Published in Cell on June 16, 1989
Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol (1992) 12.96
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol (1992) 5.04
Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO J (2004) 3.17
The akt kinase: molecular determinants of oncogenicity. Proc Natl Acad Sci U S A (1998) 2.99
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A (1997) 2.88
VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J (2002) 2.05
Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors. Proc Natl Acad Sci U S A (1994) 1.78
VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J Exp Med (2008) 1.78
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest (2009) 1.68
Lessons in signaling and tumorigenesis from polyomavirus middle T antigen. Microbiol Mol Biol Rev (2009) 1.48
NHERF-2 maintains endothelial homeostasis. Blood (2012) 1.47
SPARC is a source of copper-binding peptides that stimulate angiogenesis. J Cell Biol (1994) 1.40
Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis. Proc Natl Acad Sci U S A (1995) 1.33
CXC chemokines, MIP-2 and KC, induce P-selectin-dependent neutrophil rolling and extravascular migration in vivo. Br J Pharmacol (2001) 1.24
Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity. Proc Natl Acad Sci U S A (1990) 1.24
Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology (2008) 1.20
Thrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis. Mol Biol Cell (1997) 1.06
Down-regulation of platelet endothelial cell adhesion molecule-1 results in thrombospondin-1 expression and concerted regulation of endothelial cell phenotype. Mol Biol Cell (1998) 1.03
Natural biology of polyomavirus middle T antigen. Microbiol Mol Biol Rev (2001) 1.02
GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression. J Biol Chem (2009) 1.01
Angiopoietin-2 is critical for cytokine-induced vascular leakage. PLoS One (2013) 0.99
Pathogenesis of hemangioma. J Clin Invest (2001) 0.99
EA-1, a novel adhesion molecule involved in the homing of progenitor T lymphocytes to the thymus. J Cell Biol (1991) 0.99
CC chemokines induce P-selectin-dependent neutrophil rolling and recruitment in vivo: intermediary role of mast cells. Br J Pharmacol (2003) 0.97
Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1. Histochem Cell Biol (2008) 0.96
In vitro degradation of endothelial catenins by a neutrophil protease. J Cell Biol (1998) 0.94
Evidence that the middle T antigen of polyomavirus interacts with the membrane skeleton. Mol Cell Biol (1993) 0.91
Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase. J Exp Med (1995) 0.85
Envelope glycoprotein of avian hemangioma retrovirus induces a thrombogenic surface on human and bovine endothelial cells. J Virol (1990) 0.84
The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner. Oncogene (2014) 0.84
A statin-based inhibitor of lymphocyte function antigen-1 protects against ischemia/reperfusion-induced leukocyte adhesion in the colon. Br J Pharmacol (2003) 0.84
Mast cell-derived tumour necrosis factor-alpha mediates macrophage inflammatory protein-2-induced recruitment of neutrophils in mice. Br J Pharmacol (2005) 0.84
Glutamate-stimulated peroxynitrite production in a brain-derived endothelial cell line is dependent on N-methyl-D-aspartate (NMDA) receptor activation. Biochem Pharmacol (2006) 0.83
Development of immortalized mouse aortic endothelial cell lines. Vasc Cell (2014) 0.83
EMBO medal review. On transferring genes into stem cells and mice. EMBO J (1990) 0.83
Disruption and inactivation of the PP2A complex promotes the proliferation and angiogenesis of hemangioma endothelial cells through activating AKT and ERK. Oncotarget (2015) 0.80
Application of angiogenesis to clinical dermatology. Adv Dermatol (2008) 0.79
Generation of recombinant murine retroviral genomes containing the v-src oncogene: isolation of a virus inducing hemangiosarcomas in the brain. J Virol (1991) 0.79
Glucocorticoids Suppress Mitochondrial Oxidant Production via Upregulation of Uncoupling Protein 2 in Hyperglycemic Endothelial Cells. PLoS One (2016) 0.77
Endogenously produced nitric oxide inhibits endothelial cell growth as demonstrated using novel antisense cell lines. Br J Pharmacol (2000) 0.77
HMGB1 Contributes to the Expression of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products. PLoS One (2015) 0.77
Expression pattern of protein kinase C ϵ during mouse embryogenesis. BMC Dev Biol (2013) 0.77
Decreased adhesion to endothelial cells and matrix proteins of H-2Kb gene transfected tumour cells. Br J Cancer (1993) 0.77
Endothelial basement membrane laminin 511 is essential for shear stress response. EMBO J (2016) 0.75
Intimal cushions and endothelial nuclear elongation around mouse aortic branches and their spatial correspondence with patterns of lipid deposition. Am J Physiol Heart Circ Physiol (2009) 0.75
Novel characterization of bEnd.3 cells that express lymphatic vessel endothelial hyaluronan receptor-1. Lymphology (2014) 0.75
The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro. Pharmacol Res (2016) 0.75
Grafting mouse brains: from neurocarcinogenesis to neurodegeneration. EMBO J (1998) 0.75
Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction. JCI Insight (2017) 0.75
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (1996) 18.47
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature (1988) 13.21
Mice devoid of PrP are resistant to scrapie. Cell (1993) 11.46
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature (1992) 10.10
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature (1995) 8.12
Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Nature (1985) 7.54
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell (1993) 7.14
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J (1996) 6.66
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature (1995) 6.13
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science (1994) 5.97
Strain-dependent epithelial defects in mice lacking the EGF receptor. Science (1995) 5.22
Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature (1994) 5.19
Imprinted expression of the Igf2r gene depends on an intronic CpG island. Nature (1997) 5.08
The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat Genet (1999) 4.77
Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev (1999) 4.75
Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development (1992) 4.69
