Published in Nat Methods on August 12, 2007
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature (2009) 14.07
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature (2010) 13.82
Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell (2011) 10.50
Long noncoding RNAs: functional surprises from the RNA world. Genes Dev (2009) 9.14
Natural RNA circles function as efficient microRNA sponges. Nature (2013) 8.93
Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54
Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A (2008) 6.89
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67
lincRNAs: genomics, evolution, and mechanisms. Cell (2013) 6.50
The functional role of long non-coding RNA in human carcinomas. Mol Cancer (2011) 6.37
Roles for microRNAs in conferring robustness to biological processes. Cell (2012) 6.32
Pervasive roles of microRNAs in cardiovascular biology. Nature (2011) 6.08
Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov (2010) 6.07
MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol (2009) 5.92
An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell (2011) 5.75
miR-21: a small multi-faceted RNA. J Cell Mol Med (2009) 5.59
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol (2011) 5.57
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med (2012) 5.46
MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet (2012) 5.38
Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA (2012) 5.16
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol (2010) 4.80
CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res (2010) 4.68
MicroRNAs in cancer. Annu Rev Pathol (2009) 4.47
MicroRNA functions in stress responses. Mol Cell (2010) 4.46
The multilayered complexity of ceRNA crosstalk and competition. Nature (2014) 4.15
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med (2009) 4.03
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron (2010) 3.96
MicroRNAs can generate thresholds in target gene expression. Nat Genet (2011) 3.90
Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol (2013) 3.80
The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ. Nat Immunol (2011) 3.77
Stable knockdown of microRNA in vivo by lentiviral vectors. Nat Methods (2008) 3.55
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol (2009) 3.48
Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA. Science (2010) 3.45
MiRNAs and cancer. Am J Pathol (2009) 3.42
Target mRNA abundance dilutes microRNA and siRNA activity. Mol Syst Biol (2010) 3.37
MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov (2013) 3.33
Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ Res (2008) 3.18
MicroRNA: implications for cancer. Virchows Arch (2007) 3.17
MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells (2010) 3.16
MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths. Mol Biol Cell (2008) 3.10
Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nat Rev Genet (2009) 3.09
Experimental strategies for microRNA target identification. Nucleic Acids Res (2011) 3.00
Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem (2010) 2.99
MicroRNA sponges: progress and possibilities. RNA (2010) 2.96
MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell (2013) 2.92
Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. Mol Cell (2014) 2.83
Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem (2008) 2.81
Detecting and characterizing circular RNAs. Nat Biotechnol (2014) 2.73
A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell Stem Cell (2013) 2.68
Emerging roles for natural microRNA sponges. Curr Biol (2010) 2.62
High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries. Nat Methods (2012) 2.62
The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis. RNA Biol (2009) 2.56
Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells. Curr Biol (2011) 2.53
Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells. Nucleic Acids Res (2009) 2.52
MicroRNAs and cardiac pathology. Nat Rev Cardiol (2009) 2.50
Retracted HMGA2 functions as a competing endogenous RNA to promote lung cancer progression. Nature (2013) 2.47
The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nat Neurosci (2015) 2.37
Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol Cell (2011) 2.33
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells. Nat Struct Mol Biol (2013) 2.33
Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms. Nat Methods (2009) 2.32
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A (2011) 2.21
Construction of Parallel Analysis of RNA Ends (PARE) libraries for the study of cleaved miRNA targets and the RNA degradome. Nat Protoc (2009) 2.12
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell (2012) 2.07
Inhibition of microRNA function by antimiR oligonucleotides. Silence (2012) 2.02
A collection of target mimics for comprehensive analysis of microRNA function in Arabidopsis thaliana. PLoS Genet (2010) 2.01
Expression of versican 3'-untranslated region modulates endogenous microRNA functions. PLoS One (2010) 1.94
miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates. RNA (2007) 1.90
MiR-210--micromanager of the hypoxia pathway. Trends Mol Med (2010) 1.90
Adult-specific functions of animal microRNAs. Nat Rev Genet (2013) 1.89
SeqBuster, a bioinformatic tool for the processing and analysis of small RNAs datasets, reveals ubiquitous miRNA modifications in human embryonic cells. Nucleic Acids Res (2009) 1.88
