Stamping out RAF and MEK1/2 to inhibit the ERK1/2 pathway: an emerging threat to anticancer therapy.

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Published in Oncogene on September 14, 2015

Authors

R Mandal1,2,3, S Becker1, K Strebhardt1,2,3

Author Affiliations

1: German Cancer Consortium (DKTK), Heidelberg, Germany.
2: Department of Gynaecology and Obstetrics, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
3: German Cancer Research Center (DKFZ), Heidelberg, Germany.

Associated clinical trials:

Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212 | NCT01072175

A Phase III Study Comparing Vemurafenib vs Vemurafenib Plus Cobimetinib (GDC-0973) in Patients With Metastatic Melanoma (coBRIM) | NCT01689519

A Phase Ib Study of MEK162 Plus BYL719 in Adult Patients With Selected Advanced Solid Tumors | NCT01449058

A Study to Evaluate RAF265, an Oral Drug Administered to Subjects With Locally Advanced or Metastatic Melanoma (CHIR-265-MEL01) | NCT00304525

BRAF/MEK/EGFR Inhibitor Combination Study in Colorectal Cancer (CRC) | NCT01750918

Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With Erlotinib in KRAS Wild Type Advanced Non-Small Cell Lung Cancer (NSCLC) and a Randomized Phase II Study of AZD6244 With Erlotinib in Mutant KRAS Adva... | NCT01229150

Clinical Study Of PI3K/mTOR Inhibitors In Combination With An Oral MEK Inhibitor Or Irinotecan In Patients With Advanced Cancer | NCT01347866

A Study of the BRAF Inhibitor Dabrafenib in Combination With the MEK Inhibitor Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma After Surgical Resection. (COMBI-AD) | NCT01682083

LGX818 in Combination With Agents (MEK162; BKM120; LEE011; BGJ398; INC280) in Advanced BRAF Melanoma (LOGIC) | NCT01820364

Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer | NCT01719380

Safety and Efficacy Study of BMS-908662 Alone or in Combination With Cetuximab in Subjects With K-RAS or B-RAF Mutation Positive Advanced or Metastatic Colorectal Cancer | NCT01086267

PALBOCICLIB + PD-0325901 for NSCLC & Solid Tumors | NCT02022982

Akt Inhibitor GSK2141795, Dabrafenib, and Trametinib in Treating Patients With Stage IIIC-IV Cancer | NCT01902173

MEK162 and RAF265 in Adult Patients With Advanced Solid Tumors Harboring RAS or BRAFV600E Mutations | NCT01352273

A Phase I Study of Oral LGX818 in Adult Patients With Advanced or Metastatic BRAF Mutant Melanoma | NCT01436656

A Study of ARRY-438162 (MEK162) in Patients With Advanced Cancer | NCT00959127

Study of TAK-733 in Adult Patients With Advanced Nonhematologic Malignancies | NCT00948467

Vemurafenib in Combination With Everolimus or Temsirolimus With Advanced Cancer | NCT01596140

A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GDC-0973 in Combination With GDC-0068 When Administered in Participants With Locally Advanced or Metastatic Solid Tumors | NCT01562275

Study of TAK-733 in Combination With Alisertib in Adult Patients With Advanced Nonhematologic Malignancies | NCT01613261

Phase II Trial of Pimasertib Versus Dacarbazine in N-Ras Mutated Cutaneous Melanoma | NCT01693068

MEK Inhibitor MSC1936369B Plus FOLFIRI in Second Line K-Ras Mutated Metastatic Colorectal Cancer (mCRC) | NCT01085331

A Dose-Escalating Study of RO4987655 in Patients With Advanced Solid Tumors | NCT00817518

Assessing BAY86-9766 Plus Sorafenib for the Treatment of Liver Cancer. (BASIL) | NCT01204177

A Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of E6201 in Subjects With Advanced Solid Tumors | NCT00794781

Trial of Gemcitabine With or Without MSC1936369B in Pancreatic Cancer | NCT01016483

Sorafenib Tosylate With or Without Recombinant Interferon Alfa-2b in Treating Patients With Metastatic Kidney Cancer | NCT00126594

AZD8330 First Time in Man in Patients With Advanced Malignancies | NCT00454090

Safety and Efficacy Study of BMS-908662 in Combination With Ipilimumab in Subjects With Advanced Melanoma | NCT01245556

Phase I/II Dose-escalation Study to Investigate Safety and Pharmacokinetics/ Pharmacodynamics of WX-554 in Patients With Solid Tumours | NCT01581060

Sorafenib Tosylate in Treating Patients With Metastatic, Locally Advanced, or Recurrent Medullary Thyroid Cancer | NCT00390325

Study of Selumetinib (AZD6244)(ARRY-142886) in Combination With Irinotecan in Previously Treated Patients With Colorec | NCT01116271

LGX818 for Patients With BRAFV600 Mutated Tumors (SIGNATURE) | NCT01981187

A Study of MEHD7945A and Cobimetinib in Patients With Locally Advanced or Metastatic Cancers With Mutant KRAS | NCT01986166

MSC2015103B in Solid Tumors | NCT01453387

Combination With Gemcitabine in Advanced Pancreatic Cancer (BAGPAC) | NCT01251640

Selumetinib and Cixutumumab in Treating Patients With Advanced Solid Malignancies | NCT01061749

Refametinib (BAY86-9766) in Combination With Regorafenib (Stivarga, BAY73-4506) in Patients With Advanced or Metastatic Cancer | NCT02168777

AZD6244 (Selumetinib) in Treating Patients With Multiple Myeloma | NCT01085214

A Dose-Escalation Study of RO5126766 in Patients With Advanced Solid Tumors. | NCT00773526

MEK Inhibitor MEK162, Idarubicin, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia | NCT02049801

Tipifarnib and Sorafenib Tosylate in Treating Patients With Biopsiable Advanced Cancer | NCT00244972

Study of Vemurafenib, Carboplatin, and Paclitaxel | NCT01636622

A Study of Cobimetinib in Combination With Paclitaxel as First-line Treatment for Patients With Metastatic Triple-negative Breast Cancer | NCT02322814

GSK1120212+GSK2141795 for Cervical Cancer | NCT01958112

Efficacy and Safety of LGX818 in Patients With Advanced or Metastatic BRAF V600 Mutant NSCLC | NCT02109653

Phase I Trial of RO5126766 (DDU RAF/MEK) | NCT02407509

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