Published in Nat Genet on January 01, 2007
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet (2009) 14.86
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GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron (2007) 6.88
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A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. Cell (2008) 2.55
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Replication of CLU, CR1, and PICALM associations with alzheimer disease. Arch Neurol (2010) 2.02
Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 2.01
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Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease. Neuroimage (2010) 1.94
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Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. Eur J Hum Genet (2010) 1.79
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Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci (2011) 1.74
Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses. CMAJ (2009) 1.73
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The impact of multifunctional genes on "guilt by association" analysis. PLoS One (2011) 1.69
Identifying quantitative trait loci via group-sparse multitask regression and feature selection: an imaging genetics study of the ADNI cohort. Bioinformatics (2011) 1.69
Genetic and environmental pathways to complex diseases. BMC Syst Biol (2009) 1.67
On Jim Watson's APOE status: genetic information is hard to hide. Eur J Hum Genet (2008) 1.67
The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease. Alzheimers Dement (2015) 1.66
Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells. Cell Stem Cell (2015) 1.61
Systematic reviews of genetic association studies. Human Genome Epidemiology Network. PLoS Med (2009) 1.60
MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders. Curr Genomics (2009) 1.60
AutismKB: an evidence-based knowledgebase of autism genetics. Nucleic Acids Res (2011) 1.59
SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease. PLoS Genet (2010) 1.58
A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. Am J Hum Genet (2007) 1.55
The application of naive Bayes model averaging to predict Alzheimer's disease from genome-wide data. J Am Med Inform Assoc (2011) 1.52
Genotype-phenotype databases: challenges and solutions for the post-genomic era. Nat Rev Genet (2009) 1.52
Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease neuroimaging initiative (ADNI) plasma proteome dataset. PLoS One (2012) 1.51
Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Gut (2013) 1.51
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Mol Psychiatry (2009) 1.51
Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease. Neurogenetics (2009) 1.50
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron (2008) 1.49
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet (2009) 1.46
Proteolytic degradation of amyloid β-protein. Cold Spring Harb Perspect Med (2012) 1.46
Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Neurogenetics (2008) 1.46
Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci. Arch Neurol (2008) 1.44
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Effect of APOE and CD33 on Cognitive Decline. PLoS One (2015) 1.43
Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer's disease. Neuroimage (2011) 1.41
Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. J Neuroinflammation (2011) 1.41
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model. J Immunol (2011) 1.36
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Genome-wide scan of copy number variation in late-onset Alzheimer's disease. J Alzheimers Dis (2010) 1.35
Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Am J Med Genet B Neuropsychiatr Genet (2008) 1.35
The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Hum Mol Genet (2009) 1.35
Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration. J Alzheimers Dis (2010) 1.34
MicroRNAs can regulate human APP levels. Mol Neurodegener (2008) 1.34
A systematic meta-analysis of genetic association studies for diabetic retinopathy. Diabetes (2009) 1.33
An update on cancer- and chemotherapy-related cognitive dysfunction: current status. Semin Oncol (2011) 1.32
Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study. BMC Neurol (2010) 1.32
Target identification for CNS diseases by transcriptional profiling. Neuropsychopharmacology (2008) 1.32
Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.32
No association between CALHM1 and Alzheimer's disease risk. Cell (2008) 1.30
Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophr Res (2008) 1.29
Genetic aspects of Alzheimer disease. Genet Med (2008) 1.26
Evaluating historical candidate genes for schizophrenia. Mol Psychiatry (2015) 1.26
Connectomic intermediate phenotypes for psychiatric disorders. Front Psychiatry (2012) 1.26
The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE. Neurobiol Aging (2010) 1.25
Genotator: a disease-agnostic tool for genetic annotation of disease. BMC Med Genomics (2010) 1.24
Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. J Alzheimers Dis (2010) 1.24
Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics (2008) 1.23
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers. Brain Imaging Behav (2014) 1.23
Genomic convergence to identify candidate genes for Alzheimer disease on chromosome 10. Hum Mutat (2009) 1.21
PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression. Cell Metab (2009) 1.21
Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy. Alzheimers Res Ther (2010) 1.20
Current status on Alzheimer disease molecular genetics: from past, to present, to future. Hum Mol Genet (2010) 1.20
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage (2006) 25.52
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet (2008) 6.71
Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med (2012) 6.27
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A (2003) 5.44
The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex (2008) 5.36
The genetics of Alzheimer disease: back to the future. Neuron (2010) 4.91
Medial temporal lobe function and structure in mild cognitive impairment. Ann Neurol (2004) 4.89
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet (2008) 4.66
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci (2008) 4.64
Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med (2005) 4.34
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27
Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. J Neurosci (2006) 4.14
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron (2007) 3.98
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol (2003) 3.58
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron (2013) 3.43
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet (2005) 3.24
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am J Pathol (2004) 3.24
Delusions and hallucinations are associated with worse outcome in Alzheimer disease. Arch Neurol (2005) 3.10
Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum Mol Genet (2003) 3.00
Alzheimer's disease: the cholesterol connection. Nat Neurosci (2003) 2.99
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol (2010) 2.91
The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS One (2010) 2.78
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (2011) 2.66
The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol (2008) 2.54
Psychiatric genetics: a survey of psychiatrists' knowledge, opinions, and practice patterns. J Clin Psychiatry (2005) 2.46
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell (2010) 2.46
Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet (2007) 2.45
The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci (2007) 2.42
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron (2008) 2.30
The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology (2006) 2.26
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron (2010) 2.20
The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. Biol Psychiatry (2007) 2.19
Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging. Stroke (2008) 2.12
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
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The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis. Epidemiology (2011) 2.01
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem (2002) 2.00
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Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet (2003) 1.91
The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg (2011) 1.88
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Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci (2006) 1.83
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The synaptic Abeta hypothesis of Alzheimer disease. Nat Neurosci (2005) 1.68
The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β. Neurobiol Aging (2010) 1.62
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Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci (2010) 1.58
Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics (2008) 1.58
The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco. Hum Mol Genet (2007) 1.57
PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis (2010) 1.57
The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol (2009) 1.56
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BACE is degraded via the lysosomal pathway. J Biol Chem (2005) 1.53
Longitudinal change in cognitive performance among individuals with mild cognitive impairment. Neuropsychology (2007) 1.49
Alzheimer's disease: one disorder, too many genes? Hum Mol Genet (2004) 1.48
Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer disease. Arch Neurol (2008) 1.48
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet (2009) 1.46
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Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci (2008) 1.44
Family-based association test for time-to-onset data with time-dependent differences between the hazard functions. Genet Epidemiol (2006) 1.43
Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample. Neuropsychopharmacology (2008) 1.42
Alzheimer's disease and post-operative cognitive dysfunction. Exp Gerontol (2006) 1.41
Disruptive behavior as a predictor in Alzheimer disease. Arch Neurol (2007) 1.39
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A new multimarker test for family-based association studies. Genet Epidemiol (2007) 1.34
Seizures in Alzheimer disease: who, when, and how common? Arch Neurol (2009) 1.34
The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem (2008) 1.31
No association between CALHM1 and Alzheimer's disease risk. Cell (2008) 1.30
The role of peripheral inflammatory markers in dementia and Alzheimer's disease: a meta-analysis. J Gerontol A Biol Sci Med Sci (2012) 1.29
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Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP). J Biol Chem (2003) 1.26
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem (2006) 1.26
ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function. Neuron (2013) 1.25