The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations.

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Published in J Prev Alzheimers Dis on December 01, 2014

Authors

E Cavedo1, S Lista2, Z Khachaturian3, P Aisen4, P Amouyel5, K Herholz6, C R Jack7, R Sperling8, J Cummings9, K Blennow10, S O'Bryant11, G B Frisoni12, A Khachaturian13, M Kivipelto14, W Klunk15, K Broich16, S Andrieu17, M Thiebaut de Schotten18, J-F Mangin19, A A Lammertsma20, K Johnson21, S Teipel22, A Drzezga23, A Bokde24, O Colliot25, H Bakardjian26, H Zetterberg27, B Dubois28, B Vellas29, L S Schneider30, H Hampel2

Author Affiliations

1: Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) Hôpital de la Pitié-Salpétrière & Institut du Cerveau et de la Moelle épinière (ICM), UMR S 1127, Hôpital de la Pitié-Salpétrière Paris & CATI multicenter neuroimaging platform, France; Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio Fatebenefratelli Brescia, Italy.
2: AXA Research Fund & UPMC Chair; Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) Hôpital de la Pitié-Salpétrière & Inserm U1127 Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpétrière Paris, France.
3: The Campaign to Prevent Alzheimer's Disease by 2020 (PAD2020), Potomac, MD, USA.
4: Department of Neurosciences, University of California San Diego, San Diego, CA, USA.
5: Inserm, U744, Lille, 59000, France; Université Lille 2, Lille, 59000, France; Institut Pasteur de Lille, Lille, 59000, France; Centre Hospitalier Régional Universitaire de Lille, Lille, 59000, France.
6: Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.
7: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
8: Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
9: Cleveland Clinic Lou Ruvo Center for Brain Health, 888 West Bonneville Avenue, Las Vegas, Nevada 89106, USA.
10: Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
11: Department of Internal Medicine, Institute for Aging & Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA.
12: IRCCS Istituto Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy; University Hospitals and University of Geneva, Geneva, Switzerland.
13: Executive Editor, Alzheimer's & Dementia.
14: Karolinska Institutet Alzheimer Research Center, NVS, Stockholm, Sweden.
15: Department of Psychiatry, University of Pittsburgh School of Medicine, USA; Department of Neurology, University of Pittsburgh School of Medicine, USA.
16: Federal Institute of Drugs and Medical Devices (BfArM), Bonn, Germany.
17: Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France; Public health department, CHU de Toulouse.
18: Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, London, UK; Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (ICM), UMRS 1127 Paris, France; Inserm, U 1127, Paris, France; CNRS, UMR 7225, Paris, France.
19: CEA UNATI, Neurospin, CEA Gif-sur-Yvette, France & CATI multicenter neuroimaging platform.
20: Department of Radiology & Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
21: Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
22: Department of Psychosomatic Medicine, University of Rostock, and DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany.
23: Department of Nuclear Medicine, University Hospital of Cologne, Cologne Germany.
24: Cognitive Systems Group, Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
25: Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, Inserm, U1127, F-75013, Paris, France; CNRS, UMR 7225 ICM, 75013, Paris, France; Inria, Aramis project-team, Centre de Recherche Paris-Rocquencourt, France.
26: Institute of Memory and Alzheimer's Disease (IM2A), Pitié-Salpétrière University Hospital, Paris, France; IHU-A-ICM - Paris Institute of Translational Neurosciences, Paris, France.
27: Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology, Queen Square, London, UK.
28: Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) Hôpital de la Pitié-Salpétrière & Inserm U1127 Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié-Salpétrière Paris, France.
29: Inserm UMR1027, University of Toulouse, Toulouse, France.
30: Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Associated clinical trials:

Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier) | NCT00574132

Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Carrier) | NCT00575055

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. (DIAN-TU) | NCT01760005

A Study of Crenezumab Versus Placebo in Preclinical PSEN1 E280A Mutation Carriers to Evaluate Efficacy and Safety in the Treatment of Autosomal-Dominant Alzheimer Disease (AD), Including a Placebo-Treated Noncarrier Cohort | NCT01998841

A Multicenter, Double Blind, Placebo-Controlled, Safety and Tolerability Study of BMS-708163 in Patients With Prodromal Alzheimer's Disease | NCT00890890

A Study of Gantenerumab in Participants With Prodromal Alzheimer's Disease | NCT01224106

Efficacy and Safety Trial of Verubecestat (MK-8931) in Participants With Prodromal Alzheimer's Disease (MK-8931-019) (APECS) | NCT01953601

Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss (A4) | NCT02008357

Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset (TOMMORROW) | NCT01931566

Omega-3 Fatty Acids and/or Multi-domain Intervention in the Prevention of Age-related Cognitive Decline (MAPT) | NCT00672685

Metformin in Amnestic Mild Cognitive Impairment (MCI) | NCT00620191

Multiple Dose Study of Aducanumab (BIIB037) (Recombinant, Fully Human Anti-Aβ IgG1 mAb) in Participants With Prodromal or Mild Alzheimer's Disease | NCT01677572

SNIFF 120: Study of Nasal Insulin to Fight Forgetfulness (120 Days) (SNIFF 120) | NCT00438568

A Study to Evaluate Safety, Tolerability, and Efficacy of BAN2401 in Subjects With Early Alzheimer's Disease | NCT01767311

Disease-modifying Properties of Lithium in the Neurobiology of Alzheimer's Disease | NCT01055392

Memory Impairment Study (Mild Cognitive Impairment Study) | NCT00000173

Investigation Into Delay to Diagnosis of Alzheimer's Disease With Exelon (InDDEx) | NCT00000174

Evaluation of E2609 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (Study: E2609-A001-101 Amendment 02) | NCT01600859

Study of LY2886721 in Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease | NCT01561430

Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease | NCT01811381

Study of the Pharmacokinetics and Pharmacodynamics of POSIPHEN® in Subjects With Amnestic Mild Cognitive Impairment | NCT01072812

Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120) (SL120) | NCT01595646

A Study to Evaluate the Efficacy and Safety of Galantamine in Patients With Mild Cognitive Impairment | NCT00236574

Effects of Simvastatin on Biomarkers (SimBio) | NCT01142336

Study of the Effects of Cerefolin NAC on Inflammation Blood Markers in Older Individuals With Memory Complaints | NCT00597376

Brain Imaging and Mental Disorders of Aging Intervention | NCT00267163

Evaluation of a Computerized Complex Instrumental Activities of Daily Living Marker (Altoida™) (AltoidaML) | NCT02843529

Pre-Clinical (Alzheimers) Diagnosis PCD = Optimum Outcomes OO (PCD=OOALZ) | NCT02835716

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