Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.

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🔗 View Article (PMC 4364945)

Published in EMBO Mol Med on February 02, 2015

Authors

Christina Ising1, Sybille Koehler1, Sebastian Brähler1, Carsten Merkwirth2, Martin Höhne3, Olivier R Baris4, Henning Hagmann1, Martin Kann1, Francesca Fabretti1, Claudia Dafinger1, Wilhelm Bloch5, Bernhard Schermer3, Andreas Linkermann6, Jens C Brüning7, Christine E Kurschat3, Roman-Ulrich Müller3, Rudolf J Wiesner4, Thomas Langer8, Thomas Benzing9, Paul Thomas Brinkkoetter10

Author Affiliations

1: Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
2: Institute for Genetics, University of Cologne, Cologne, Germany Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA, USA.
3: Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne (Sybacol) University of Cologne, Cologne, Germany.
4: Center for Physiology and Pathophysiology, Institute for Vegetative Physiology, University of Cologne, Cologne, Germany.
5: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Cologne, Germany.
6: Division of Nephrology and Hypertension, Christian-Albrechts-University, Kiel, Germany.
7: Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne (Sybacol) University of Cologne, Cologne, Germany Max Planck Institute for Metabolism Research, Cologne, Germany Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Cologne, Germany.
8: Institute for Genetics, University of Cologne, Cologne, Germany Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne (Sybacol) University of Cologne, Cologne, Germany.
9: Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne (Sybacol) University of Cologne, Cologne, Germany thomas.benzing@uk-koeln.de paul.brinkkoetter@uk-koeln.de.
10: Department II of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany thomas.benzing@uk-koeln.de paul.brinkkoetter@uk-koeln.de.

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