Published in World J Stem Cells on October 26, 2015
Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy. Stem Cells Int (2016) 0.78
Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications. Stem Cells Int (2017) 0.77
Short-term EGFR blockade enhances immune-mediated cytotoxicity of EGFR mutant lung cancer cells: rationale for combination therapies. Cell Death Dis (2016) 0.75
Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer (2017) 0.75
Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction. FEBS Open Bio (2017) 0.75
Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma. J Cancer (2017) 0.75
Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance. Med Res Rev (2016) 0.75
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63
Identification of a cancer stem cell in human brain tumors. Cancer Res (2003) 24.02
Shared principles in NF-kappaB signaling. Cell (2008) 20.96
Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med (1996) 17.51
Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35
Tumour stem cells and drug resistance. Nat Rev Cancer (2005) 15.21
Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell (2009) 12.96
Tumor growth need not be driven by rare cancer stem cells. Science (2007) 10.34
MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem (2007) 6.88
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med (2011) 6.85
Cancer drug resistance: an evolving paradigm. Nat Rev Cancer (2013) 6.77
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov (2009) 6.36
CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res (2007) 6.21
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest (2008) 5.96
Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med (2006) 5.92
CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res (2010) 5.42
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell (2009) 5.30
Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology (2006) 4.61
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. Curr Opin Cell Biol (2009) 4.56
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20
Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells (2009) 4.08
The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood (2002) 4.02
Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res (2006) 3.90
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A (2003) 3.72
Characterization of a side population of cancer cells from human gastrointestinal system. Stem Cells (2005) 3.66
Eyes wide open: a critical review of sphere-formation as an assay for stem cells. Cell Stem Cell (2011) 3.55
Preferential induction of apoptosis for primary human leukemic stem cells. Proc Natl Acad Sci U S A (2002) 3.12
CD44 cell adhesion molecules. Mol Pathol (1999) 2.89
Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res (2010) 2.77
Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Blood (2011) 2.69
Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene (2006) 2.60
Targeting Hedgehog--a cancer stem cell pathway. Clin Cancer Res (2010) 2.50
Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control (2003) 2.46
Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. J Exp Med (2011) 2.40
Can we safely target the WNT pathway? Nat Rev Drug Discov (2014) 2.31
Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Cancer Res (2010) 2.25
Mechanisms of chemoresistance in cancer stem cells. Clin Transl Med (2013) 2.20
Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev (2008) 2.08
Differentiation therapy exerts antitumor effects on stem-like glioma cells. Clin Cancer Res (2010) 2.07
Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma. Int J Cancer (2008) 2.06
Cancer stem cells in the development of liver cancer. J Clin Invest (2013) 2.06
CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Proc Natl Acad Sci U S A (2007) 1.99
CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway. Biochem Biophys Res Commun (2007) 1.96
Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther (2013) 1.96
Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proc Natl Acad Sci U S A (2012) 1.86
Antibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in mice. Gastroenterology (2014) 1.85
Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol Sin (2013) 1.83
Combining two strategies to improve perfusion and drug delivery in solid tumors. Proc Natl Acad Sci U S A (2013) 1.83
Mir-34: a new weapon against cancer? Mol Ther Nucleic Acids (2014) 1.81
The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. Blood (2007) 1.81
Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci U S A (2012) 1.80
Wnt signaling in stem and cancer stem cells. Semin Cell Dev Biol (2010) 1.79
Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Sci Transl Med (2010) 1.78
Generation of human induced pluripotent stem cells from urine samples. Nat Protoc (2012) 1.76
Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker. Proc Natl Acad Sci U S A (2011) 1.71
TRAIL-expressing mesenchymal stem cells kill the putative cancer stem cell population. Br J Cancer (2010) 1.65
Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth. Breast Cancer Res (2011) 1.64
The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization. Blood (2013) 1.63
Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle (2009) 1.56
PTEN, stem cells, and cancer stem cells. J Biol Chem (2008) 1.52
MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression. J Exp Clin Cancer Res (2010) 1.51
Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Cell Death Dis (2013) 1.51
Colorectal cancer stem cells. Stem Cells (2012) 1.47
Cancer stem cells in lung cancer: Evidence and controversies. Respirology (2013) 1.46
Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells. Oncogene (2010) 1.45
MicroRNA-21 promotes the cell proliferation, invasion and migration abilities in ovarian epithelial carcinomas through inhibiting the expression of PTEN protein. Int J Mol Med (2010) 1.44
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res (2013) 1.43
Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm (2011) 1.42
NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells. Breast Cancer Res Treat (2007) 1.39
Notch signaling: switching an oncogene to a tumor suppressor. Blood (2014) 1.32
CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers. BMC Cancer (2011) 1.31
MicroRNAs: regulators of oncogenesis and stemness. BMC Med (2008) 1.29
Systemic buffers inhibit carcinogenesis in TRAMP mice. J Urol (2012) 1.28
Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells. Leukemia (2012) 1.25
Identification of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cell line. Mol Cell Biochem (2007) 1.25
Evolution of the cancer genome. Trends Genet (2012) 1.22
CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts. Br J Cancer (2009) 1.20
VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Clin Cancer Res (2004) 1.13
Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells. Stem Cell Reports (2015) 1.13
Role of CD44 in tumour progression and strategies for targeting. J Drug Target (2012) 1.12
Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells. Hepatology (2012) 1.11
The microRNA miR-34a inhibits non-small cell lung cancer (NSCLC) growth and the CD44hi stem-like NSCLC cells. PLoS One (2014) 1.11
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer. J Clin Invest (2012) 1.10
The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression. Clin Cancer Res (2013) 1.10
Oncogene-induced plasticity and cancer stem cells. Cell Cycle (2007) 1.05
HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells. Mol Cancer Res (2014) 1.05
Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer. Cancer Treat Rev (2014) 1.05
Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis. Clin Cancer Res (2011) 1.04
Hypoxia inducible factor pathway inhibitors as anticancer therapeutics. Future Med Chem (2013) 1.03
Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency. Clin Cancer Res (2015) 1.02
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. Leukemia (2002) 1.02
Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis. Mol Cancer Ther (2013) 1.02
Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation. Int J Cancer (2014) 1.01
Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection. Biosci Rep (2011) 1.01
Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats. Neuro Oncol (2013) 1.01