Published in Cell on October 29, 2010
A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer (2011) 11.33
Regulation of chromatin by histone modifications. Cell Res (2011) 8.44
DNA methylation: roles in mammalian development. Nat Rev Genet (2013) 6.65
Pioneer transcription factors: establishing competence for gene expression. Genes Dev (2011) 6.01
NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 5.77
Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet (2012) 5.42
Understanding the language of Lys36 methylation at histone H3. Nat Rev Mol Cell Biol (2012) 3.52
Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res (2011) 3.36
Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell (2013) 3.09
A double take on bivalent promoters. Genes Dev (2013) 2.79
Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol (2012) 2.76
Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk. Genome Res (2012) 2.49
Readers of histone modifications. Cell Res (2011) 2.40
Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues. Nat Genet (2012) 2.20
Operating on chromatin, a colorful language where context matters. J Mol Biol (2011) 2.00
Interpreting the language of histone and DNA modifications. Biochim Biophys Acta (2014) 1.80
Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein. J Biol Chem (2011) 1.79
Detection of β cell death in diabetes using differentially methylated circulating DNA. Proc Natl Acad Sci U S A (2011) 1.77
GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination. Genome Res (2013) 1.71
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. J Mol Biol (2012) 1.69
Meier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplication. Genes Dev (2012) 1.66
MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome. Proc Natl Acad Sci U S A (2015) 1.63
DNA methylation presents distinct binding sites for human transcription factors. Elife (2013) 1.63
Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity. Nucleic Acids Res (2013) 1.55
Tet1 and 5-hydroxymethylation: a genome-wide view in mouse embryonic stem cells. Cell Cycle (2011) 1.51
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes. Genome Biol (2013) 1.47
DNA methylation reprogramming in cancer: does it act by re-configuring the binding landscape of Polycomb repressive complexes? Bioessays (2013) 1.45
Chromatin as an expansive canvas for chemical biology. Nat Chem Biol (2012) 1.45
DNA methylation analysis of the macrosatellite repeat associated with FSHD muscular dystrophy at single nucleotide level. PLoS One (2014) 1.44
Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment. Cell Rep (2014) 1.43
DNA methylation in an intron of the IBM1 histone demethylase gene stabilizes chromatin modification patterns. EMBO J (2012) 1.33
Quantitative proteomic analysis of histone modifications. Chem Rev (2015) 1.32
Mediator coordinates PIC assembly with recruitment of CHD1. Genes Dev (2011) 1.28
Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. Nature (2013) 1.27
Genome-wide analysis of histone H3.1 and H3.3 variants in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2012) 1.27
Proteomic characterization of novel histone post-translational modifications. Epigenetics Chromatin (2013) 1.26
Helicase loading at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.26
Coordinate regulation of DNA methylation and H3K27me3 in mouse embryonic stem cells. PLoS One (2013) 1.24
Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells. Genome Biol (2013) 1.22
Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1. Proc Natl Acad Sci U S A (2012) 1.22
Harnessing the potential of epigenetic therapy to target solid tumors. J Clin Invest (2014) 1.20
Proteomic analysis of coregulators bound to ERα on DNA and nucleosomes reveals coregulator dynamics. Mol Cell (2013) 1.17
Quantitative chemical proteomics approach to identify post-translational modification-mediated protein-protein interactions. J Am Chem Soc (2012) 1.12
Histone modifiers in cancer: friends or foes? Genes Cancer (2011) 1.10
Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. PLoS Genet (2014) 1.10
Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries. Nat Methods (2014) 1.08
Principles of nucleation of H3K27 methylation during embryonic development. Genome Res (2013) 1.06
Chromatin as an oxygen sensor and active player in the hypoxia response. Cell Signal (2011) 1.05
The roles of Jumonji-type oxygenases in human disease. Epigenomics (2014) 1.05
Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways. J Cell Biochem (2011) 1.05
The origin recognition complex: a biochemical and structural view. Subcell Biochem (2012) 1.05
Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation. Mol Cell (2015) 1.03
MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain. Nucleic Acids Res (2011) 1.03
On WD40 proteins: propelling our knowledge of transcriptional control? Epigenetics (2012) 1.03
Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. Mol Cell Proteomics (2012) 1.03
Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns. Mol Cell Proteomics (2011) 1.03
A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein. PLoS One (2011) 1.03
Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation. Mol Cell Biol (2012) 1.02
Histones: at the crossroads of peptide and protein chemistry. Chem Rev (2014) 1.01
Post-translational modifications of histones that influence nucleosome dynamics. Chem Rev (2014) 0.99
Regulation of gene transcription by Polycomb proteins. Sci Adv (2015) 0.99
Mass spectrometry-based proteomics for the analysis of chromatin structure and dynamics. Int J Mol Sci (2013) 0.97
Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing. J Biol Chem (2012) 0.96
The Tudor domain protein Spindlin1 is involved in intrinsic antiviral defense against incoming hepatitis B Virus and herpes simplex virus type 1. PLoS Pathog (2014) 0.96
Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO Rep (2011) 0.95
Tudor: a versatile family of histone methylation 'readers'. Trends Biochem Sci (2013) 0.94
Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. Cell Stem Cell (2015) 0.94
The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components. Mol Cell Proteomics (2013) 0.93
Proteins that bind regulatory regions identified by histone modification chromatin immunoprecipitations and mass spectrometry. Nat Commun (2015) 0.93
Cdyl, a new partner of the inactive X chromosome and potential reader of H3K27me3 and H3K9me2. Mol Cell Biol (2013) 0.92