Vigilance and validation: Keys to success in RNAi screening. ACS Chem Biol (2010) 1.85
microRNA-21 regulates astrocytic response following spinal cord injury. J Neurosci (2012) 1.85
Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus. J Virol (2010) 1.83
Micro RNAs of Epstein-Barr virus promote cell cycle progression and prevent apoptosis of primary human B cells. PLoS Pathog (2010) 1.80
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79
MicroRNAs and their role in progressive kidney diseases. Clin J Am Soc Nephrol (2009) 1.77
MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1. Nat Commun (2013) 1.76
The role of miRNAs in regulating gene expression networks. J Mol Biol (2013) 1.74
MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes. J Biol Chem (2011) 1.70
RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol (2012) 1.69
Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods (2012) 1.67
MicroRNAs as a therapeutic target for cardiovascular diseases. J Cell Mol Med (2009) 1.67
MicroRNAs associated with metastatic prostate cancer. PLoS One (2011) 1.66
Viruses and microRNAs: RISCy interactions with serious consequences. Genes Dev (2011) 1.66
Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes. Genome Res (2008) 1.66
MicroRNAs shape the neuronal landscape. Neuron (2012) 1.64
A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest. J Virol (2010) 1.64
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer. Theranostics (2015) 1.62
MicroRNA therapeutics. Gene Ther (2011) 1.61
miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nat Commun (2013) 1.59
Metastamirs: a stepping stone towards improved cancer management. Nat Rev Clin Oncol (2010) 1.58
Progress in microRNA delivery. J Control Release (2013) 1.58
miR-132 mediates the integration of newborn neurons into the adult dentate gyrus. PLoS One (2011) 1.52
A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest (2014) 1.52
miR-221 silencing blocks hepatocellular carcinoma and promotes survival. Cancer Res (2011) 1.51
Causes and consequences of microRNA dysregulation. Cancer J (2012) 1.51
Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. Sci Rep (2014) 1.50
Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology. PLoS One (2008) 1.49
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
Prediction of mammalian microRNA targets. Cell (2003) 53.70
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
siRNAs can function as miRNAs. Genes Dev (2003) 16.08
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell (2007) 14.58
MicroRNA-133 controls cardiac hypertrophy. Nat Med (2007) 11.68
miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell (2007) 9.08
Sequence-specific inhibition of small RNA function. PLoS Biol (2004) 7.98
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA (2004) 7.71
MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues. Genome Res (2004) 6.98
Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev (2007) 4.79
microRNA modulation of circadian-clock period and entrainment. Neuron (2007) 4.49
LNA-modified oligonucleotides mediate specific inhibition of microRNA function. Gene (2006) 3.49
Improved targeting of miRNA with antisense oligonucleotides. Nucleic Acids Res (2006) 3.43
Localized expression of small RNA inhibitors in human cells. Mol Ther (2003) 1.78
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
Predictive identification of exonic splicing enhancers in human genes. Science (2002) 16.86
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
siRNAs can function as miRNAs. Genes Dev (2003) 16.08
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
Embryonic stem cell-specific MicroRNAs. Dev Cell (2003) 13.05
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science (2008) 11.33
Divergent transcription from active promoters. Science (2008) 11.03
Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33
Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07
Gene silencing in mammals by small interfering RNAs. Nat Rev Genet (2002) 7.80
Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol (2003) 7.38
Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A (2008) 6.89
Short RNAs repress translation after initiation in mammalian cells. Mol Cell (2006) 6.70
siRNA-directed inhibition of HIV-1 infection. Nat Med (2002) 6.36
Roles for microRNAs in conferring robustness to biological processes. Cell (2012) 6.32
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
miRNA profiling of naïve, effector and memory CD8 T cells. PLoS One (2007) 5.43
RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2007) 5.26
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature (2006) 4.80
Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev (2007) 4.79
MicroRNA functions in stress responses. Mol Cell (2010) 4.46
Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc Natl Acad Sci U S A (2006) 4.02
The RNAi revolution. Nature (2004) 3.96
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron (2010) 3.96
MicroRNAs can generate thresholds in target gene expression. Nat Genet (2011) 3.90
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell (2004) 3.71
RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Nucleic Acids Res (2004) 3.70
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci U S A (2003) 3.48
