Identification of gastric cancer stem cells using the cell surface marker CD44.

PubWeight™: 4.08‹?› | Rank: Top 1%

🔗 View Article (PMC 2746367)

Published in Stem Cells on May 01, 2009

Authors

Shigeo Takaishi1, Tomoyuki Okumura, Shuiping Tu, Sophie S W Wang, Wataru Shibata, Ramanathan Vigneshwaran, Shanisha A K Gordon, Yutaka Shimada, Timothy C Wang

Author Affiliations

1: Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

Articles citing this

(truncated to the top 100)

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med (2011) 6.85

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation. BMC Biol (2012) 2.70

Tackling the cancer stem cells - what challenges do they pose? Nat Rev Drug Discov (2014) 2.55

Denervation suppresses gastric tumorigenesis. Sci Transl Med (2014) 1.96

Antibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in mice. Gastroenterology (2014) 1.85

Gastric cancer-molecular and clinical dimensions. Nat Rev Clin Oncol (2013) 1.72

More than markers: biological significance of cancer stem cell-defining molecules. Mol Cancer Ther (2010) 1.60

Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression. Stem Cells (2011) 1.50

Understanding the cancer stem cell. Br J Cancer (2010) 1.42

Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance. Cancer Res (2010) 1.38

Stem cells and cancer of the stomach and intestine. Mol Oncol (2010) 1.37

A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. Mol Cell (2014) 1.34

Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology (2009) 1.31

Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. PLoS One (2011) 1.30

The spatial distribution of LGR5+ cells correlates with gastric cancer progression. PLoS One (2012) 1.26

The multiple facets of drug resistance: one history, different approaches. J Exp Clin Cancer Res (2014) 1.25

Identification of CD44+CD24+ gastric cancer stem cells. J Cancer Res Clin Oncol (2011) 1.25

Stem cells in gastroenterology and hepatology. Nat Rev Gastroenterol Hepatol (2009) 1.23

Sequential expression of putative stem cell markers in gastric carcinogenesis. Br J Cancer (2011) 1.22

The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade. Cancer Microenviron (2010) 1.21

Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med (2011) 1.20

Mullerian inhibiting substance preferentially inhibits stem/progenitors in human ovarian cancer cell lines compared with chemotherapeutics. Proc Natl Acad Sci U S A (2010) 1.20

Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment. Cell Death Dis (2014) 1.17

Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44. PLoS One (2011) 1.16

The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation. J Biol Chem (2013) 1.14

Spheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftment. PLoS One (2011) 1.14

Aldehyde dehydrogenase 1 identifies cells with cancer stem cell-like properties in a human renal cell carcinoma cell line. PLoS One (2013) 1.11

The Role of CD44 in the Pathogenesis, Diagnosis, and Therapy of Gastric Cancer. Gut Liver (2011) 1.11

The role of microRNAs in the regulation of cancer stem cells. Front Genet (2014) 1.09

Akt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency. Nat Commun (2013) 1.09

Mouse models of gastric cancer. Cancers (Basel) (2013) 1.07

Role of oxidative stress in stem, cancer, and cancer stem cells. Cancers (Basel) (2010) 1.06

Role of epithelial-mesenchymal transition in gastric cancer initiation and progression. World J Gastroenterol (2014) 1.06

Current molecular markers for gastric progenitor cells and gastric cancer stem cells. J Gastroenterol (2011) 1.05

Gastric cancer stem cells: a novel therapeutic target. Cancer Lett (2013) 1.04

Characteristics of CD44 alternative splice pattern in the course of human colorectal adenocarcinoma progression. Mol Cancer (2012) 1.04

Genotypic and phenotypic characterization of side population of gastric cancer cell lines. Am J Pathol (2011) 1.03

Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer. Oncol Rep (2012) 1.03

Identification of stem-like cells and clinical significance of candidate stem cell markers in gastric cancer. Oncotarget (2016) 1.02