The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers. PLoS One (2011) 0.92
Identification and interrogation of combinatorial histone modifications. Front Genet (2013) 0.91
Promiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More? Front Immunol (2015) 0.90
The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin. Elife (2015) 0.90
Balancing chromatin remodeling and histone modifications in transcription. Trends Genet (2013) 0.90
Orc2 protects ORCA from ubiquitin-mediated degradation. Cell Cycle (2012) 0.89
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex. Nature (2016) 0.88
USP11 regulates PML stability to control Notch-induced malignancy in brain tumours. Nat Commun (2014) 0.88
Epigenetic regulation of stem cells differentiating along the neural lineage. Curr Opin Neurobiol (2012) 0.88
The interaction of PRC2 with RNA or chromatin is mutually antagonistic. Genome Res (2016) 0.88
High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins. EMBO J (2013) 0.88
SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation. Nat Commun (2015) 0.87
The ChroP approach combines ChIP and mass spectrometry to dissect locus-specific proteomic landscapes of chromatin. J Vis Exp (2014) 0.87
DNA methylation determines nucleosome occupancy in the 5'-CpG islands of tumor suppressor genes. Oncogene (2013) 0.86
Calibrating ChIP-Seq with Nucleosomal Internal Standards to Measure Histone Modification Density Genome Wide. Mol Cell (2015) 0.85
Dietary alleviation of maternal obesity and diabetes: increased resistance to diet-induced obesity transcriptional and epigenetic signatures. PLoS One (2013) 0.85
The histone code reader SPIN1 controls RET signaling in liposarcoma. Oncotarget (2015) 0.85
H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing. Epigenetics Chromatin (2011) 0.85
The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression. Curr Top Microbiol Immunol (2012) 0.84
A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin. PLoS One (2012) 0.84
Proteomics in epigenetics: new perspectives for cancer research. Brief Funct Genomics (2013) 0.84
Linking DNA replication to heterochromatin silencing and epigenetic inheritance. Acta Biochim Biophys Sin (Shanghai) (2012) 0.84
Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. J Mol Biol (2012) 0.84
Chromatin enrichment for proteomics. Nat Protoc (2014) 0.84
Recruiting polycomb to chromatin. Int J Biochem Cell Biol (2015) 0.83
Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation. Nat Commun (2015) 0.83
Biotinylation of lysine 16 in histone H4 contributes toward nucleosome condensation. Arch Biochem Biophys (2012) 0.83
Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis. Cancers (Basel) (2012) 0.83
Cancer genomics identifies disrupted epigenetic genes. Hum Genet (2013) 0.83
Role of macrophage receptor with collagenous structure in innate immune tolerance. J Immunol (2013) 0.83
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Chromatin modifications and their function. Cell (2007) 55.98
Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature (2001) 19.54
The mammalian epigenome. Cell (2007) 18.13
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98
New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning. J Mol Biol (1998) 10.73
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol (2008) 5.55
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature (2005) 5.15
Reconstitution of nucleosome core particles from recombinant histones and DNA. Methods Enzymol (2004) 4.57
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell (2010) 4.31
The site-specific installation of methyl-lysine analogs into recombinant histones. Cell (2007) 4.22
Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell (1997) 4.02
Semisynthesis of proteins by expressed protein ligation. Annu Rev Biochem (2003) 3.44
A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation. Mol Cell (2009) 3.11
MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. Mol Cell Biol (2006) 3.05
Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol (2006) 2.99
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. EMBO J (2004) 2.87
CpG islands recruit a histone H3 lysine 36 demethylase. Mol Cell (2010) 2.86
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell (2010) 2.77
ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation. Mol Cell Biol (2007) 2.69
KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle (2008) 1.90
Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones. J Am Chem Soc (2009) 1.60
A native peptide ligation strategy for deciphering nucleosomal histone modifications. J Biol Chem (2003) 1.53
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics (2009) 1.45
A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly. Genes Dev (2010) 1.37
Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes. Int J Dev Biol (2009) 1.29
Two chromatin remodeling activities cooperate during activation of hormone responsive promoters. PLoS Genet (2009) 1.22
JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation. EMBO J (2010) 1.17
New methods for proteomic research: preparation of proteins with N-terminal cysteines for labeling and conjugation. Angew Chem Int Ed Engl (2002) 1.14
Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation. J Biol Chem (2006) 1.01
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol (2008) 38.00
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics (2002) 30.58
Mass spectrometry-based proteomics. Nature (2003) 28.94
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell (2006) 20.92
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (2009) 20.49
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev (2002) 19.24
Universal sample preparation method for proteome analysis. Nat Methods (2009) 16.88
In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc (2006) 16.56
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
Andromeda: a peptide search engine integrated into the MaxQuant environment. J Proteome Res (2011) 14.82
Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics. Anal Chem (2003) 13.58
Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat Protoc (2007) 10.71
Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Mol Cell Proteomics (2005) 10.67
Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol Cell Proteomics (2005) 10.60
Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast. Nature (2008) 10.28
