Published in J Biol Chem on May 05, 1989
Iso- and anteiso-fatty acids in bacteria: biosynthesis, function, and taxonomic significance. Microbiol Rev (1991) 5.59
Regulation of fatty acid biosynthesis in Escherichia coli. Microbiol Rev (1993) 5.09
EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB. J Bacteriol (1995) 2.99
beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis. J Bacteriol (2000) 2.10
The structural basis of acyl coenzyme A-dependent regulation of the transcription factor FadR. EMBO J (2001) 1.95
Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold. EMBO J (2000) 1.69
Intrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems. Antimicrob Agents Chemother (1998) 1.68
Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis. J Bacteriol (1998) 1.64
Overproduction of beta-ketoacyl-acyl carrier protein synthase I imparts thiolactomycin resistance to Escherichia coli K-12. J Bacteriol (1992) 1.57
Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis. Antimicrob Agents Chemother (1996) 1.57
Bacterial lipids: metabolism and membrane homeostasis. Prog Lipid Res (2013) 1.42
Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB. J Bacteriol (1993) 1.38
3-Ketoacyl-acyl carrier protein synthase III from spinach (Spinacia oleracea) is not similar to other condensing enzymes of fatty acid synthase. Plant Physiol (1993) 1.38
Response of Bacillus subtilis to cerulenin and acquisition of resistance. J Bacteriol (2001) 1.23
Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus. Antimicrob Agents Chemother (2002) 1.14
Relationships between fatty acid and polyketide synthases from Streptomyces coelicolor A3(2): characterization of the fatty acid synthase acyl carrier protein. J Bacteriol (1996) 1.13
Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus. Protein Sci (2005) 1.05
Changes in the size and composition of intracellular pools of nonesterified coenzyme A and coenzyme A thioesters in aerobic and facultatively anaerobic bacteria. Appl Environ Microbiol (1997) 1.01
'FAS't inhibition of malaria. Biochem J (2004) 1.01
The Lactococcus lactis FabF fatty acid synthetic enzyme can functionally replace both the FabB and FabF proteins of Escherichia coli and the FabH protein of Lactococcus lactis. Arch Microbiol (2008) 0.95
In vivo and in vitro effects of thiolactomycin on fatty acid biosynthesis in Streptomyces collinus. J Bacteriol (1997) 0.95
The fabJ-encoded beta-ketoacyl-[acyl carrier protein] synthase IV from Escherichia coli is sensitive to cerulenin and specific for short-chain substrates. Proc Natl Acad Sci U S A (1994) 0.95
Cloning of a cDNA encoding 3-ketoacyl-acyl carrier protein synthase III from Arabidopsis. Plant Physiol (1994) 0.91
A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli. Antimicrob Agents Chemother (2002) 0.91
Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase. Protein Sci (2007) 0.87
Response of fatty acid synthesis genes to the binding of human salivary amylase by Streptococcus gordonii. Appl Environ Microbiol (2012) 0.84
Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents. J Med Chem (2009) 0.84
Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. ACS Chem Biol (2015) 0.83
The role of beta-ketoacyl-acyl carrier protein synthase III in the condensation steps of fatty acid biosynthesis in sunflower. Planta (2010) 0.81
Using modern tools to probe the structure-function relationship of fatty acid synthases. Chembiochem (2015) 0.80
Bacterial fatty acid metabolism in modern antibiotic discovery. Biochim Biophys Acta (2016) 0.77
Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase. Bioorg Med Chem (2014) 0.77
Drugs in development for toxoplasmosis: advances, challenges, and current status. Drug Des Devel Ther (2017) 0.75
In silico screening for Plasmodium falciparum enoyl-ACP reductase inhibitors. J Comput Aided Mol Des (2014) 0.75
Reaction mechanism of recombinant 3-oxoacyl-(acyl-carrier-protein) synthase III from Cuphea wrightii embryo, a fatty acid synthase type II condensing enzyme. Biochem J (2000) 0.75
Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography. Proc Natl Acad Sci U S A (1997) 5.39
Regulation of fatty acid biosynthesis in Escherichia coli. Microbiol Rev (1993) 5.09
Metabolism and function of the membrane phospholipids of Escherichia coli. Biochim Biophys Acta (1972) 3.84
Regulation of coenzyme A biosynthesis. J Bacteriol (1981) 3.68
Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein. Proc Natl Acad Sci U S A (1996) 3.35
Evidence for two genes specifically involved in unsaturated fatty acid biosynthesis in Escherichia coli. J Bacteriol (1969) 3.35
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery. Annu Rev Microbiol (2001) 3.35
Physical properties of membrane lipids: biological relevance and regulation. Bacteriol Rev (1975) 3.18
