Published in PLoS One on October 20, 2015
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol (1996) 22.30
Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem (1993) 10.95
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med (2010) 4.61
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res (2002) 3.75
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest (2012) 2.98
Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell (1989) 2.14
Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Mol Pharmacol (2007) 1.97
Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier. Mol Pharmacol (2006) 1.76
HMGB1 in health and disease. Mol Aspects Med (2014) 1.67
A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta. Brain (2008) 1.64
Cellular signalling of the receptor for advanced glycation end products (RAGE). Cell Signal (2013) 1.48
Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance. J Neurosci (2002) 1.44
Development of new antiepileptic drugs: challenges, incentives, and recent advances. Lancet Neurol (2007) 1.44
Important aspects of Toll-like receptors, ligands and their signaling pathways. Inflamm Res (2010) 1.40
Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies. Brain Res (2003) 1.28
Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy. Epilepsia (2004) 1.17
The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases. Mol Med (2014) 1.17
Modulating P-glycoprotein regulation: future perspectives for pharmacoresistant epilepsies? Epilepsia (2010) 1.14
Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation. J Neurochem (2007) 1.10
Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables. J Histochem Cytochem (2005) 1.07
Statins attenuate high mobility group box-1 protein induced vascular endothelial activation : a key role for TLR4/NF-κB signaling pathway. Mol Cell Biochem (2010) 1.06
Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1. J Intern Med (2011) 1.06
Potential role of multidrug resistant proteins in refractory epilepsy and antiepileptic drugs interactions. Drug Metabol Drug Interact (2011) 1.02
HIV-Tat protein induces P-glycoprotein expression in brain microvascular endothelial cells. J Neurochem (2005) 0.99
Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma. Exp Hematol (2011) 0.98
Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience (2004) 0.97
Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. Epilepsy Res (2010) 0.97
Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia. Cell Physiol Biochem (2008) 0.96
Epilepsy and inflammation in the brain: overview and pathophysiology. Epilepsy Curr (2014) 0.94
Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy? Epilepsy Curr (2012) 0.94
Glutathione prevents free fatty acids-induced oxidative stress and apoptosis in human brain vascular endothelial cells through Akt pathway. CNS Neurosci Ther (2013) 0.91
Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures. Neurobiol Dis (2013) 0.90
Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy. Epilepsy Res (2002) 0.88
Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections. Exp Brain Res (1999) 0.87
Lipopolysaccharide appears to activate human endometrial endothelial cells through TLR-4-dependent and TLR-4-independent mechanisms. Am J Reprod Immunol (2012) 0.86
Nuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats. Mediators Inflamm (2011) 0.86
From willow bark to peptides: the ever widening spectrum of NF-kappaB inhibitors. Curr Opin Pharmacol (2006) 0.83
Modifications in astrocyte morphology and calcium signaling induced by a brain capillary endothelial cell line. Glia (2002) 0.82
Signaling to P-glycoprotein-A new therapeutic target to treat drug-resistant epilepsy? Drug News Perspect (2009) 0.81
Extracellular high mobility group box chromosomal protein 1 promotes drug resistance by increasing the expression of P‑glycoprotein expression in gastric adenocarcinoma cells. Mol Med Rep (2014) 0.80
Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha. J Biomed Biotechnol (2010) 0.80
Effects of brain IKKβ gene silencing by small interfering RNA on P-glycoprotein expression and brain damage in the rat kainic acid-induced seizure model. CNS Neurol Disord Drug Targets (2014) 0.77