The minimum information about a proteomics experiment (MIAPE). Nat Biotechnol (2007) 10.24
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol (2003) 8.82
Proteomic characterization of the human centrosome by protein correlation profiling. Nature (2003) 8.74
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal (2010) 8.61
Regulation of chromatin by histone modifications. Cell Res (2011) 8.44
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature (2011) 8.29
Cancer epigenetics: from mechanism to therapy. Cell (2012) 7.74
Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A (2002) 7.67
Mass spectrometry-based proteomics turns quantitative. Nat Chem Biol (2005) 7.52
Nucleolar proteome dynamics. Nature (2005) 7.32
Directed proteomic analysis of the human nucleolus. Curr Biol (2002) 7.04
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proc Natl Acad Sci U S A (2003) 6.87
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell (2003) 6.77
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell (2007) 6.62
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J (2002) 6.37
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature (2002) 6.26
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature (2002) 6.09
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science (2002) 6.05
Large-scale proteomic analysis of the human spliceosome. Genome Res (2002) 5.75
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature (2005) 5.72
Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry. Nature (2002) 5.48
Deep proteome and transcriptome mapping of a human cancer cell line. Mol Syst Biol (2011) 5.48
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell (2008) 5.38
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics. Nat Biotechnol (2004) 5.22
A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC). Nat Protoc (2006) 5.21
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci (2003) 5.19
Histone deimination antagonizes arginine methylation. Cell (2004) 5.19
Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway. Mol Cell Proteomics (2005) 5.07
Higher-energy C-trap dissociation for peptide modification analysis. Nat Methods (2007) 5.04
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell (2008) 5.02
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell (2004) 4.99
Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors. Proc Natl Acad Sci U S A (2003) 4.87
A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics. Nat Protoc (2009) 4.84
Trypsin cleaves exclusively C-terminal to arginine and lysine residues. Mol Cell Proteomics (2004) 4.79
Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Cell (2005) 4.78
Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes. J Biol Chem (2005) 4.78
A dual pressure linear ion trap Orbitrap instrument with very high sequencing speed. Mol Cell Proteomics (2009) 4.75
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem (2002) 4.70
PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites. Genome Biol (2007) 4.66
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature (2009) 4.60
Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature (2007) 4.55
A mammalian organelle map by protein correlation profiling. Cell (2006) 4.54
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics (2011) 4.40
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res (2003) 4.36
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell (2003) 4.33
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell (2010) 4.31
An operational definition of epigenetics. Genes Dev (2009) 4.26
The ABC's (and XYZ's) of peptide sequencing. Nat Rev Mol Cell Biol (2004) 4.24
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20
Paraspeckles: a novel nuclear domain. Curr Biol (2002) 4.19
Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell (2013) 4.16
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. Immunity (2010) 4.03
Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. Mol Cell (2006) 3.98
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev (2002) 3.80
The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol (2006) 3.79
Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics (2008) 3.78
Decoding signalling networks by mass spectrometry-based proteomics. Nat Rev Mol Cell Biol (2010) 3.78
Proteome analysis of separated male and female gametocytes reveals novel sex-specific Plasmodium biology. Cell (2005) 3.77
Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer. Mol Cell Proteomics (2011) 3.75
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol (2006) 3.65
Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions. J Cell Biol (2010) 3.61
Precision mapping of an in vivo N-glycoproteome reveals rigid topological and sequence constraints. Cell (2010) 3.60
Stable isotope labeling by amino acids in cell culture (SILAC) and proteome quantitation of mouse embryonic stem cells to a depth of 5,111 proteins. Mol Cell Proteomics (2007) 3.60
Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins. Mol Cell Proteomics (2012) 3.57
Combination of FASP and StageTip-based fractionation allows in-depth analysis of the hippocampal membrane proteome. J Proteome Res (2009) 3.56
Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins. Curr Biol (2007) 3.55
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. Nat Biotechnol (2003) 3.54
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell (2013) 3.53
More than 100,000 detectable peptide species elute in single shotgun proteomics runs but the majority is inaccessible to data-dependent LC-MS/MS. J Proteome Res (2011) 3.53
System-wide changes to SUMO modifications in response to heat shock. Sci Signal (2009) 3.50
Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol (2005) 3.48
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Mol Cell (2003) 3.47
Improved peptide identification in proteomics by two consecutive stages of mass spectrometric fragmentation. Proc Natl Acad Sci U S A (2004) 3.43
Mass spectrometric-based approaches in quantitative proteomics. Methods (2003) 3.38
Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science (2005) 3.37
Status of complete proteome analysis by mass spectrometry: SILAC labeled yeast as a model system. Genome Biol (2006) 3.34
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature (2007) 3.32
Quantitative, high-resolution proteomics for data-driven systems biology. Annu Rev Biochem (2011) 3.19