Phospholipid alterations during growth of Escherichia coli. J Bacteriol (1968) 3.09
Acyl homoserine-lactone quorum-sensing signal generation. Proc Natl Acad Sci U S A (1999) 3.07
Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli. J Biol Chem (1995) 2.80
The gene encoding the biotin carboxylase subunit of Escherichia coli acetyl-CoA carboxylase. J Biol Chem (1992) 2.79
Selection and characterization of an E. coli mutant defective in membrane lipid biosynthesis. Proc Natl Acad Sci U S A (1970) 2.78
Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis. J Biol Chem (1998) 2.75
Cyclopropane ring formation in membrane lipids of bacteria. Microbiol Mol Biol Rev (1997) 2.71
Mapping of the fabA locus for unsaturated fatty acid biosynthesis in Escherichia coli. J Bacteriol (1972) 2.63
Escherichia coli mutants with altered control of alcohol dehydrogenase and nitrate reductase. J Bacteriol (1980) 2.61
Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res (2001) 2.60
Preparative enzymatic synthesis and hydrophobic chromatography of acyl-acyl carrier protein. J Biol Chem (1979) 2.48
Acyl carrier protein from Escherichia coli. Methods Enzymol (1981) 2.44
A triclosan-resistant bacterial enzyme. Nature (2000) 2.40
Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli. J Biol Chem (1980) 2.40
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J Biol Chem (2000) 2.39
Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12. J Biol Chem (1992) 2.35
Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem (1999) 2.34
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis. J Biol Chem (2000) 2.33
Beta-alanine synthesis in Escherichia coli. J Bacteriol (1980) 2.27
A new mechanism of transcriptional regulation: release of an activator triggered by small molecule binding. Cell (1992) 2.21
Acetoacetyl-acyl carrier protein synthase, a potential regulator of fatty acid biosynthesis in bacteria. J Biol Chem (1987) 2.19
Molecular biology of bacterial membrane lipids. Annu Rev Biochem (1978) 2.17
Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis. Biochim Biophys Acta (1996) 2.12
beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis. J Bacteriol (2000) 2.10
Membrane cyclopropane fatty acid content is a major factor in acid resistance of Escherichia coli. Mol Microbiol (1999) 2.06
Overproduction of acetyl-CoA carboxylase activity increases the rate of fatty acid biosynthesis in Escherichia coli. J Biol Chem (2000) 2.05
Regulation of pantothenate kinase by coenzyme A and its thioesters. J Biol Chem (1987) 2.04
The gene encoding Escherichia coli acyl carrier protein lies within a cluster of fatty acid biosynthetic genes. J Biol Chem (1992) 2.04
Temperature-sensitive mutants of Escherichia coli requiring saturated and unsaturated fatty acids for growth: isolation and properties. Proc Natl Acad Sci U S A (1972) 2.03
Mutants of Escherichia coli with temperature-sensitive lesions in membrane phospholipid synthesis: genetic analysis of glycerol-3-phosphate acyltransferase mutants. Mol Gen Genet (1972) 2.02
Regulation of phospholipid synthesis in Escherichia coli. Composition of the acyl-acyl carrier protein pool in vivo. J Biol Chem (1982) 2.02
Ratio of active to inactive forms of acyl carrier protein in Escherichia coli. J Biol Chem (1983) 2.02
Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis. J Biol Chem (1980) 2.01
The enzymatic biotinylation of proteins: a post-translational modification of exceptional specificity. Trends Biochem Sci (1999) 2.00
A mutant of Escherichia coli auxotrophic for organic phosphates: evidence for two defects in inorganic phosphate transport. Mol Gen Genet (1975) 1.98
Genomic replacement in Escherichia coli K-12 using covalently closed circular plasmid DNA. Gene (1990) 1.98
Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics. Appl Microbiol Biotechnol (2002) 1.96
Inhibition of beta-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli. J Biol Chem (1996) 1.93
Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. J Biol Chem (2000) 1.93
Isolation and characterization of Escherichia coli pantothenate permease (panF) mutants. J Bacteriol (1985) 1.92
Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis. J Biol Chem (1996) 1.89
The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli. Structure (2000) 1.88
Genetic and biochemical analyses of pantothenate biosynthesis in Escherichia coli and Salmonella typhimurium. J Bacteriol (1982) 1.88
Regulation of fatty acid elongation and initiation by acyl-acyl carrier protein in Escherichia coli. J Biol Chem (1996) 1.87
Mapping nonselectable genes of Escherichia coli by using transposon Tn10: location of a gene affecting pyruvate oxidase. J Bacteriol (1982) 1.86
