Published in Oncotarget on December 08, 2015
Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification. Sci Rep (2016) 0.75
Targeting prohibitins induces apoptosis in acute myeloid leukemia cells. Oncotarget (2016) 0.75
The prohibitin protein complex promotes mitochondrial stabilization and cell survival in hematologic malignancies. Oncotarget (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell (2005) 13.59
Mitochondrial membrane permeabilization in cell death. Physiol Rev (2007) 12.72
p53 in health and disease. Nat Rev Mol Cell Biol (2007) 11.33
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science (2000) 8.74
Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol (2010) 7.95
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol (2014) 6.25
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem (2002) 5.61
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell (2002) 5.45
Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell (2011) 4.91
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1. EMBO J (2006) 4.39
Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem (1997) 3.41
Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J (2000) 3.08
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J (2011) 3.06
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes. Proc Natl Acad Sci U S A (2002) 3.01
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev (2008) 2.76
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J Cell Biol (2009) 2.65
The SPFH domain-containing proteins: more than lipid raft markers. Trends Cell Biol (2007) 2.49
MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin. Cancer Lett (2008) 2.48
Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. J Cell Biol (2009) 2.45
Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat Cell Biol (2005) 2.41
Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell (2008) 2.26
Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes. EMBO J (1994) 2.16
Noxa: at the tip of the balance between life and death. Oncogene (2008) 2.09
Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation. J Biol Chem (2005) 2.02
Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis. Biochim Biophys Acta (2008) 1.96
The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2. Chem Biol (2012) 1.82
Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways. Nucleic Acids Res (2003) 1.68
The mitochondrial prohibitin complex is essential for embryonic viability and germline function in Caenorhabditis elegans. J Biol Chem (2003) 1.67
Many players in BCL-2 family affairs. Trends Biochem Sci (2014) 1.64
Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. Nature (2009) 1.62
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Chem Biol (2011) 1.61
Prohibitin: a potential target for new therapeutics. Trends Mol Med (2005) 1.60
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J (2012) 1.58
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol (2008) 1.56
Prohibitin and mitochondrial biology. Trends Endocrinol Metab (2009) 1.54
Mitochondria: from cell death executioners to regulators of cell differentiation. Trends Cell Biol (2014) 1.53
Prohibitins and the functional compartmentalization of mitochondrial membranes. J Cell Sci (2009) 1.49
Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2. J Biol Chem (2006) 1.42
A repressive role for prohibitin in estrogen signaling. Mol Endocrinol (2007) 1.40
Prohibitin protects against oxidative stress in intestinal epithelial cells. FASEB J (2006) 1.39
Bim and Bmf in tissue homeostasis and malignant disease. Oncogene (2008) 1.36
Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo. Mol Cell Biol (2005) 1.36
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol (2014) 1.34
The role and therapeutic potential of prohibitin in disease. Biochim Biophys Acta (2011) 1.32
Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways. EMBO J (2006) 1.24
Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin. Biochem J (2004) 1.22
Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells. Cell Death Differ (2010) 1.21
The role of prohibitin in cell signaling. FEBS J (2010) 1.21
Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. Hepatology (2010) 1.19
Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics. EMBO J (2014) 1.15
Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis. Oncogene (2002) 1.15
Prohibitin ligands in cell death and survival: mode of action and therapeutic potential. Chem Biol (2013) 1.08
Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration. PLoS Genet (2012) 1.07
Mitochondrial-nuclear communication by prohibitin shuttling under oxidative stress. Biochemistry (2011) 1.04
Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein. Hepatology (2009) 1.03
Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function. Cell Death Differ (2014) 1.03
Prohibitins are required for cancer cell proliferation and adhesion. PLoS One (2010) 1.03
Prohibitin deficiency blocks proliferation and induces apoptosis in human hepatoma cells: molecular mechanisms and functional implications. Proteomics (2010) 1.01
Raf activation by Ras and promotion of cellular metastasis require phosphorylation of prohibitin in the raft domain of the plasma membrane. Oncogene (2012) 0.99
Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis. Proc Natl Acad Sci U S A (2014) 0.99
Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway. J Cell Physiol (2014) 0.92
Flavaglines as potent anticancer and cytoprotective agents. J Med Chem (2012) 0.92
Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development. Diabetes (2013) 0.89
Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med (2015) 0.89
Prohibitin (PHB) inhibits apoptosis in rat granulosa cells (GCs) through the extracellular signal-regulated kinase 1/2 (ERK1/2) and the Bcl family of proteins. Apoptosis (2013) 0.89
Prohibitin reduces mitochondrial free radical production and protects brain cells from different injury modalities. J Neurosci (2012) 0.89
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer. Oncotarget (2015) 0.86
Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens. Oncogene (2011) 0.86
Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus. Biochem Biophys Res Commun (2008) 0.85
BCL-XL regulates TNF-alpha-mediated cell death independently of NF-kappaB, FLIP and IAPs. Cell Res (2008) 0.85
Prohibitin 1 modulates mitochondrial function of Stat3. Cell Signal (2014) 0.84
miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury. Cell Death Differ (2014) 0.84
Akt phosphorylates Prohibitin 1 to mediate its mitochondrial localization and promote proliferation of bladder cancer cells. Cell Death Dis (2015) 0.83
The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cells. Sci Signal (2013) 0.83
Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis. PLoS One (2014) 0.83
Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. PLoS One (2013) 0.83
MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis. Oncotarget (2015) 0.83
Prohibitin is associated with antioxidative protection in hypoxia/reoxygenation-induced renal tubular epithelial cell injury. Sci Rep (2013) 0.82
Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria. PLoS One (2014) 0.81
MicroRNA-26a promotes tumor growth and angiogenesis in glioma by directly targeting prohibitin. CNS Neurosci Ther (2013) 0.81
Reduction of prohibitin expression contributes to left ventricular hypertrophy via enhancement of mitochondrial reactive oxygen species formation in spontaneous hypertensive rats. Free Radic Res (2014) 0.81
Liposomes decorated with Apo2L/TRAIL overcome chemoresistance of human hematologic tumor cells. Mol Pharm (2013) 0.81
A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins. Angew Chem Int Ed Engl (2014) 0.79
Prohibitin protects proximal tubule epithelial cells against oxidative injury through mitochondrial pathways. Free Radic Res (2015) 0.77