Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.

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Published in Acta Neuropathol on September 23, 2015

Authors

David Castel1,2, Cathy Philippe1, Raphaël Calmon3, Ludivine Le Dret1, Nathalène Truffaux1, Nathalie Boddaert3, Mélanie Pagès4, Kathryn R Taylor5, Patrick Saulnier6, Ludovic Lacroix6, Alan Mackay5, Chris Jones5, Christian Sainte-Rose7, Thomas Blauwblomme7, Felipe Andreiuolo4, Stephanie Puget7, Jacques Grill8,9, Pascale Varlet4, Marie-Anne Debily10,11

Author Affiliations

1: UMR8203 "Vectorologie et Thérapeutiques Anticancéreuses", CNRS, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France.
2: Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France.
3: Département de Neuroradiologie, INSERM U1000, "Imagerie et Psychiatrie", Hôpital Necker-Enfants Malades, Université Paris V Descartes, Paris, 75015, France.
4: Département de Neuropathologie, Hôpital Sainte-Anne, Université Paris V Descartes, Paris, 75014, France.
5: Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
6: Département de Biologie et de Pathologie Médicale, Laboratoire de Recherche Translationnelle, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, Villejuif, 94805, France.
7: Département de Neurochirurgie Pédiatrique, Hôpital Necker-Enfants Malades, Université Paris V Descartes, Paris, 75015, France.
8: UMR8203 "Vectorologie et Thérapeutiques Anticancéreuses", CNRS, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France. jacques.grill@gustaveroussy.fr.
9: Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France. jacques.grill@gustaveroussy.fr.
10: UMR8203 "Vectorologie et Thérapeutiques Anticancéreuses", CNRS, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, 94805, Villejuif, France. marie-anne.debily@gustaveroussy.fr.
11: Département de Biologie, Université Evry Val-d'Essonne, 91037, Evry, France. marie-anne.debily@gustaveroussy.fr.

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