Systematic review regarding metabolic profiling for improved pathophysiological understanding of disease and outcome prediction in respiratory infections.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 4608151)

Published in Respir Res on October 15, 2015

Authors

Manuela Nickler1, Manuel Ottiger2, Christian Steuer3, Andreas Huber4, Janet Byron Anderson5, Beat Müller6, Philipp Schuetz7,8

Author Affiliations

1: Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland. Manuela.Nickler@ksa.ch.
2: Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland. Manuel.Ottiger@ksa.ch.
3: Department of Laboratory Medicine, Kantonsspital Aarau, Aarau, Switzerland. Christian.Steuer@ksa.ch.
4: Department of Laboratory Medicine, Kantonsspital Aarau, Aarau, Switzerland. Andreas.Huber@ksa.ch.
5: Principal, Medical Linguistics Consulting, North Olmsted, OH, USA. medlinguistics@sbcglobal.net.
6: Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland. happy.mueller@unibas.ch.
7: Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland. schuetzph@gmail.com.
8: University Department of Medicine, Kantonsspital Aarau, Tellstrasse, CH-5001, Aarau, Switzerland. schuetzph@gmail.com.

Articles cited by this

(truncated to the top 100)

A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med (1997) 24.87

The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med (2004) 18.60

Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49

The L-arginine-nitric oxide pathway. N Engl J Med (1993) 14.38

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol (1996) 13.14

IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol (2004) 10.08

Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med (2001) 9.08

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med (2013) 8.21

Deaths: final data for 2005. Natl Vital Stat Rep (2008) 7.50

The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med (1995) 6.17

Systematic functional analysis of the yeast genome. Trends Biotechnol (1998) 5.69

Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65

Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33

Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med (2006) 4.15

Concentrations of choline-containing compounds and betaine in common foods. J Nutr (2003) 4.12

Metabolomics: a global biochemical approach to drug response and disease. Annu Rev Pharmacol Toxicol (2008) 3.48

Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol (2000) 3.46

Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia. Ann Emerg Med (2008) 3.44

Community-acquired pneumonia. Lancet (1998) 3.21

Choline and human nutrition. Annu Rev Nutr (1994) 3.09

Community-acquired pneumonia. Lancet (2003) 2.80

Procalcitonin increase in early identification of critically ill patients at high risk of mortality. Crit Care Med (2006) 2.77

Bioactive sphingolipids: metabolism and function. J Lipid Res (2008) 2.73

Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comp Funct Genomics (2001) 2.68

Metabolomics in systems biology. Annu Rev Plant Biol (2003) 2.65

Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis. J Am Coll Cardiol (2014) 2.48

Sex steroids and all-cause and cause-specific mortality in men. Arch Intern Med (2007) 2.27

The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia. Diabetes Care (2005) 2.24

Glutathione deficiency is associated with impaired survival in HIV disease. Proc Natl Acad Sci U S A (1997) 2.20

Plasma sphingomyelin level as a risk factor for coronary artery disease. Arterioscler Thromb Vasc Biol (2000) 2.16

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem (1993) 2.13

Epidemiology of community-acquired pneumonia in adults: a population-based study. Eur Respir J (2000) 2.09

Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation (2009) 2.05

Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res (2014) 2.02

Risk factors of treatment failure in community acquired pneumonia: implications for disease outcome. Thorax (2004) 1.93

Prognostic value of procalcitonin in community-acquired pneumonia. Eur Respir J (2010) 1.83

Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3. Biochem Pharmacol (1998) 1.80

The exogenous origin of trimethylamine in the mouse. Metabolism (1992) 1.78

Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis. Crit Care Med (2001) 1.68

Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients. J Lipid Res (2003) 1.67

Glutamine and glutathione at ICU admission in relation to outcome. Clin Sci (Lond) (2012) 1.65

Oxidative stress and gene expression in sepsis. Br J Anaesth (2003) 1.64

Carnitine: a nutritional, biosynthetic, and functional perspective. Mol Aspects Med (2004) 1.64

The role of asymmetric and symmetric dimethylarginines in renal disease. Nat Rev Nephrol (2011) 1.58

Inflammatory responses predict long-term mortality risk in community-acquired pneumonia. Eur Respir J (2010) 1.57

Environmental toxicity, redox signaling and lung inflammation: the role of glutathione. Mol Aspects Med (2008) 1.56

Biomarker-enhanced triage in respiratory infections: a proof-of-concept feasibility trial. Eur Respir J (2013) 1.51

Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration. Eur J Clin Pharmacol (1989) 1.50

Cohort Profile: The Health In Men Study (HIMS). Int J Epidemiol (2008) 1.47

Adrenomedullin refines mortality prediction by the BODE index in COPD: the "BODE-A" index. Eur Respir J (2013) 1.45

