Chimeric antigen receptor-modified T cells derived from defined CD8(+) and CD4(+) subsets confer superior antitumor reactivity in vivo.

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Published in Leukemia on September 15, 2015

Authors

D Sommermeyer1, M Hudecek1,2, P L Kosasih1, T Gogishvili2, D G Maloney1,3, C J Turtle1,3, S R Riddell1,3,4

Author Affiliations

1: Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
2: Department of Medicine II - Hematology and Medical Oncology, University of Würzburg, Würzburg, Germany.
3: Department of Medicine, University of Washington, Seattle, WA, USA.
4: Institute for Advanced Study, Technical University of Munich, Munich, Germany.

Associated clinical trials:

Laboratory Treated T Cells in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma, or Acute Lymphoblastic Leukemia | NCT01865617

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