutaneous insulin kinetics. A critical review. Comput Methods Programs Biomed (2000) 1.32
Mathematical modelling of the intravenous glucose tolerance test. J Math Biol (2000) 1.27
The phantom burster model for pancreatic beta-cells. Biophys J (2000) 1.23
A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells. Biophys J (1995) 1.18
Insulin receptor binding kinetics: modeling and simulation studies. J Theor Biol (2000) 1.17
A model of phosphofructokinase and glycolytic oscillations in the pancreatic beta-cell. Biophys J (2003) 1.14
A hierarchical whole-body modeling approach elucidates the link between in Vitro insulin signaling and in Vivo glucose homeostasis. J Biol Chem (2011) 1.10
Channel sharing in pancreatic beta -cells revisited: enhancement of emergent bursting by noise. J Theor Biol (2000) 1.09
A critical review of mathematical models and data used in diabetology. Biomed Eng Online (2006) 1.08
[Further studies on the dynamic aspects of insulin release in vitro with evidence for a two-compartmental storage system]. Acta Diabetol Lat (1969) 1.08
Assessment of insulin sensitivity in vivo: a critical review. Diabetes Metab Rev (1989) 1.06
Modeling the insulin-glucose feedback system: the significance of pulsatile insulin secretion. J Theor Biol (2000) 1.06
Effects of extracellular calcium on electrical bursting and intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cells. Biophys J (1997) 1.06
A model of glucose-insulin homeostasis in man that incorporates the heterogeneous fast pool theory of pancreatic insulin release. Diabetes (1978) 1.03
Cellular modeling: insight into oral minimal models of insulin secretion. Am J Physiol Endocrinol Metab (2009) 1.01
An integrated model for glucose and insulin regulation in healthy volunteers and type 2 diabetic patients following intravenous glucose provocations. J Clin Pharmacol (2007) 0.96
Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism. PLoS Comput Biol (2012) 0.96
Mathematical modeling and analysis of insulin clearance in vivo. BMC Syst Biol (2008) 0.94
Insulin signaling - mathematical modeling comes of age. Trends Endocrinol Metab (2012) 0.94
Onset of type 1 diabetes: a dynamical instability. Diabetes (1999) 0.94
A composite computational model of liver glucose homeostasis. I. Building the composite model. J R Soc Interface (2011) 0.92
Dynamical complexity and temporal plasticity in pancreatic beta-cells. J Biosci (2000) 0.91
Mathematical modeling in glucose metabolism and insulin secretion. Curr Opin Clin Nutr Metab Care (2002) 0.90
A kinetic core model of the glucose-stimulated insulin secretion network of pancreatic beta cells. Mamm Genome (2007) 0.88
A simulation model of extracellular glucose distribution in the human body. Ann Biomed Eng (1975) 0.88
Mathematical models of diabetes progression. Am J Physiol Endocrinol Metab (2008) 0.88
Theory of the effect of extracellular potassium on oscillations in the pancreatic beta-cell. Biophys J (1985) 0.87
A molecular mathematical model of glucose mobilization and uptake. Math Biosci (2009) 0.87
Modeling the effects of treating diabetic wounds with engineered skin substitutes. Wound Repair Regen (2007) 0.86
Macrophage dynamics in diabetic wound dealing. Bull Math Biol (2006) 0.86
Mathematical models of energy homeostasis. J R Soc Interface (2008) 0.85
Modelling the onset of Type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease? Philos Trans A Math Phys Eng Sci (2006) 0.85
Glucose sensing in the pancreatic beta cell: a computational systems analysis. Theor Biol Med Model (2010) 0.85
Evidence that calcium release-activated current mediates the biphasic electrical activity of mouse pancreatic beta-cells. J Membr Biol (1997) 0.84
Modeling approaches to type 2 diabetes. Diabetes Technol Ther (2004) 0.83
A mathematical model and computer simulation study of insulin receptor regulation. J Theor Biol (1991) 0.83
Putting the pieces together in diabetes research: towards a hierarchical model of whole-body glucose homeostasis. Eur J Pharm Sci (2008) 0.82
Pancreatic network control of glucagon secretion and counterregulation. Methods Enzymol (2009) 0.82
Optimizing reduction in basal hyperglucagonaemia to repair defective glucagon counterregulation in insulin deficiency. Diabetes Obes Metab (2011) 0.82
Quantification of beta-cell function during IVGTT in Type II and non-diabetic subjects: assessment of insulin secretion by mathematical methods. Diabetologia (2001) 0.82
Kinetic modeling of human hepatic glucose metabolism in type 2 diabetes mellitus predicts higher risk of hypoglycemic events in rigorous insulin therapy. J Biol Chem (2012) 0.81
Contributions of mathematical modeling of beta cells to the understanding of beta-cell oscillations and insulin secretion. J Diabetes Sci Technol (2009) 0.81
MATHEMATICAL MODELS OF SUBCUTANEOUS INJECTION OF INSULIN ANALOGUES: A MINI-REVIEW. Discrete Continuous Dyn Syst Ser B (2009) 0.81
A mathematical model of brain glucose homeostasis. Theor Biol Med Model (2009) 0.80
Bariatric surgery and T2DM improvement mechanisms: a mathematical model. Theor Biol Med Model (2012) 0.78
Diffusion induced oscillatory insulin secretion. Bull Math Biol (2001) 0.78
Mathematical modeling of glucose homeostasis and its relationship with energy balance and body fat. Obesity (Silver Spring) (2009) 0.77
Mathematical models for insulin secretion in pancreatic β-cells. Islets (2012) 0.77
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics (2003) 32.92
Nicotinic receptors at the amino acid level. Annu Rev Pharmacol Toxicol (2000) 4.04
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature (1995) 3.28
Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis. Nat Cell Biol (2000) 3.27
International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev (1999) 2.76
Conformational spread in a ring of proteins: a stochastic approach to allostery. J Mol Biol (2001) 2.52
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature (1999) 2.13
The identity of plant glutamate receptors. Science (2001) 1.53
Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems. J Neurosci (1995) 1.38
Brain nicotinic receptors: structure and regulation, role in learning and reinforcement. Brain Res Brain Res Rev (1998) 1.30
Localization of nAChR subunit mRNAs in the brain of Macaca mulatta. Eur J Neurosci (2000) 1.29
Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons. Proc Natl Acad Sci U S A (1999) 1.15
Acute and long-term changes in the mesolimbic dopamine pathway after systemic or local single nicotine injections. Eur J Neurosci (2002) 1.06
Promoter elements conferring neuron-specific expression of the beta 2-subunit of the neuronal nicotinic acetylcholine receptor studied in vitro and in transgenic mice. Neuroscience (1995) 1.04
Control of neurulation by the nucleosome assembly protein-1-like 2. Nat Genet (2000) 0.98
Enhanced hemicholinium binding and attenuated dendrite branching in cognitively impaired acetylcholinesterase-transgenic mice. J Neurochem (1997) 0.95
The Input Signal Step Function (ISSF), a standard method to encode input signals in SBML models with software support, applied to circadian clock models. J Biol Rhythms (2012) 0.87
SysBioMed report: advancing systems biology for medical applications. IET Syst Biol (2009) 0.86
Nicotinic receptors and brain plasticity. Cold Spring Harb Symp Quant Biol (1996) 0.78
Effects of buflomedil hydrochloride in occlusive arterial disease of the lower limbs stage IV. J Int Med Res (1986) 0.75