Published in Biomolecules on October 16, 2015
The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer. Nucleic Acids Res (2015) 0.84
Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target. Tumour Biol (2016) 0.76
The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives. Wiley Interdiscip Rev RNA (2017) 0.76
LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection. Elife (2017) 0.75
La-related protein 6 controls ciliated cell differentiation. Cilia (2017) 0.75
The RNA-binding protein LARP4 regulates cancer cell migration and invasion. Cytoskeleton (Hoboken) (2016) 0.75
Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells. PLoS One (2017) 0.75
Sumoylation in Synaptic Function and Dysfunction. Front Synaptic Neurosci (2016) 0.75
Recombinant expression and purification of the RNA-binding LARP6 proteins from fish genetic model organisms. Protein Expr Purif (2017) 0.75
ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia (2004) 17.08
Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev (2010) 12.60
Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet (2010) 10.15
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell (2005) 8.95
CDD: NCBI's conserved domain database. Nucleic Acids Res (2014) 8.25
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell (2012) 6.22
Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med (2015) 4.97
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature (2010) 4.23
Differentiation and characterization of autoantibodies and their antigens in Sjögren's syndrome. Arthritis Rheum (1976) 4.02
Cancer genomics: from discovery science to personalized medicine. Nat Med (2011) 3.66
Dissecting eIF4E action in tumorigenesis. Genes Dev (2007) 3.53
The La protein. Annu Rev Biochem (2001) 3.32
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A (2010) 3.03
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy. J Clin Invest (2011) 3.00
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell (2004) 2.91
The yeast La protein is required for the 3' endonucleolytic cleavage that matures tRNA precursors. Cell (1997) 2.86
Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's syndrome. Arthritis Rheum (1986) 2.39
LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. Nucleic Acids Res (2008) 2.38
16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J Cancer (2011) 2.32
Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. Blood (2009) 2.31
Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. Nat Struct Mol Biol (2004) 2.29
Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation. Mol Cell Biol (2000) 2.22
A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. Mol Cell (2008) 2.15
BCR/ABL activates mdm2 mRNA translation via the La antigen. Cancer Cell (2003) 2.08
7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proc Natl Acad Sci U S A (2009) 1.71
The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. EMBO Rep (2008) 1.68
Conserved and divergent features of the structure and function of La and La-related proteins (LARPs). Biochim Biophys Acta (2010) 1.58
PI3K and mTOR signaling pathways in cancer: new data on targeted therapies. Curr Oncol Rep (2012) 1.58
eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. Cancer Res (2009) 1.58
RNA sequencing of cancer reveals novel splicing alterations. Sci Rep (2013) 1.57
Sumoylation in axons triggers retrograde transport of the RNA-binding protein La. Proc Natl Acad Sci U S A (2007) 1.45
The roles of cytoplasmic poly(A)-binding proteins in regulating gene expression: a developmental perspective. Brief Funct Genomic Proteomic (2004) 1.44
A comprehensive analysis of the La-motif protein superfamily. RNA (2009) 1.44
Anti-Ro/SSA and La/SSB antibodies. Autoimmunity (2005) 1.43
Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch. EMBO J (2004) 1.36
La autoantigen enhances translation of BiP mRNA. Nucleic Acids Res (2001) 1.33
C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis. RNA (2008) 1.32
7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor. RNA Biol (2009) 1.31
La protein has a positive effect on the translation of TOP mRNAs in vivo. Nucleic Acids Res (2000) 1.31
Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen. J Mol Biol (2009) 1.30
Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol (2011) 1.30
Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Genome Res (2001) 1.28
Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development. Dev Biol (2009) 1.27
The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Dev Cell (2008) 1.27
New roles of cyclin D1. Am J Pathol (2013) 1.26
microRNAs and RNA-binding proteins: a complex network of interactions and reciprocal regulations in cancer. RNA Biol (2013) 1.26
A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. J Neurosci (2002) 1.25
Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation. Genes Dev (2014) 1.22
JAK2(V617F) negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms. Oncogene (2011) 1.21
