The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.

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Published in Cancer Immunol Res on September 11, 2014

Authors

Michael Hudecek1, Daniel Sommermeyer2, Paula L Kosasih2, Anne Silva-Benedict3, Lingfeng Liu2, Christoph Rader4, Michael C Jensen5, Stanley R Riddell6

Author Affiliations

1: Fred Hutchinson Cancer Research Center, Clinical Research Division, Program in Immunology, Seattle, Washington. University of Würzburg, Department of Medicine II - Hematology and Medical Oncology, Würzburg, Germany.
2: Fred Hutchinson Cancer Research Center, Clinical Research Division, Program in Immunology, Seattle, Washington.
3: Seattle Children's Research Institute, Ben Towne Center for Childhood Cancer Research, Seattle, Washington. Department of Medicine, University of Washington, Seattle, Washington.
4: Department of Cancer Biology, The Scripps Research Institute, Jupiter, Florida. Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida.
5: Fred Hutchinson Cancer Research Center, Clinical Research Division, Program in Immunology, Seattle, Washington. Seattle Children's Research Institute, Ben Towne Center for Childhood Cancer Research, Seattle, Washington. Department of Pediatrics, University of Washington, Seattle, Washington.
6: Fred Hutchinson Cancer Research Center, Clinical Research Division, Program in Immunology, Seattle, Washington. Department of Medicine, University of Washington, Seattle, Washington. Technical University of Munich, Institute for Advanced Study, Munich, Germany. sriddell@fhcrc.org.

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