Andrographolide Ameliorates Abdominal Aortic Aneurysm Progression by Inhibiting Inflammatory Cell Infiltration through Downregulation of Cytokine and Integrin Expression.

Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model. Sci Rep (2017) 0.75

Andrographolide inhibits arrhythmias and is cardioprotective in rabbits. Oncotarget (2017) 0.75

Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (2014) 26.76

Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest (2000) 4.90

Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. J Clin Invest (2002) 4.79

The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol (2009) 4.61

Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol (2006) 3.01

Mouse models of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol (2004) 2.94

Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation. Circulation (2005) 2.67

Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. J Clin Invest (1995) 2.53

Pathophysiology and epidemiology of abdominal aortic aneurysms. Nat Rev Cardiol (2010) 2.11

Surgery for small asymptomatic abdominal aortic aneurysms. Cochrane Database Syst Rev (2012) 1.81

Isolation and characterization of murine retinal endothelial cells. Mol Vis (2003) 1.80

Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds. Ann N Y Acad Sci (2006) 1.80

Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. Mol Biol Cell (2007) 1.72

Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation. Cardiovasc Res (2012) 1.61

Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. J Immunol (2004) 1.58

Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med (2004) 1.55

Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Indian J Med Res (1990) 1.49

Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation. Stroke (2009) 1.45

Epidemiology of aortic aneurysm repair in the United States from 2000 to 2010. J Vasc Surg (2014) 1.44

NF-kappaB is a key mediator of cerebral aneurysm formation. Circulation (2007) 1.39

TNF-alpha-mediated inflammation in cerebral aneurysms: a potential link to growth and rupture. Vasc Health Risk Manag (2008) 1.31

Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB. PLoS One (2013) 1.18

Reactive oxygen species induce apoptosis of vascular smooth muscle cell. FEBS Lett (1997) 1.17

Clinical practice. Abdominal aortic aneurysms. N Engl J Med (2014) 1.15

Andrographolide up-regulates cellular-reduced glutathione level and protects cardiomyocytes against hypoxia/reoxygenation injury. J Pharmacol Exp Ther (2008) 1.13

Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation. J Thorac Cardiovasc Surg (2011) 1.11

Deletion of CCR2 but not CCR5 or CXCR3 inhibits aortic aneurysm formation. Surgery (2007) 1.08

Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model. Circ Res (2007) 1.08

Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context? J Clin Invest (2004) 1.05

Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells. J Biol Chem (2010) 1.03

Surveillance intervals for small abdominal aortic aneurysms: a meta-analysis. JAMA (2013) 1.01

Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta Med (2003) 1.01

Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide. Evid Based Complement Alternat Med (2013) 1.00

Protein kinase C-delta mediates adventitial cell migration through regulation of monocyte chemoattractant protein-1 expression in a rat angioplasty model. Arterioscler Thromb Vasc Biol (2012) 1.00

Kinetics of cellular proliferation after arterial injury. V. Role of acute distension in the induction of smooth muscle proliferation. Lab Invest (1989) 0.99

Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade. Biochem Pharmacol (2012) 0.98

Prevention of abdominal aortic aneurysms by simultaneous inhibition of NFkappaB and ets using chimeric decoy oligonucleotides in a rabbit model. Gene Ther (2006) 0.97

Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors. Circulation (2003) 0.96

Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol (2009) 0.95

Thrombospondin-1 (TSP1) contributes to the development of vascular inflammation by regulating monocytic cell motility in mouse models of abdominal aortic aneurysm. Circ Res (2015) 0.95

Andrographolide inhibits NF-kappaBeta activation and attenuates neointimal hyperplasia in arterial restenosis. Cell Res (2007) 0.91

Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm. PLoS One (2014) 0.89

Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells. Biochem Pharmacol (2014) 0.87

Protein kinase C-δ (PKCδ) regulates proinflammatory chemokine expression through cytosolic interaction with the NF-κB subunit p65 in vascular smooth muscle cells. J Biol Chem (2014) 0.85

Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation. Circ Res (2015) 0.84

Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression. Anticancer Res (2007) 0.83

TRIF adaptor signaling is important in abdominal aortic aneurysm formation. Atherosclerosis (2015) 0.81

Murine abdominal aortic aneurysm model by orthotopic allograft transplantation of elastase-treated abdominal aorta. J Vasc Surg (2014) 0.81

Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42. Mol Biol Cell (2012) 0.80