Ribosomal protein S6 kinase from TOP mRNAs to cell size. Prog Mol Biol Transl Sci (2009) 1.21
Molecularly targeted therapies for metastatic triple-negative breast cancer. Breast Cancer Res Treat (2013) 1.21
A Xenopus laevis homologue of the La autoantigen binds the pyrimidine tract of the 5' UTR of ribosomal protein mRNAs in vitro: implication of a protein factor in complex formation. J Mol Biol (1996) 1.19
La protein is associated with terminal oligopyrimidine mRNAs in actively translating polysomes. J Biol Chem (2003) 1.19
The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability. RNA (2006) 1.18
The La protein-RNA complex surfaces. Mol Cell (2006) 1.17
Dissecting the expression landscape of RNA-binding proteins in human cancers. Genome Biol (2014) 1.17
Adverse events associated with mTOR inhibitors. Expert Opin Drug Saf (2012) 1.17
The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration. Nucleic Acids Res (2010) 1.17
Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers. Cancer Res (2002) 1.16
CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism. Mol Cell Biol (2004) 1.12
Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65. Mol Cell (2012) 1.06
LARP1 specifically recognizes the 3' terminus of poly(A) mRNA. FEBS Lett (2013) 1.05
La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition. Nucleic Acids Res (2011) 1.03
dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions. Dev Dyn (2000) 1.03
The association of initiation factor 4F with poly(A)-binding protein is enhanced in serum-stimulated Xenopus kidney cells. J Biol Chem (1999) 1.03
Precursor-product discrimination by La protein during tRNA metabolism. Nat Struct Mol Biol (2009) 1.02
The RNA-binding protein La contributes to cell proliferation and CCND1 expression. Oncogene (2010) 1.02
La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability. Mol Cell Biol (2010) 1.02
The race to decipher the top secrets of TOP mRNAs. Biochim Biophys Acta (2014) 1.02
Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein. Nucleic Acids Res (2011) 1.02
Hypoxia-induced alternative splicing in endothelial cells. PLoS One (2012) 0.99
Akt phosphorylation of La regulates specific mRNA translation in glial progenitors. Oncogene (2008) 0.99
A Drosophila orthologue of larp protein family is required for multiple processes in male meiosis. Cell Struct Funct (2007) 0.98
Binding of the La autoantigen to the 5' untranslated region of a chimeric human translation elongation factor 1A reporter mRNA inhibits translation in vitro. Biochim Biophys Acta (2001) 0.98
MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer. Int J Oncol (2015) 0.97
XRN4 and LARP1 are required for a heat-triggered mRNA decay pathway involved in plant acclimation and survival during thermal stress. Cell Rep (2013) 0.97
Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta. Gene (2007) 0.97
Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution. Biochemistry (2000) 0.95
Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA. J Biol Chem (2014) 0.95
Antinuclear antibody-negative systemic lupus erythematosus. I. Anti-Ro(SSA) and anti-La(SSB) antibodies. J Am Acad Dermatol (1981) 0.94
A stimulatory role for the La-related protein 4B in translation. RNA (2010) 0.94
Gaining momentum: New options and opportunities for the treatment of advanced melanoma. Cancer Treat Rev (2015) 0.93
LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression. Oncogene (2014) 0.93
Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis. Mol Cell Biol (2004) 0.92
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). J Biol Chem (2015) 0.91
LARP7 is a potential tumor suppressor gene in gastric cancer. Lab Invest (2012) 0.91
Implication of RNA-binding protein La in proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells. PLoS One (2011) 0.89
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP. Nucleic Acids Res (2013) 0.89
LARP1 predict the prognosis for early-stage and AFP-normal hepatocellular carcinoma. J Transl Med (2013) 0.88
RNA chaperone activity of human La protein is mediated by variant RNA recognition motif. J Biol Chem (2011) 0.87
Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module. Nucleic Acids Res (2014) 0.85
Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition. J Biol Chem (2012) 0.85
The past, present and future of immunotherapy against tumor. Transl Lung Cancer Res (2015) 0.85
Methylphosphate cap structure in small RNAs reduces the affinity of RNAs to La protein. Gene Expr (2002) 0.85
Prognostic significance of phosphorylated 4E-binding protein 1 in non-small cell lung cancer. Int J Clin Exp Pathol (2015) 0.84
The cellular protein lyric interacts with HIV-1 Gag. J Virol (2011) 0.84
Targeted therapies for treatment of renal cell carcinoma: recent advances and future perspectives. Cancer Chemother Pharmacol (2015) 0.84
Acheron, an novel LA antigen family member, binds to CASK and forms a complex with Id transcription factors. Cell Mol Biol Lett (2008) 0.84
The MDM2 gene family. Biomol Concepts (2014) 0.83