RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models.

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🔗 View Article (PMID 20551065)

Published in Cancer Res on June 15, 2010

Authors

Hong Yang1, Brian Higgins, Kenneth Kolinsky, Kathryn Packman, Zenaida Go, Raman Iyer, Stanley Kolis, Sylvia Zhao, Richard Lee, Joseph F Grippo, Kathleen Schostack, Mary Ellen Simcox, David Heimbrook, Gideon Bollag, Fei Su

Author Affiliations

1: Discovery Oncology, Hoffmann-La Roche, Inc., Nutley, New Jersey, USA.

Associated clinical trials:

Study of the Combination Vemurafenib Plus PEG-interferon in Advanced Melanoma Patients Harboring the V600BRAF Mutation (VEMUPLINT) | NCT01959633

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