Published in Blood on August 03, 2009
Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood (2011) 3.43
Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting. Blood (2011) 3.21
NK cell-based immunotherapy for malignant diseases. Cell Mol Immunol (2013) 2.39
Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood (2011) 2.24
Maturing reticulocytes internalize plasma membrane in glycophorin A-containing vesicles that fuse with autophagosomes before exocytosis. Blood (2012) 2.03
Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region. J Exp Med (2011) 1.25
Signalling pathways that control vertebrate haematopoietic stem cell specification. Nat Rev Immunol (2013) 1.21
Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nat Cell Biol (2015) 1.16
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Clinical-scale derivation of natural killer cells from human pluripotent stem cells for cancer therapy. Stem Cells Transl Med (2013) 1.14
Skeletal stem cells. Development (2015) 1.11
Improving the outcome of leukemia by natural killer cell-based immunotherapeutic strategies. Front Immunol (2014) 1.10
Production of Gene-Corrected Adult Beta Globin Protein in Human Erythrocytes Differentiated from Patient iPSCs After Genome Editing of the Sickle Point Mutation. Stem Cells (2015) 1.07
Generation of HIV-1 resistant and functional macrophages from hematopoietic stem cell-derived induced pluripotent stem cells. Mol Ther (2010) 1.03
Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms. J Virol (2010) 1.01
Pluripotent stem cell-based cancer therapy: promise and challenges. Sci Transl Med (2012) 0.99
Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL. Haematologica (2014) 0.96
NK cells in therapy of cancer. Crit Rev Oncog (2014) 0.96
Natural killer cells for cancer immunotherapy: pluripotent stem cells-derived NK cells as an immunotherapeutic perspective. Front Immunol (2014) 0.95
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Pluripotent stem cell-derived natural killer cells for cancer therapy. Transl Res (2010) 0.93
Unique differentiation profile of mouse embryonic stem cells in rotary and stirred tank bioreactors. Tissue Eng Part A (2010) 0.90
Identification of the niche and phenotype of the first human hematopoietic stem cells. Stem Cell Reports (2014) 0.87
Therapeutic effect of human iPS-cell-derived myeloid cells expressing IFN-β against peritoneally disseminated cancer in xenograft models. PLoS One (2013) 0.86
Jak-STAT regulation of cyst stem cell development in the Drosophila testis. Dev Biol (2012) 0.86
Expression of chimeric receptor CD4ζ by natural killer cells derived from human pluripotent stem cells improves in vitro activity but does not enhance suppression of HIV infection in vivo. Stem Cells (2014) 0.85
Understanding of molecular mechanisms in natural killer cell therapy. Exp Mol Med (2015) 0.84
Generating human hematopoietic stem cells in vitro -exploring endothelial to hematopoietic transition as a portal for stemness acquisition. FEBS Lett (2016) 0.84
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Differential sensitivity to JAK inhibitory drugs by isogenic human erythroblasts and hematopoietic progenitors generated from patient-specific induced pluripotent stem cells. Stem Cells (2014) 0.83
Gene correction in patient-specific iPSCs for therapy development and disease modeling. Hum Genet (2016) 0.83
Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects. Stem Cell Reports (2016) 0.82
Amyotrophic lateral sclerosis - cell based therapy and novel therapeutic development. Exp Neurobiol (2014) 0.82
Specific marking of hESCs-derived hematopoietic lineage by WAS-promoter driven lentiviral vectors. PLoS One (2012) 0.82
Engineered human embryonic stem cell-derived lymphocytes to study in vivo trafficking and immunotherapy. Stem Cells Dev (2013) 0.81
Pluripotent stem cells in research and treatment of hemoglobinopathies. Cold Spring Harb Perspect Med (2012) 0.81
Progress towards generation of human haematopoietic stem cells. Nat Cell Biol (2016) 0.81
Development, expansion, and in vivo monitoring of human NK cells from human embryonic stem cells (hESCs) and and induced pluripotent stem cells (iPSCs). J Vis Exp (2013) 0.80
Generation of CD34+ cells from human embryonic stem cells using a clinically applicable methodology and engraftment in the fetal sheep model. Exp Hematol (2013) 0.79
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells. Stem Cells (2015) 0.79
Endothelial reconstitution by CD34+ progenitors derived from baboon embryonic stem cells. J Cell Mol Med (2013) 0.79
A synthetic substrate to support early mesodermal differentiation of human embryonic stem cells. Biomaterials (2011) 0.78
Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells. PLoS One (2015) 0.78
Pluripotent stem cell applications for regenerative medicine. Curr Opin Organ Transplant (2015) 0.78
miR-451 Up-regulation, Induce Erythroid Differentiation of CD133+cells Independent of Cytokine Cocktails. Iran J Basic Med Sci (2013) 0.77
Concise review: programming human pluripotent stem cells into blood. Br J Haematol (2016) 0.77
Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells. Stem Cells Transl Med (2016) 0.76
A synthetic three-dimensional niche system facilitates generation of functional hematopoietic cells from human-induced pluripotent stem cells. J Hematol Oncol (2016) 0.76
Definitive Hematopoietic Multipotent Progenitor Cells Are Transiently Generated From Hemogenic Endothelial Cells in Human Pluripotent Stem Cells. J Cell Physiol (2015) 0.75
Lent-On-Plus Lentiviral vectors for conditional expression in human stem cells. Sci Rep (2016) 0.75
Methotrexate supports in vivo selection of human embryonic stem cell derived-hematopoietic cells expressing dihydrofolate reductase. Bioeng Bugs (2011) 0.75
Experimental approaches to derive CD34+ progenitors from human and nonhuman primate embryonic stem cells. Am J Stem Cells (2015) 0.75
Cytokine-free directed differentiation of human pluripotent stem cells efficiently produces hemogenic endothelium with lymphoid potential. Stem Cell Res Ther (2017) 0.75
Induced Pluripotent Stem Cell for the Study and Treatment of Sickle Cell Anemia. Stem Cells Int (2017) 0.75
OP9 Feeder Cells Are Superior to M2-10B4 Cells for the Generation of Mature and Functional Natural Killer Cells from Umbilical Cord Hematopoietic Progenitors. Front Immunol (2017) 0.75
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Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63
Human induced pluripotent stem cells free of vector and transgene sequences. Science (2009) 17.16
