Published in ACS Chem Biol on October 21, 2015
Natural Products and the Gene Cluster Revolution. Trends Microbiol (2016) 0.81
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites. Nat Prod Rep (2016) 0.80
Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites. Beilstein J Org Chem (2016) 0.78
Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids. Cell Chem Biol (2016) 0.78
Antibiotic drug discovery. Microb Biotechnol (2016) 0.76
Phylogenomic Insight into Salinispora (Bacteria, Actinobacteria) Species Designations. Sci Rep (2017) 0.75
Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology. Chromosoma (2016) 0.75
Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase. Beilstein J Org Chem (2016) 0.75
Breaking the silence: new strategies for discovering novel natural products. Curr Opin Biotechnol (2017) 0.75
Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials. Mar Drugs (2017) 0.75
Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds. Front Microbiol (2017) 0.75
Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations. Mar Drugs (2017) 0.75
OrthoMCL: identification of ortholog groups for eukaryotic genomes. Genome Res (2003) 33.03
Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat Methods (2009) 22.47
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. Proc Natl Acad Sci U S A (2003) 10.30
Sampling the antibiotic resistome. Science (2006) 7.27
The biological cost of antibiotic resistance. Curr Opin Microbiol (1999) 6.08
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining. Nat Chem Biol (2005) 3.17
High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes. FEMS Microbiol Lett (1997) 3.00
New antibiotics from bacterial natural products. Nat Biotechnol (2006) 2.72
Fix the antibiotics pipeline. Nature (2011) 2.67
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell (2014) 2.59
Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting. Nat Biotechnol (2012) 2.54
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J Biol Chem (2000) 2.39
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proc Natl Acad Sci U S A (2011) 2.05
A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol (2011) 2.05
Culturable marine actinomycete diversity from tropical Pacific Ocean sediments. Environ Microbiol (2005) 2.02
Identifying producers of antibacterial compounds by screening for antibiotic resistance. Nat Biotechnol (2013) 2.02
Acetoacetyl-acyl carrier protein synthase. A target for the antibiotic thiolactomycin. J Biol Chem (1989) 1.89
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A (2014) 1.78
Essentiality of FASII pathway for Staphylococcus aureus. Nature (2010) 1.77
Selective isolation of genomic loci from complex genomes by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae. Nat Protoc (2008) 1.75
The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA. Nat Chem (2014) 1.70
Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins. Science (2015) 1.63
New natural product biosynthetic chemistry discovered by genome mining. Nat Prod Rep (2009) 1.60
Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Proc Natl Acad Sci U S A (2014) 1.56
Discovery of FabH/FabF inhibitors from natural products. Antimicrob Agents Chemother (2006) 1.51
Discovery of microbial natural products by activation of silent biosynthetic gene clusters. Nat Rev Microbiol (2015) 1.45
Mechanism of action of the antibiotic thiolactomycin inhibition of fatty acid synthesis of Escherichia coli. Biochem Biophys Res Commun (1983) 1.44
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. Antimicrob Agents Chemother (2000) 1.40
Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB. J Bacteriol (1993) 1.38
Molecular mechanisms of antibiotic resistance. Chem Commun (Camb) (2011) 1.33
Antibiotics: natural products essential to human health. Med Res Rev (2009) 1.27
DNA sequence elements required for transcription initiation of the Schizosaccharomyces pombe ADH gene in Saccharomyces cerevisiae. Mol Gen Genet (1990) 1.25
Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics. Angew Chem Int Ed Engl (2010) 1.22
Thiolactomycin, a new antibiotic. II. Structure elucidation. J Antibiot (Tokyo) (1982) 1.19
Inhibition of fatty acid synthesis by the antibiotic thiolactomycin. J Antibiot (Tokyo) (1984) 1.17
Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proc Natl Acad Sci U S A (2011) 1.15
Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proc Natl Acad Sci U S A (2013) 1.12
The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. Nat Prod Rep (2015) 1.11
Identification of a napsamycin biosynthesis gene cluster by genome mining. Chembiochem (2010) 1.09
The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. Chembiochem (2011) 1.07
How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics. J Biol Chem (2015) 0.99
A general cloning system to selectively isolate any eukaryotic or prokaryotic genomic region in yeast. BMC Genomics (2003) 0.97
The re-emerging role of microbial natural products in antibiotic discovery. Antonie Van Leeuwenhoek (2014) 0.91
A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli. Antimicrob Agents Chemother (2002) 0.91
Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. ACS Chem Biol (2011) 0.90
Streptomyces coelicolor as an expression host for heterologous gene clusters. Methods Enzymol (2012) 0.88
Biosynthetic origins of the natural product, thiolactomycin: a unique and selective inhibitor of type II dissociated fatty acid synthases. J Am Chem Soc (2003) 0.87
Mining the metabiome: identifying novel natural products from microbial communities. Chem Biol (2014) 0.86
C-S bond cleavage by a polyketide synthase domain. Proc Natl Acad Sci U S A (2015) 0.80
FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus. Antimicrob Agents Chemother (2014) 0.78
Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains. Chem Biol (2014) 0.78
A metabolomics guided exploration of marine natural product chemical space. Metabolomics (2016) 0.75