Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 26468775)

Published in Nat Commun on October 15, 2015

Authors

Lishan Fang1,2, Junchao Cai1,2, Baixue Chen1,2, Shanshan Wu1,2, Rong Li1,2, Xiaonan Xu1,2, Yi Yang2,3, Hongyu Guan4, Xun Zhu1,2, Le Zhang1,2, Jie Yuan2,5, Jueheng Wu1,2, Mengfeng Li1,2

Author Affiliations

1: Department of Microbiology, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
2: Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, Guangdong 510080, China.
3: Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
4: Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
5: Key Laboratory of Functional Molecules from Oceanic Microorganisms, Sun Yat-sen University, Department of Education of Guangdong Province, Guangzhou, Guangdong 510080, China.

Associated clinical trials:

A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection | NCT01829971

Neoadjuvant Study of In-situ REIC/Dkk-3 in Prostate Cancer | NCT01197209

Pre-operative Decitabine in Colon Cancer: a Proof of Principle Study (DECO) | NCT01882660

Articles citing this

Wnt signaling in cancer. Oncogene (2016) 0.95

Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer. J Hum Genet (2016) 0.75

Articles cited by this

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46

Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88

Cancer statistics, 2013. CA Cancer J Clin (2013) 84.72

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer (2008) 18.08

Wnt/β-catenin signaling and disease. Cell (2012) 16.05

"Stemness": transcriptional profiling of embryonic and adult stem cells. Science (2002) 15.55

Tumour stem cells and drug resistance. Nat Rev Cancer (2005) 15.21

Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell (2005) 15.06

MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods (2007) 13.94

MicroRNAs in Cancer. Annu Rev Med (2009) 9.37

Secreted antagonists of the Wnt signalling pathway. J Cell Sci (2003) 8.02

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol (2010) 7.73

Analysis of gene expression data using BRB-ArrayTools. Cancer Inform (2007) 6.09

Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state. Nat Biotechnol (2007) 5.36

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol (2010) 4.22

WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell (2009) 3.76

Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol (1998) 3.29

Wnt signaling pathway in non-small cell lung cancer. J Natl Cancer Inst (2013) 3.24

Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell (2012) 2.89

Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res (2010) 2.67

Cancer stem cells and self-renewal. Clin Cancer Res (2010) 2.37

Can we safely target the WNT pathway? Nat Rev Drug Discov (2014) 2.31

Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling. J Biol Chem (2000) 2.24

The Wnt antagonist sFRP1 in colorectal tumorigenesis. Cancer Res (2004) 2.16

Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene (2003) 1.93

Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. Cancer Res (2007) 1.81

MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. J Clin Invest (2013) 1.76

Notch in lung development and lung cancer. Semin Cancer Biol (2004) 1.73

MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5. BMC Cancer (2012) 1.61

Dickkopf-3/REIC functions as a suppressor gene of tumor growth. Oncogene (2004) 1.60

MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop. J Clin Invest (2011) 1.60

APC mutations are infrequent but present in human lung cancer. Cancer Lett (2004) 1.57

IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease. J Allergy Clin Immunol (2007) 1.54

Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity. Cell Stem Cell (2012) 1.50

Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis. Scand J Immunol (2008) 1.49

Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer. Oncogene (2005) 1.48

MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways. Oncogene (2011) 1.48

Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer. Cancer Lett (2011) 1.48

Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis (2007) 1.46

MiR-214 targets β-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma. PLoS One (2012) 1.42

Reduced expression of the REIC/Dkk-3 gene by promoter-hypermethylation in human tumor cells. Gene (2002) 1.34

Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma. Genes Chromosomes Cancer (2001) 1.32

Reduced expression of REIC/Dkk-3 gene in non-small cell lung cancer. Int J Oncol (2001) 1.32

Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis (2008) 1.29

miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer. Cancer Res (2013) 1.27

A high throughput experimental approach to identify miRNA targets in human cells. Nucleic Acids Res (2009) 1.24

Loss of miR-101 expression promotes Wnt/β-catenin signalling pathway activation and malignancy in colon cancer cells. J Pathol (2012) 1.22

Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. BMC Cancer (2009) 1.19

Therapeutic effects of microRNA-582-5p and -3p on the inhibition of bladder cancer progression. Mol Ther (2013) 1.19

Tumor recurrence after complete resection for non-small cell lung cancer. Ann Thorac Surg (2012) 1.18

Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type beta-catenin nuclear accumulation in lung tumorigenesis. Oncogene (2008) 1.01

Retinoic acid-inducible gene-I mediates late phase induction of TNF-alpha by lipopolysaccharide. J Immunol (2008) 0.94

Rapid pulmonary fibrosis induced by acute lung injury via a lipopolysaccharide three-hit regimen. Innate Immun (2009) 0.90

Targeted cancer stem cell therapies start with proper identification of the target. Mol Cancer Res (2010) 0.82

Genetic variants of the Wnt signaling pathway as predictors of recurrence and survival in early-stage non-small cell lung cancer patients. Carcinogenesis (2014) 0.80