Gene silencing using micro-RNA designed hairpins. RNA (2002) 3.21
microRNAs: a safeguard against turmoil? Cell (2007) 3.11
14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature (2007) 2.98
Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature (2006) 2.96
MicroRNA sponges: progress and possibilities. RNA (2010) 2.96
Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nat Struct Mol Biol (2011) 2.85
Single nucleotide polymorphism-based validation of exonic splicing enhancers. PLoS Biol (2004) 2.77
Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proc Natl Acad Sci U S A (2013) 2.75
Characterization of a highly variable eutherian microRNA gene. RNA (2005) 2.72
Research data in the digital age. Science (2009) 2.65
Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Nature (2013) 2.63
Zcchc11-dependent uridylation of microRNA directs cytokine expression. Nat Cell Biol (2009) 2.63
Emerging roles for natural microRNA sponges. Curr Biol (2010) 2.62
Divergent transcription: a new feature of active promoters. Cell Cycle (2009) 2.50
Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol Cell (2011) 2.33
Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. J Virol (2003) 2.26
Comparison of siRNA-induced off-target RNA and protein effects. RNA (2007) 2.22
Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes Dev (2005) 2.16
A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails. Genes Dev (2012) 2.13
RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes. Mol Cell Biol (2003) 2.07
1918 flu and responsible science. Science (2005) 2.05
Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Cancer Cell (2012) 2.04
Calcium signalling in lymphocytes. Curr Opin Immunol (2003) 2.00
Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Mol Cell Biol (2006) 1.99
Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. J Clin Invest (2004) 1.95
Small interfering RNA-mediated gene silencing in T lymphocytes. J Immunol (2002) 1.90
A system for Cre-regulated RNA interference in vivo. Proc Natl Acad Sci U S A (2008) 1.87
The calcineurin phosphatase complex modulates immunogenic B cell responses. Immunity (2006) 1.83
Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy. J Biol Chem (2004) 1.82
Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Mol Cell (2006) 1.81
Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome. Proc Natl Acad Sci U S A (2011) 1.77
Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. J Exp Med (2012) 1.76
The role of miRNAs in regulating gene expression networks. J Mol Biol (2013) 1.74
A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev (2006) 1.60
Molecular biology. A circuitous route to noncoding RNA. Science (2013) 1.47
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Proc Natl Acad Sci U S A (2002) 1.45
Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proc Natl Acad Sci U S A (2011) 1.33
Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest (2006) 1.33
A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. PLoS Genet (2011) 1.31
tRNAs marked with CCACCA are targeted for degradation. Science (2011) 1.30
Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Mol Cell Biol (2004) 1.30
Functional delivery of siRNA in mice using dendriworms. ACS Nano (2009) 1.27
MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice. Blood (2011) 1.26
Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle. J Biol Chem (2004) 1.23
The octamer binding transcription factor Oct-1 is a stress sensor. Cancer Res (2005) 1.22
Divergent transcription: a driving force for new gene origination? Cell (2013) 1.20
Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proc Natl Acad Sci U S A (2010) 1.20
In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs. RNA (2012) 1.20
The discovery of split genes and RNA splicing. Trends Biochem Sci (2005) 1.19
Rbfox2 controls autoregulation in RNA-binding protein networks. Genes Dev (2014) 1.18
Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature (2007) 1.17
Characterization of the short RNAs bound by the P19 suppressor of RNA silencing in mouse embryonic stem cells. RNA (2006) 1.13
Effect of nanoparticle conjugation on gene silencing by RNA interference. J Am Chem Soc (2010) 1.11
Small RNA regulators of gene expression. Cell (2008) 1.10
Regulation of immunoglobulin promoter activity by TFII-I class transcription factors. J Biol Chem (2003) 1.09
PDCD2 is a negative regulator of HCF-1 (C1). Oncogene (2002) 1.08
B cell development and immunoglobulin transcription in Oct-1-deficient mice. Proc Natl Acad Sci U S A (2004) 1.03
Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proc Natl Acad Sci U S A (2005) 1.02
Herpes simplex virus infections are arrested in Oct-1-deficient cells. Proc Natl Acad Sci U S A (2004) 1.01
RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2008) 0.98
Genome-wide impact of a recently expanded microRNA cluster in mouse. Proc Natl Acad Sci U S A (2011) 0.92
Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts. Genes Dev (2013) 0.91
Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities. Adv Exp Med Biol (2013) 0.88
Transcription-dependent polyubiquitination of RNA polymerase II requires lysine 63 of ubiquitin. Biochemistry (2004) 0.88
Herpesviruses throw a curve ball: new insights into microRNA biogenesis and evolution. Nat Methods (2005) 0.84