Psychological aggression predicts physical aggression in early marriage. J Consult Clin Psychol (1989) 1.85
The genes encoding the two carboxyltransferase subunits of Escherichia coli acetyl-CoA carboxylase. J Biol Chem (1992) 1.82
Growth rate regulation of Escherichia coli acetyl coenzyme A carboxylase, which catalyzes the first committed step of lipid biosynthesis. J Bacteriol (1993) 1.80
Metabolism of 4'-phosphopantetheine in Escherichia coli. J Bacteriol (1984) 1.78
Acetaldehyde coenzyme A dehydrogenase of Escherichia coli. J Bacteriol (1980) 1.78
Mutants of Escherichia coli defective in membrane phospholipid synthesis: mapping of the structural gene for L-glycerol 3-phosphate dehydrogenase. J Bacteriol (1974) 1.77
The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli. J Biol Chem (2001) 1.76
Inhibition of fatty acid synthesis in Escherichia coli in the absence of phospholipid synthesis and release of inhibition by thioesterase action. J Bacteriol (1994) 1.76
A Bacillus subtilis gene induced by cold shock encodes a membrane phospholipid desaturase. J Bacteriol (1998) 1.75
A conserved histidine is essential for glycerolipid acyltransferase catalysis. J Bacteriol (1998) 1.75
Mutants of Escherichia coli defective in membrane phospholipid synthesis: mapping of sn-glycerol 3-phosphate acyltransferase Km mutants. J Bacteriol (1974) 1.74
Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product. J Biol Chem (1994) 1.73
Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase. EMBO J (1990) 1.72
Improved purification of acyl carrier protein. Anal Biochem (1980) 1.70
Defective export of a periplasmic enzyme disrupts regulation of fatty acid synthesis. J Biol Chem (1995) 1.69
Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J Biol Chem (2000) 1.69
Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic gene. J Bacteriol (2001) 1.68
Coordination of membrane phospholipid synthesis with the cell cycle. J Biol Chem (1994) 1.67
Altered molecular form of acyl carrier protein associated with beta-ketoacyl-acyl carrier protein synthase II (fabF) mutants. J Bacteriol (1987) 1.67
Thermal regulation of membrane fluidity in Escherichia coli. Effects of overproduction of beta-ketoacyl-acyl carrier protein synthase I. J Biol Chem (1983) 1.66
Genetic and biochemical analyses of Escherichia coli strains having a mutation in the structural gene (poxB) for pyruvate oxidase. J Bacteriol (1983) 1.66
Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. Biochemistry (2000) 1.64
Lipoic acid metabolism in Escherichia coli: the lplA and lipB genes define redundant pathways for ligation of lipoyl groups to apoprotein. J Bacteriol (1995) 1.64
Diffusion tensor imaging in Alzheimer's disease and mild cognitive impairment. Behav Neurol (2009) 1.63
Thioesterases I and II of Escherichia coli. Hydrolysis of native acyl-acyl carrier protein thioesters. J Biol Chem (1978) 1.63
The unmodified (apo) form of Escherichia coli acyl carrier protein is a potent inhibitor of cell growth. J Biol Chem (1995) 1.61
In vivo evidence that S-adenosylmethionine and fatty acid synthesis intermediates are the substrates for the LuxI family of autoinducer synthases. J Bacteriol (1998) 1.61
Mutant of Escherichia coli deficient in the synthesis of cis-vaccenic acid. J Bacteriol (1972) 1.61
Bacillus subtilis acyl carrier protein is encoded in a cluster of lipid biosynthesis genes. J Bacteriol (1996) 1.60
Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation. J Mol Biol (1991) 1.58
Processing of the N termini of nascent polypeptide chains requires deformylation prior to methionine removal. J Mol Biol (1999) 1.57
Overproduction of beta-ketoacyl-acyl carrier protein synthase I imparts thiolactomycin resistance to Escherichia coli K-12. J Bacteriol (1992) 1.57
Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis. Biochemistry (2001) 1.57
Isolation and characterization of Saccharomyces cerevisiae mutants defective in glycerol catabolism. J Bacteriol (1977) 1.57
Expression of Escherichia coli pyruvate oxidase (PoxB) depends on the sigma factor encoded by the rpoS(katF) gene. Mol Microbiol (1994) 1.55
Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III. J Biol Chem (2000) 1.54
A new metabolic link. The acyl carrier protein of lipid synthesis donates lipoic acid to the pyruvate dehydrogenase complex in Escherichia coli and mitochondria. J Biol Chem (1997) 1.53
Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem (1995) 1.52
Re-evaluation of the solution structure of acyl carrier protein. J Biol Chem (1979) 1.50
A role for phospholipid hydrolysis in the lysis of Escherichia coli infected with bacteriophage T4. Virology (1969) 1.49
Preparative enzymatic synthesis of acyl-acyl carrier protein. Methods Enzymol (1981) 1.49