Disease-specific induced pluripotent stem cells. Cell (2008) 16.95
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21
Generation of mouse induced pluripotent stem cells without viral vectors. Science (2008) 15.25
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (2008) 14.26
Induced pluripotent stem cells generated without viral integration. Science (2008) 13.38
Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A (2008) 13.09
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21
Hematopoiesis: an evolving paradigm for stem cell biology. Cell (2008) 11.95
Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell (2009) 11.65
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature (2009) 11.27
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol (2008) 10.63
Of mice and not men: differences between mouse and human immunology. J Immunol (2004) 10.61
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol (2008) 10.60
Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science (2008) 10.55
Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell (2009) 10.52
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol (2008) 10.29
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36
Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature (2009) 9.29
Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA (2008) 8.60
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med (2006) 7.21
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Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature (1999) 6.23
Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19
HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell (2002) 5.71
Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci (2005) 5.66
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature (2009) 5.37
Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res (2003) 5.12
Generation of induced pluripotent stem cells from human blood. Blood (2009) 4.92
Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90
Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A (2008) 4.48
Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood (2004) 4.32
Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A (2001) 4.07
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood (2003) 3.98
Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells. Nat Biotechnol (2004) 3.76
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood (2007) 3.71
The promise of human induced pluripotent stem cells for research and therapy. Nat Rev Mol Cell Biol (2008) 3.56
Control of globin gene expression during development and erythroid differentiation. Exp Hematol (2005) 3.47
Hematopoietic and endothelial differentiation of human induced pluripotent stem cells. Stem Cells (2009) 3.46
Sarcoma derived from cultured mesenchymal stem cells. Stem Cells (2006) 3.40
Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nat Immunol (2004) 3.33
Evidence for discrete stages of human natural killer cell differentiation in vivo. J Exp Med (2006) 3.29
Multilineage differentiation from human embryonic stem cell lines. Stem Cells (2001) 3.22
Helix-loop-helix proteins and lymphocyte development. Nat Immunol (2005) 3.13
Biologic properties and enucleation of red blood cells from human embryonic stem cells. Blood (2008) 3.01
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Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell (2008) 2.74
Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation. Blood (2005) 2.69
Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Blood (2006) 2.66
New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell (2008) 2.61
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J Exp Med (2005) 2.42
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Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells. Blood (2008) 2.36
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Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts. Proc Natl Acad Sci U S A (2008) 2.25
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors. Blood (2008) 2.24
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Phenotypic correction of murine hemophilia A using an iPS cell-based therapy. Proc Natl Acad Sci U S A (2009) 2.02
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Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globin. Blood (2006) 1.95
Yolk-sac hematopoiesis: the first blood cells of mouse and man. Exp Hematol (2001) 1.83
Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood (2007) 1.79
Good manufacturing practice and clinical-grade human embryonic stem cell lines. Hum Mol Genet (2008) 1.76
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Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity. J Immunol (2005) 1.67
Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development. Exp Hematol (2005) 1.65
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Hematopoietic engraftment of human embryonic stem cell-derived cells is regulated by recipient innate immunity. Stem Cells (2006) 1.64
Large-scale production of embryonic red blood cells from human embryonic stem cells. Exp Hematol (2006) 1.61
Donor cell leukemia: insight into cancer stem cells and the stem cell niche. Blood (2007) 1.61
Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity. Blood (2009) 1.57
Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3. Exp Hematol (2008) 1.52
Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells. Blood (2006) 1.51
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Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function. J Thromb Haemost (2006) 1.45
VEGF-A165 augments erythropoietic development from human embryonic stem cells. Blood (2003) 1.43
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Functional antigen-presenting leucocytes derived from human embryonic stem cells in vitro. Lancet (2004) 1.42
Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation. Biotechnol Bioeng (2006) 1.40
Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5. Proc Natl Acad Sci U S A (2003) 1.40
Directed differentiation of human embryonic stem cells into functional dendritic cells through the myeloid pathway. J Immunol (2006) 1.34
Stem cell medicine encounters the immune system. Nat Rev Immunol (2002) 1.34
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A feeder-free and efficient production of functional neutrophils from human embryonic stem cells. Stem Cells (2009) 1.24
Human embryonic stem cell-derived hematopoietic cells are capable of engrafting primary as well as secondary fetal sheep recipients. Blood (2005) 1.23
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