Published in Genes (Basel) on October 21, 2015
Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq. Oncotarget (2016) 0.76
Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures. Mol Cell Proteomics (2017) 0.75
Gene mutations and actionable genetic lesions in mantle cell lymphoma. Oncotarget (2016) 0.75
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell (2010) 16.12
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet (2010) 10.97
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature (2011) 9.71
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57
IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95
Epigenetics in cancer. Carcinogenesis (2009) 7.49
A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med (2006) 7.42
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell (2007) 6.07
Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet (2011) 6.06
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol (2006) 5.16
CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature (2010) 4.86
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci U S A (2010) 4.52
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature (2012) 4.33
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol (2006) 3.54
Understanding the language of Lys36 methylation at histone H3. Nat Rev Mol Cell Biol (2012) 3.52
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28
Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell (2010) 3.25
Genetic heterogeneity of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A (2013) 3.25
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell (2013) 3.13
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature (2009) 3.13
Interplay between the cancer genome and epigenome. Cell (2013) 3.05
The genetic landscape of mutations in Burkitt lymphoma. Nat Genet (2012) 3.03
H3K27 demethylases, at long last. Cell (2007) 3.02
Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J (2009) 2.72
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood (2010) 2.71
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2012) 2.70
The molecular biology of mixed lineage leukemia. Haematologica (2009) 2.58
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev (2013) 2.31
DNA methylation: TET proteins-guardians of CpG islands? EMBO Rep (2011) 2.23
Histone lysine methylation and demethylation pathways in cancer. Biochim Biophys Acta (2010) 2.10
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Proc Natl Acad Sci U S A (2013) 2.00
Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell (2012) 1.98
New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. Blood (2008) 1.97
Role for BRG1 in cell cycle control and tumor suppression. Mol Cell Biol (2004) 1.82
Epigenetic mechanisms in neurological disease. Nat Med (2012) 1.74
Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. J Biol Chem (2003) 1.71
Programming of gene expression by Polycomb group proteins. Trends Cell Biol (2008) 1.66
KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. Cancer Res (2013) 1.65
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem (2009) 1.61
New concepts in DNA methylation. Trends Biochem Sci (2014) 1.60
SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Rep (2014) 1.57
An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. PLoS One (2010) 1.52
SREBPs: sterol-regulated transcription factors. J Cell Sci (2006) 1.48
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Blood (2011) 1.40
Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. Proc Natl Acad Sci U S A (2008) 1.28
EZH2 in normal and malignant hematopoiesis. Leukemia (2013) 1.28
Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells. Cell Rep (2012) 1.27
L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov (2014) 1.26
Coordinate regulation of DNA methylation and H3K27me3 in mouse embryonic stem cells. PLoS One (2013) 1.24
Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins. PLoS Genet (2013) 1.23
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. J Clin Invest (2013) 1.19
Promoter-specific activation and demethylation by MBD2/demethylase. J Biol Chem (2002) 1.19
Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups. Acta Neuropathol (2015) 1.16
IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells. J Lipid Res (2003) 1.13
A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice. Nat Commun (2014) 1.12
Interactions between epigenetics and metabolism in cancers. Front Oncol (2012) 1.11
Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. Cell Res (2012) 1.08
The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood (2014) 1.08
KEGGParser: parsing and editing KEGG pathway maps in Matlab. Bioinformatics (2013) 1.07
Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin. Genes Dev (2013) 1.04
Context-specific regulation of cancer epigenomes by histone and transcription factor methylation. Oncogene (2013) 0.99
Epigenetics and B-cell lymphoma. Curr Opin Hematol (2011) 0.98
Epigenetic alterations in hematopoietic malignancies. Int J Hematol (2012) 0.98
Expression cartography of human tissues using self organizing maps. BMC Bioinformatics (2011) 0.96
KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation. Genome Biol (2014) 0.95
Structure and function of SWI/SNF chromatin remodeling complexes and mechanistic implications for transcription. Prog Biophys Mol Biol (2010) 0.95
Cell reprogramming requires silencing of a core subset of polycomb targets. PLoS Genet (2013) 0.95
Silencing SMYD3 in hepatoma demethylates RIZI promoter induces apoptosis and inhibits cell proliferation and migration. World J Gastroenterol (2007) 0.91
RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation. Nucleic Acids Res (2014) 0.91
Molecular characterization of long-term survivors of glioblastoma using genome- and transcriptome-wide profiling. Int J Cancer (2014) 0.91
Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Mol Cell Neurosci (2013) 0.88
Mining SOM expression portraits: feature selection and integrating concepts of molecular function. BioData Min (2012) 0.87
Polycomb genes, miRNA, and their deregulation in B-cell malignancies. Blood (2015) 0.87
Portraying the Expression Landscapes of B-CellLymphoma-Intuitive Detection of Outlier Samples and of Molecular Subtypes. Biology (Basel) (2013) 0.83
Quantitative epigenetic co-variation in CpG islands and co-regulation of developmental genes. Sci Rep (2013) 0.81
Epigenetic Heterogeneity of B-Cell Lymphoma: DNA Methylation, Gene Expression and Chromatin States. Genes (Basel) (2015) 0.80
B-cell lymphoma mutations: improving diagnostics and enabling targeted therapies. Haematologica (2014) 0.80
oposSOM: R-package for high-dimensional portraying of genome-wide expression landscapes on bioconductor. Bioinformatics (2015) 0.80
A new horizon for epigenetic medicine? Cell Res (2012) 0.80
Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growth. Genome Res (2013) 0.79
Time-course human urine proteomics in space-flight simulation experiments. BMC Genomics (2014) 0.78
Massive transcriptional perturbation in subgroups of diffuse large B-cell lymphomas. PLoS One (2013) 0.77
MLL/KMT2A translocations in diffuse large B-cell lymphomas. Hematol Oncol (2014) 0.76