The effect of diurnal variation on clinical measurement of serum testosterone and other sex hormone levels in men. J Clin Endocrinol Metab (2008) 1.37

Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes. Eur Respir J (2007) 1.34

Clinical review 95: Acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab (1998) 1.30

Asymmetric dimethylarginine is increased in asthma. Am J Respir Crit Care Med (2011) 1.25

Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure. J Card Fail (2014) 1.24

Non-classical actions of testosterone: an update. Trends Endocrinol Metab (2007) 1.22

Further evaluation of plasma sphingomyelin levels as a risk factor for coronary artery disease. Nutr Metab (Lond) (2006) 1.20

Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study. BMJ (2012) 1.20

Application of 'omics technologies to biomarker discovery in inflammatory lung diseases. Eur Respir J (2013) 1.19

High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients. Shock (2010) 1.19

Human betaine-homocysteine methyltransferase is a zinc metalloenzyme. Arch Biochem Biophys (1998) 1.18

Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. Crit Care (2010) 1.17

Gender differences in cytokine secretion by human peripheral blood mononuclear cells: role of estrogen in modulating LPS-induced cytokine secretion in an ex vivo septic model. Shock (2001) 1.16

Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumonia. Am J Respir Crit Care Med (2007) 1.15

A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients. J Am Heart Assoc (2013) 1.15

Biomarker-guided de-escalation of empirical therapy is associated with lower risk for adverse outcomes. Intensive Care Med (2013) 1.11

Methionine metabolism in mammals: kinetic study of betaine-homocysteine methyltransferase. Arch Biochem Biophys (1972) 1.11

Basic concepts and recent developments in human steroid hormone biosynthesis. Rev Endocr Metab Disord (2007) 1.10

The hypothalamic-pituitary-adrenal response to critical illness. Best Pract Res Clin Endocrinol Metab (2001) 1.08

Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One (2014) 1.08

Metabolomics study on the hepatoprotective effect of scoparone using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. Analyst (2012) 1.07

Long-term prognosis in community-acquired pneumonia. Curr Opin Infect Dis (2013) 1.06

Progesterone and autoimmune disease. Autoimmun Rev (2011) 1.05

Symmetrical dimethylarginine predicts mortality in the general population: observations from the Dallas heart study. Arterioscler Thromb Vasc Biol (2013) 1.03

17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood (2004) 1.03

Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock. J Clin Endocrinol Metab (2006) 1.01

Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study. Clin Res Cardiol (2012) 1.00

Elderly Nutrition and Health Survey in Taiwan (1999-2000): research design, methodology and content. Asia Pac J Clin Nutr (2005) 1.00

Optimizing triage and hospitalization in adult general medical emergency patients: the triage project. BMC Emerg Med (2013) 1.00

Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis. Endothelium (2007) 0.99

Blood biomarkers for personalized treatment and patient management decisions in community-acquired pneumonia. Curr Opin Infect Dis (2013) 0.98

An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function. PLoS One (2011) 0.97

Exploration of serum metabolomic profiles and outcomes in women with metastatic breast cancer: a pilot study. Mol Oncol (2012) 0.92

Oxidative signaling and glutathione synthesis. Biofactors (2003) 0.91

Glycerophospholipid and sphingolipid species and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. PLoS One (2014) 0.91

Biomarker-guided personalised emergency medicine for all - hope for another hype? Swiss Med Wkly (2015) 0.90

Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study. BMC Infect Dis (2012) 0.89

Adrenal response in severe community-acquired pneumonia: impact on outcomes and disease severity. Chest (2008) 0.89

Predictors for length of hospital stay in patients with community-acquired pneumonia: results from a Swiss multicenter study. BMC Pulm Med (2012) 0.87

Endocrine changes in critical illness. J Intensive Care Med (2004) 0.86

Low serum levels of dehydroepiandrosterone sulfate predict all-cause and cardiovascular mortality in elderly Swedish men. J Clin Endocrinol Metab (2010) 0.86

C-reactive protein and homocysteine predict long-term mortality in young ischemic stroke patients. J Stroke Cerebrovasc Dis (2013) 0.86

Vitamin B12, folic acid, and bone. Curr Osteoporos Rep (2013) 0.86

Adrenal function is related to prognosis in moderate community-acquired pneumonia. Eur Respir J (2010) 0.86

Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia. J Infect (2011) 0.85

The prognostic blood biomarker proadrenomedullin for outcome prediction in patients with chronic obstructive pulmonary disease (COPD): a qualitative clinical review. Clin Chem Lab Med (2015) 0.85

Homocysteine concentration and the risk of death in the adult Polish population. Kardiol Pol (2012) 0.85

Prognostic value of procalcitonin in Legionella pneumonia. Eur J Clin Microbiol Infect Dis (2008) 0.85

Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis. Mediators Inflamm (2013) 0.85