La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMC 3028612)

Published in Mol Cell Biol on November 22, 2010

Authors

Ruiqing Yang1, Sergei A Gaidamakov, Jingwei Xie, Joowon Lee, Luigi Martino, Guennadi Kozlov, Amanda K Crawford, Amy N Russo, Maria R Conte, Kalle Gehring, Richard J Maraia

Author Affiliations

1: 31 Center Drive, Bldg. 31, Room 2A25, Bethesda, MD 20892-2426, USA.

Articles citing this

Lack of tRNA modification isopentenyl-A37 alters mRNA decoding and causes metabolic deficiencies in fission yeast. Mol Cell Biol (2013) 0.95

Gene expression changes in spinal motoneurons of the SOD1(G93A) transgenic model for ALS after treatment with G-CSF. Front Cell Neurosci (2015) 0.92

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). J Biol Chem (2015) 0.91

Conservation of RNA chaperone activity of the human La-related proteins 4, 6 and 7. Nucleic Acids Res (2013) 0.90

The La-Related Proteins, a Family with Connections to Cancer. Biomolecules (2015) 0.88

The association of a La module with the PABP-interacting motif PAM2 is a recurrent evolutionary process that led to the neofunctionalization of La-related proteins. RNA (2012) 0.86

Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module. Nucleic Acids Res (2014) 0.85

The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer. Nucleic Acids Res (2015) 0.84

Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions. Wiley Interdiscip Rev RNA (2014) 0.83

La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast. RNA (2012) 0.83

The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response. PLoS Genet (2015) 0.81

LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation. RNA (2015) 0.81

Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7. Nucleic Acids Res (2015) 0.79

Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. G3 (Bethesda) (2015) 0.77

Community structure analysis of transcriptional networks reveals distinct molecular pathways for early- and late-onset temporal lobe epilepsy with childhood febrile seizures. PLoS One (2015) 0.76

The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives. Wiley Interdiscip Rev RNA (2017) 0.76

LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection. Elife (2017) 0.75

LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a Tristetraprolin-Dependent Manner. Mol Cell Biol (2015) 0.75

The RNA-binding protein LARP4 regulates cancer cell migration and invasion. Cytoskeleton (Hoboken) (2016) 0.75

The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1. Cell Signal (2017) 0.75

Handshakes and Fights: The Regulatory Interplay of RNA-Binding Proteins. Front Mol Biosci (2017) 0.75

Recombinant expression and purification of the RNA-binding LARP6 proteins from fish genetic model organisms. Protein Expr Purif (2017) 0.75

Articles cited by this

Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01

Efficient anisotropic refinement of macromolecular structures using FFT. Acta Crystallogr D Biol Crystallogr (1999) 15.91

Pushing the boundaries of molecular replacement with maximum likelihood. Acta Crystallogr D Biol Crystallogr (2001) 15.88

Macromolecular TLS refinement in REFMAC at moderate resolutions. Methods Enzymol (2003) 9.69

Translational control in stress and apoptosis. Nat Rev Mol Cell Biol (2005) 8.91

Improved nearest-neighbor parameters for predicting DNA duplex stability. Biochemistry (1996) 6.68

Eukaryotic stress granules: the ins and outs of translation. Mol Cell (2009) 6.09

Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules. J Cell Biol (2000) 5.99

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res (2007) 5.45

Purified lupus antigen La recognizes an oligouridylate stretch common to the 3' termini of RNA polymerase III transcripts. Cell (1984) 4.64

Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression. Genome Biol (2003) 4.45

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes Dev (2005) 3.92

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J (2006) 3.57

Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature (1998) 3.55

A mutant of yeast apparently defective in the initiation of protein synthesis. Proc Natl Acad Sci U S A (1969) 3.12

GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae. Mol Cell Biol (1991) 3.07

Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. Mol Cell (2006) 2.63

A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation. J Biol Chem (2002) 2.43

Translation factors promote the formation of two states of the closed-loop mRNP. Nature (2008) 2.31

Repeating structure of cytoplasmic poly(A)-ribonucleoprotein. Proc Natl Acad Sci U S A (1980) 2.30

Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep (2004) 2.28

A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. Mol Cell (2008) 2.15

General RNA binding proteins render translation cap dependent. EMBO J (1996) 2.15

La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth. Mol Cell Biol (1994) 2.04

La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA. J Virol (1994) 1.87

Advances in RIP-chip analysis : RNA-binding protein immunoprecipitation-microarray profiling. Methods Mol Biol (2008) 1.74

The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. EMBO Rep (2008) 1.68

Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases. Genes Dev (2007) 1.68

Direct link between RACK1 function and localization at the ribosome in vivo. Mol Cell Biol (2008) 1.61

Conserved and divergent features of the structure and function of La and La-related proteins (LARPs). Biochim Biophys Acta (2010) 1.58

Regulation of poly(A)-binding protein through PABP-interacting proteins. Cold Spring Harb Symp Quant Biol (2006) 1.58

Paip1 interacts with poly(A) binding protein through two independent binding motifs. Mol Cell Biol (2002) 1.55

Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. EMBO J (2003) 1.52

3'-end-dependent formation of U6 small nuclear ribonucleoprotein particles in Xenopus laevis oocyte nuclei. Mol Cell Biol (1992) 1.44

A comprehensive analysis of the La-motif protein superfamily. RNA (2009) 1.44

Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element. Structure (2003) 1.41

Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein. J Biol Chem (2007) 1.37

Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch. EMBO J (2004) 1.36

Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nat Rev Mol Cell Biol (2010) 1.36

Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein. J Biol Chem (2010) 1.34

C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis. RNA (2008) 1.32

Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen. J Mol Biol (2009) 1.30

Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. Mol Cell Biol (2008) 1.30

Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development. Dev Biol (2009) 1.27

Separate RNA-binding surfaces on the multifunctional La protein mediate distinguishable activities in tRNA maturation. Nat Struct Mol Biol (2006) 1.27

Survey on the PABC recognition motif PAM2. Biochem Biophys Res Commun (2004) 1.26

A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. J Neurosci (2002) 1.25

BTG/TOB factors impact deadenylases. Trends Biochem Sci (2009) 1.22

La protein is associated with terminal oligopyrimidine mRNAs in actively translating polysomes. J Biol Chem (2003) 1.19

Evaluation of 3D-Jury on CASP7 models. BMC Bioinformatics (2007) 1.18

The La protein-RNA complex surfaces. Mol Cell (2006) 1.17

The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration. Nucleic Acids Res (2010) 1.17

Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein. Structure (2008) 1.14

Human extracellular ribonucleases: multiplicity, molecular diversity and catalytic properties of the major RNase types. Cell Mol Life Sci (1998) 1.13

Molecular determinants of PAM2 recognition by the MLLE domain of poly(A)-binding protein. J Mol Biol (2010) 1.11

Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function. J Biol Chem (2006) 1.07

General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation. EMBO J (2008) 1.06

Precursor-product discrimination by La protein during tRNA metabolism. Nat Struct Mol Biol (2009) 1.02

Akt phosphorylation of La regulates specific mRNA translation in glial progenitors. Oncogene (2008) 0.99

Luciferase reporter gene assay in mammalian cells. Methods Enzymol (1992) 0.99

Analysis of the kinetics of transcription and replication of the rotavirus genome by RNA interference. J Virol (2009) 0.96

Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein. PLoS One (2010) 0.96

Chapter 3. Assays of adenylate uridylate-rich element-mediated mRNA decay in cells. Methods Enzymol (2008) 0.95

Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA. Nucleic Acids Res (2010) 0.94

A stimulatory role for the La-related protein 4B in translation. RNA (2010) 0.94

Phosphorylation of the Saccharomyces cerevisiae La protein does not appear to be required for its functions in tRNA maturation and nascent RNA stabilization. RNA (2001) 0.91

Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation. J Biol Chem (2010) 0.91

Nitric oxide donors inhibit luciferase expression in a promoter-independent fashion. J Biol Chem (2003) 0.88

Factors modulating expression of Renilla luciferase from control plasmids used in luciferase reporter gene assays. Anal Biochem (2009) 0.88

The end justifies the means. Nat Struct Mol Biol (2005) 0.82

Articles by these authors

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell (2005) 5.43

A role for TFIIIC transcription factor complex in genome organization. Cell (2006) 4.03

Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nat Mater (2009) 2.85

Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science (2013) 2.84

Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. Mol Cell (2007) 2.71

Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. Nat Struct Mol Biol (2004) 2.29

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell (2006) 2.24

A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. Mol Cell (2008) 2.15

Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant. Nano Lett (2009) 2.15

BCR/ABL activates mdm2 mRNA translation via the La antigen. Cancer Cell (2003) 2.08

An NMR approach to structural proteomics. Proc Natl Acad Sci U S A (2002) 1.95

Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site. Nano Lett (2009) 1.70

Protein quality control in the ER: the recognition of misfolded proteins. Semin Cell Dev Biol (2010) 1.69

Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. EMBO J (2006) 1.64

Effect of PEG conformation and particle size on the cellular uptake efficiency of nanoparticles with the HepG2 cells. J Control Release (2006) 1.62

Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Mol Cell (2007) 1.60

SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol Cell (2009) 1.59

Conserved and divergent features of the structure and function of La and La-related proteins (LARPs). Biochim Biophys Acta (2010) 1.58

Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature (2008) 1.55

Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. PLoS Biol (2007) 1.54

Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. EMBO J (2003) 1.52

BID-induced structural changes in BAK promote apoptosis. Nat Struct Mol Biol (2013) 1.45

Epidemiology and patterns of care of patients admitted to Italian Intensive Cardiac Care units: the BLITZ-3 registry. J Cardiovasc Med (Hagerstown) (2010) 1.43

Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element. Structure (2003) 1.41

A structural overview of the PDI family of proteins. FEBS J (2010) 1.38

Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein. J Biol Chem (2007) 1.37

Structure and RNA interactions of the N-terminal RRM domains of PTB. Structure (2004) 1.35

Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein. J Biol Chem (2010) 1.34

Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis. J Neurosci (2006) 1.33

Crystal structure of the bb' domains of the protein disulfide isomerase ERp57. Structure (2006) 1.33

Solution structure of the bb' domains of human protein disulfide isomerase. FEBS J (2009) 1.32

Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12. J Biol Chem (2010) 1.31

Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. Mol Cell Biol (2008) 1.30

Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs. Mol Cell (2002) 1.30

Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. J Biol Chem (2009) 1.28

Separate RNA-binding surfaces on the multifunctional La protein mediate distinguishable activities in tRNA maturation. Nat Struct Mol Biol (2006) 1.27

Structural basis of carbohydrate recognition by calreticulin. J Biol Chem (2010) 1.25

Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs. Mol Cell (2003) 1.25

Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing. Mol Cell Biol (2005) 1.24

Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). Proc Natl Acad Sci U S A (2012) 1.23

Structural insights into molecular function of the metastasis-associated phosphatase PRL-3. J Biol Chem (2004) 1.22

Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. J Biol Chem (2003) 1.19

Specific interaction of ERp57 and calnexin determined by NMR spectroscopy and an ER two-hybrid system. EMBO J (2004) 1.16

Coating electrospun poly(epsilon-caprolactone) fibers with gelatin and calcium phosphate and their use as biomimetic scaffolds for bone tissue engineering. Langmuir (2008) 1.16

Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein. Structure (2008) 1.14

CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism. Mol Cell Biol (2004) 1.12

Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions. J Mol Biol (2002) 1.11

ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity. J Biol Chem (2009) 1.11

Molecular determinants of PAM2 recognition by the MLLE domain of poly(A)-binding protein. J Mol Biol (2010) 1.11

Interdomain allostery promotes assembly of the poly(A) mRNA complex with PABP and eIF4G. Mol Cell (2012) 1.10

In support of the BMRB. Nat Struct Mol Biol (2012) 1.09

Stability and binding properties of a modified thrombin binding aptamer. Biophys J (2007) 1.09

Structural basis of substrate recognition and specificity in the N-end rule pathway. Nat Struct Mol Biol (2010) 1.09

Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles. Biochemistry (2006) 1.08

Structural basis of defects in the sacsin HEPN domain responsible for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). J Biol Chem (2011) 1.08

Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD. EMBO J (2008) 1.07

Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function. J Biol Chem (2006) 1.07

Solution structure of the carbon storage regulator protein CsrA from Escherichia coli. J Bacteriol (2005) 1.07

Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain. J Biol Chem (2010) 1.05

Structural and functional relationships between the lectin and arm domains of calreticulin. J Biol Chem (2011) 1.05

Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase superfamily. J Biol Chem (2003) 1.04

tRNAomics: tRNA gene copy number variation and codon use provide bioinformatic evidence of a new anticodon:codon wobble pair in a eukaryote. RNA (2012) 1.04

Transcription termination by the eukaryotic RNA polymerase III. Biochim Biophys Acta (2012) 1.04

Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2. EMBO J (2004) 1.03

Precursor-product discrimination by La protein during tRNA metabolism. Nat Struct Mol Biol (2009) 1.02

Apoptotic regulation by MCL-1 through heterodimerization. J Biol Chem (2010) 1.02

Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein. Nucleic Acids Res (2011) 1.02

Human La is found at RNA polymerase III-transcribed genes in vivo. Proc Natl Acad Sci U S A (2005) 1.01

Chitosan-Based Inverse Opals: Three-Dimensional Scaffolds with Uniform Pore Structures for Cell Culture. Adv Mater (2009) 1.01

Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72. Structure (2009) 1.00

Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Eur J Pediatr (2006) 1.00

Cellular La protein shields nonsegmented negative-strand RNA viral leader RNA from RIG-I and enhances virus growth by diverse mechanisms. J Virol (2008) 0.98

Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturation. Mol Cell Biol (2007) 0.98

NMR structural study of TcUBP1, a single RRM domain protein from Trypanosoma cruzi: contribution of a beta hairpin to RNA binding. Biochemistry (2005) 0.98

Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD. J Biol Chem (2007) 0.97

Heat-induced dimerization of BCL-xL through alpha-helix swapping. Biochemistry (2007) 0.97

Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase. J Biol Chem (2007) 0.96

Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein. PLoS One (2010) 0.96

An interaction map of endoplasmic reticulum chaperones and foldases. Mol Cell Proteomics (2012) 0.96

Lack of tRNA modification isopentenyl-A37 alters mRNA decoding and causes metabolic deficiencies in fission yeast. Mol Cell Biol (2013) 0.95

RNA polymerase III mutants in TFIIFα-like C37 that cause terminator readthrough with no decrease in transcription output. Nucleic Acids Res (2012) 0.95

Selective inhibitory DNA aptamers of the human RNase H1. Nucleic Acids Res (2003) 0.95

Phylogenetic distribution and predominant genotype of the avian infectious bronchitis virus in China during 2008-2009. Virol J (2011) 0.95

The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells. Mol Cell Biol (2006) 0.95

Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation. Transcription (2014) 0.95