Published in J Cell Physiol on October 14, 2015
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature (2009) 5.34
Haematopoietic stem cells derive directly from aortic endothelium during development. Nature (2010) 4.42
Continuous single-cell imaging of blood generation from haemogenic endothelium. Nature (2009) 4.32
Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell (2008) 4.17
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature (2010) 4.16
Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature (2010) 4.14
Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nat Immunol (2008) 4.04
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature (2009) 3.88
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood (2007) 3.71
Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res (2011) 3.58
Control of globin gene expression during development and erythroid differentiation. Exp Hematol (2005) 3.47
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat Biotechnol (2007) 2.65
Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells. Nat Biotechnol (2014) 2.05
RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. Blood (2013) 2.00
T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.99
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition. Blood (2012) 1.87
Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer. Blood (2007) 1.82
Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells. Cell Stem Cell (2011) 1.76
Scl is required for dorsal aorta as well as blood formation in zebrafish embryos. Blood (2005) 1.76
Advances in the understanding of haemoglobin switching. Br J Haematol (2010) 1.74
Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells. Blood (2009) 1.73
Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro. Blood (2002) 1.72
The OP9-DL1 system: generation of T-lymphocytes from embryonic or hematopoietic stem cells in vitro. Cold Spring Harb Protoc (2009) 1.66
Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.46
Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell (2012) 1.43
Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro. Stem Cells (2006) 1.39
Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells. Blood (2010) 1.37
Primitive and definitive erythropoiesis in mammals. Front Physiol (2014) 1.34
Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nat Cell Biol (2015) 1.16
Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells. Blood (2013) 1.14
TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy. Cell Res (2011) 1.12
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. J Clin Invest (2015) 1.08
BMP4 regulates vascular progenitor development in human embryonic stem cells through a Smad-dependent pathway. J Cell Biochem (2010) 1.08
Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells. Blood (2010) 1.06
Scalable expansion of human induced pluripotent stem cells in the defined xeno-free E8 medium under adherent and suspension culture conditions. Stem Cell Res (2013) 1.02
Embryonic origin of human hematopoiesis. Int J Dev Biol (2010) 1.00
Tenascin C promotes hematoendothelial development and T lymphoid commitment from human pluripotent stem cells in chemically defined conditions. Stem Cell Reports (2014) 0.99
Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms. Development (2013) 0.90
Identification of the niche and phenotype of the first human hematopoietic stem cells. Stem Cell Reports (2014) 0.87
The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate. Leukemia (2015) 0.86
The balance of positive and negative effects of TGF-β signaling regulates the development of hematopoietic and endothelial progenitors in human pluripotent stem cells. Stem Cells Dev (2013) 0.82
Cooperative Effect of Erythropoietin and TGF-β Inhibition on Erythroid Development in Human Pluripotent Stem Cells. J Cell Biochem (2015) 0.77
Epithelial-Mesenchymal Transition (EMT): A Biological Process in the Development, Stem Cell Differentiation and Tumorigenesis. J Cell Physiol (2017) 0.78
Cooperative Effect of Erythropoietin and TGF-β Inhibition on Erythroid Development in Human Pluripotent Stem Cells. J Cell Biochem (2015) 0.77
Arrhythmogenic risks of stem cell replacement therapy for cardiovascular diseases. J Cell Physiol (2020) 0.75