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev (1995) 4.54
Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc Natl Acad Sci U S A (1997) 4.52
Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature (1996) 4.25
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res (1999) 4.23
Bone and haematopoietic defects in mice lacking c-fos. Nature (1993) 4.07
AP-1 in mouse development and tumorigenesis. Oncogene (2001) 3.93
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell (1994) 3.91
Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Proc Natl Acad Sci U S A (1987) 3.88
Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci (1998) 3.80
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature (1989) 3.80
Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem (1995) 3.69
Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. Proc Natl Acad Sci U S A (1986) 3.68
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell (1998) 3.59
The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem (1996) 3.53
Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev (1999) 3.51
c-jun is essential for normal mouse development and hepatogenesis. Nature (1993) 3.43
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet (1999) 3.42
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev (1995) 3.41
Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. Eur J Cell Biol (1994) 3.31
Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev Biol (1999) 3.29
PARP is important for genomic stability but dispensable in apoptosis. Genes Dev (1997) 3.20
A crucial role for B cells in neuroinvasive scrapie. Nature (1998) 3.19
The human beta-globin gene and a functional viral thymidine kinase gene in developing mice. Proc Natl Acad Sci U S A (1981) 2.93
Measles virus spread and pathogenesis in genetically modified mice. J Virol (1998) 2.84
Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium. Circ Res (1994) 2.82
SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo. Transplantation (1997) 2.80
Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell (1990) 2.77
Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev (1992) 2.77
Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. Blood (1996) 2.76
Vascular endothelial growth factor induces endothelial fenestrations in vitro. J Cell Biol (1998) 2.71
Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability. Circulation (2000) 2.71
Cigarette smoking, major depression, and other psychiatric disorders among adolescents. J Am Acad Child Adolesc Psychiatry (1996) 2.69
Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation (1991) 2.61
Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol (2000) 2.61
Transfer of genes into embryonal carcinoma cells by retrovirus infection: efficient expression from an internal promoter. EMBO J (1985) 2.60
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr Biol (1999) 2.60
Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo. Cancer Res (1996) 2.58
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev (1999) 2.56
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci (2000) 2.54
Role of tissue factor in embryonic blood vessel development. Nature (1996) 2.54
A matrix-less measles virus is infectious and elicits extensive cell fusion: consequences for propagation in the brain. EMBO J (1998) 2.48
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels. Mech Dev (1997) 2.47
Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development (2000) 2.43
PrP expression in B lymphocytes is not required for prion neuroinvasion. Nat Med (1998) 2.40
Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res (1993) 2.39
Physical training improves endothelial function in patients with chronic heart failure. Circulation (1996) 2.38
Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat Med (2000) 2.36
Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene. Cell (1988) 2.36
Differentiation of F9 teratocarcinoma stem cells after transfer of c-fos proto-oncogenes. Nature (1984) 2.34
Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. Am J Pathol (1998) 2.34
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J (2001) 2.32
Flk-1 expression defines a population of early embryonic hematopoietic precursors. Development (1997) 2.32
Complement facilitates early prion pathogenesis. Nat Med (2001) 2.30
Molecular mechanisms of vasculogenesis and embryonic angiogenesis. J Cell Physiol (1997) 2.27
Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer (1994) 2.24
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc Natl Acad Sci U S A (1994) 2.24
Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res (1995) 2.23
The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell (2000) 2.22
New variant of Creutzfeldt-Jakob disease in a 26-year-old French man. Lancet (1996) 2.20
Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A (1995) 2.19
Angiopoietin-1 induces sprouting angiogenesis in vitro. Curr Biol (1998) 2.18
High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene. Mol Med (1994) 2.18
Role of NAD(P)H oxidase in angiotensin II-induced JAK/STAT signaling and cytokine induction. Circ Res (2000) 2.16
Expression of retroviral vectors in transgenic mice obtained by embryo infection. EMBO J (1987) 2.16
Post-exposure prophylaxis after accidental prion inoculation. Lancet (1997) 2.15
Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science (2000) 2.15
Prion research: the next frontiers. Nature (1997) 2.13
Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice. Neuron (2000) 2.13
Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies. Development (1988) 2.12
Analysis of the differentiation-promoting potential of inducible c-fos genes introduced into embryonal carcinoma cells. EMBO J (1985) 2.11
A universal retroviral vector for efficient constitutive expression of exogenous genes. Nucleic Acids Res (1987) 2.11
Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol (1995) 2.10
The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res (1996) 2.09
Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature (1987) 2.08
PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature (1997) 2.08
The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med (1997) 2.07
JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression. EMBO J (2000) 2.05
Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure. Circ Res (1994) 2.04