New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells. Mol Cancer (2010) 1.01

Frequent gene amplification predicts poor prognosis in gastric cancer. Int J Mol Sci (2012) 1.00

Lung cancer tumorigenicity and drug resistance are maintained through ALDH(hi)CD44(hi) tumor initiating cells. Oncotarget (2013) 1.00

Spheroid body-forming cells in the human gastric cancer cell line MKN-45 possess cancer stem cell properties. Int J Oncol (2012) 1.00

Gastric carcinogenesis and the cancer stem cell hypothesis. Gastric Cancer (2010) 1.00

Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target. Stem Cells Transl Med (2015) 0.99

Cancer stem cells: a novel paradigm for cancer prevention and treatment. Mini Rev Med Chem (2010) 0.99

Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells. Gastric Cancer (2012) 0.99

ABC transporters in CSCs membranes as a novel target for treating tumor relapse. Front Pharmacol (2014) 0.98

Surgical treatment for patients with Krukenberg tumor of stomach origin: clinical outcome and prognostic factors analysis. PLoS One (2013) 0.98

Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy. Oncotarget (2015) 0.97

Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97

Cancer stem cells in basic science and in translational oncology: can we translate into clinical application? J Hematol Oncol (2015) 0.96

Emerging role of nanog in tumorigenesis and cancer stem cells. Int J Cancer (2014) 0.96

Stem cells in gastric cancer. World J Gastroenterol (2015) 0.96

CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog (2015) 0.96

What makes cancer stem cell markers different? Springerplus (2013) 0.96

Characterization of LGR5 stem cells in colorectal adenomas and carcinomas. Sci Rep (2015) 0.95

CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance. Clin Cancer Res (2014) 0.95

Multispecies model of cell lineages and feedback control in solid tumors. J Theor Biol (2012) 0.95

Coaction of spheroid-derived stem-like cells and endothelial progenitor cells promotes development of colon cancer. PLoS One (2012) 0.95

Key Roles of Hyaluronan and Its CD44 Receptor in the Stemness and Survival of Cancer Stem Cells. Front Oncol (2015) 0.95

Cancer stem cell hypothesis and gastric carcinogenesis: Experimental evidence and unsolved questions. World J Gastrointest Oncol (2012) 0.95

Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis. World J Gastrointest Pathophysiol (2014) 0.94

Expression and significance of CD44, CD47 and c-met in ovarian clear cell carcinoma. Int J Mol Sci (2015) 0.94

Stem cell-like circulating tumor cells indicate poor prognosis in gastric cancer. Biomed Res Int (2014) 0.94

G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. Br J Cancer (2014) 0.94

Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis. PLoS One (2013) 0.93

CD133(+) gallbladder carcinoma cells exhibit self-renewal ability and tumorigenicity. World J Gastroenterol (2011) 0.92

Germline polymorphisms in genes involved in the CD44 signaling pathway are associated with clinical outcome in localized gastric adenocarcinoma. Int J Cancer (2011) 0.92

Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology? Stem Cell Rev (2011) 0.92

Gastric cancer stem cells in gastric carcinogenesis, progression, prevention and treatment. World J Gastroenterol (2014) 0.92

Protein kinase C-δ inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo. BMC Cancer (2014) 0.91

miR-106b modulates cancer stem cell characteristics through TGF-β/Smad signaling in CD44-positive gastric cancer cells. Lab Invest (2014) 0.91

Progastrin stimulates colonic cell proliferation via CCK2R- and β-arrestin-dependent suppression of BMP2. Gastroenterology (2013) 0.91

CD44v6 Monoclonal Antibody-Conjugated Gold Nanostars for Targeted Photoacoustic Imaging and Plasmonic Photothermal Therapy of Gastric Cancer Stem-like Cells. Theranostics (2015) 0.91

Cancer Stem Cell Markers CD44, CD133 in Primary Gastric Adenocarcinoma. Int J Mol Cell Med (2014) 0.90

CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer. Cancer Med (2015) 0.89

Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells. World J Gastroenterol (2014) 0.89

Cancer stem cell subsets and their relationships. J Transl Med (2011) 0.89

Expression of CD44 in pancreatic cancer and its significance. Int J Clin Exp Pathol (2015) 0.89

Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop. Oncotarget (2015) 0.89

Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression. Oncotarget (2015) 0.89

Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44⁺ gastric cancer cells via attenuating Wnt signaling. J Gastroenterol (2012) 0.88

Cell separation: Terminology and practical considerations. J Tissue Eng (2012) 0.88

A new method for identifying stem-like cells in esophageal cancer cell lines. J Cancer (2013) 0.88

Gastric cancer stem cells: therapeutic targets. Gastric Cancer (2013) 0.88

Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms. PLoS One (2011) 0.88

Expression of CD176 (Thomsen-Friedenreich antigen) on lung, breast and liver cancer-initiating cells. Int J Exp Pathol (2010) 0.88

Gastric cancer stem cells: evidence, potential markers, and clinical implications. J Gastroenterol (2015) 0.87

Identification of quiescent, stem-like cells in the distal female reproductive tract. PLoS One (2012) 0.87

Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy. Biomed Res Int (2015) 0.87

Malignant phyllodes tumors display mesenchymal stem cell features and aldehyde dehydrogenase/disialoganglioside identify their tumor stem cells. Breast Cancer Res (2014) 0.87

Evaluation of the prognostic value and functional roles of CD44v6 in gastric cancer. J Cancer Res Clin Oncol (2015) 0.86

Characterization of side population cells isolated from the gastric cancer cell line SGC-7901. Oncol Lett (2013) 0.86

Current approaches in identification and isolation of human renal cell carcinoma cancer stem cells. Stem Cell Res Ther (2015) 0.86

EB-virus latent membrane protein 1 potentiates the stemness of nasopharyngeal carcinoma via preferential activation of PI3K/AKT pathway by a positive feedback loop. Oncogene (2015) 0.86

Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges. J Gastroenterol (2011) 0.86

Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges. Gut Pathog (2012) 0.86

CD44 family proteins in gastric cancer: a meta-analysis and narrative review. Int J Clin Exp Med (2015) 0.85

Not all side population cells contain cancer stem-like cells in human gastric cancer cell lines. Dig Dis Sci (2012) 0.84

Articles cited by this

Cancer statistics, 2008. CA Cancer J Clin (2008) 86.74

Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63

Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2006) 24.52

Identification and expansion of human colon-cancer-initiating cells. Nature (2006) 24.44

Identification of a cancer stem cell in human brain tumors. Cancer Res (2003) 24.02

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature (1994) 21.59

Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med (1996) 17.51

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42

Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell (2007) 14.87

Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res (2005) 13.89

Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A (2007) 11.94

Tumor growth need not be driven by rare cancer stem cells. Science (2007) 10.34

Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet (2008) 10.22

CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol (2003) 9.13

Identification of cells initiating human melanomas. Nature (2008) 8.28

Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ (2007) 8.08

A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res (2005) 7.86

A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A (2004) 6.84

Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell (2008) 6.48

The biology of cancer stem cells. Annu Rev Cell Dev Biol (2007) 6.23

Gastric cancer originating from bone marrow-derived cells. Science (2004) 6.04

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest (2008) 5.96

Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med (2006) 5.92

Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Cancer Res (2005) 5.87

Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology (2007) 5.75

Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness. Proc Natl Acad Sci U S A (2006) 4.66

Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology (2006) 4.61

Inflammation, atrophy, and gastric cancer. J Clin Invest (2007) 4.29

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol (1999) 4.04

Myogenic specification of side population cells in skeletal muscle. J Cell Biol (2002) 3.74

Modelling breast cancer: one size does not fit all. Nat Rev Cancer (2007) 3.64

CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res (2008) 3.40

Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells (2007) 3.13

Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology (2000) 2.99

Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med (2006) 2.69

Functional and molecular characterisation of mammary side population cells. Breast Cancer Res (2002) 2.63

Cancer stem cells--old concepts, new insights. Cell Death Differ (2008) 2.56

SP analysis may be used to identify cancer stem cell populations. Exp Cell Res (2006) 2.49

A crucial role for CD44 in inflammation. Trends Mol Med (2001) 2.42

Isolation and characterization of a putative intestinal stem cell fraction from mouse jejunum. Gastroenterology (2005) 2.23

Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology (2005) 1.91

Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res (2008) 1.79

Gastric cancer stem cells. J Clin Oncol (2008) 1.59

Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells. Proc Natl Acad Sci U S A (2007) 1.50

Hepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1. Am J Pathol (2003) 1.49

Prospective identification of a multilineage progenitor in murine stomach epithelium. Gastroenterology (2007) 1.45

Side populations of gastrointestinal cancers are not enriched in stem cells. J Pathol (2008) 1.41

Conditional gene expression and knockdown using lentivirus vectors encoding shRNA. Methods Mol Biol (2008) 1.11

Stem cells and cancer. Semin Cancer Biol (2006) 1.10

Staining embryonic stem cells using monoclonal antibodies to stage-specific embryonic antigens. Methods Mol Biol (2006) 0.92

Molecular biology. Cancer's perpetual source? Science (2007) 0.90

Presence of histamine H2-receptors on human gastric carcinoma cell line MKN-45 and their increase by retinoic acid treatment. Biochem Biophys Res Commun (1991) 0.86

Articles by these authors

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14

Gastric cancer originating from bone marrow-derived cells. Science (2004) 6.04

Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell (2008) 4.43

Inflammation, atrophy, and gastric cancer. J Clin Invest (2007) 4.29

Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell (2011) 3.83

Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell (2009) 3.29

Surgery plus chemotherapy compared with surgery alone for localized squamous cell carcinoma of the thoracic esophagus: a Japan Clinical Oncology Group Study--JCOG9204. J Clin Oncol (2003) 2.86

Verification and unmasking of widely used human esophageal adenocarcinoma cell lines. J Natl Cancer Inst (2010) 2.79

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. Gastroenterology (2008) 2.70

Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells. Nat Med (2010) 2.30

Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell (2012) 2.16

Sequential and concomitant therapy with four drugs is equally effective for eradication of H pylori infection. Clin Gastroenterol Hepatol (2009) 2.15

Socioeconomic and other predictors of colonoscopy preparation quality. Dig Dis Sci (2010) 2.04

Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma. Cancer Res (2004) 1.98

Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology (2003) 1.96

Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol (2005) 1.94

Recurrence of esophageal intestinal metaplasia after endoscopic mucosal resection and radiofrequency ablation of Barrett's esophagus: results from a US Multicenter Consortium. Gastroenterology (2013) 1.92

Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology (2005) 1.91

Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest (2014) 1.90

Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. J Clin Invest (2009) 1.90

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. Cancer Cell (2005) 1.90

A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine. Evid Based Complement Alternat Med (2007) 1.77

MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1). J Biol Chem (2010) 1.76

YAP is a candidate oncogene for esophageal squamous cell carcinoma. Carcinogenesis (2010) 1.75

Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice. Cancer Res (2005) 1.74

Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun (2004) 1.72

MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma. J Hum Genet (2011) 1.71

Global hypomethylation of genomic DNA in cancer-associated myofibroblasts. Cancer Res (2008) 1.70

Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific. Cancer Res (2003) 1.69

TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. J Clin Invest (2002) 1.63

Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia. Gastroenterology (2010) 1.61

Gastric cancer stem cells. J Clin Oncol (2008) 1.59

The prognostic relevance of fascin expression in human gastric carcinoma. Oncology (2004) 1.56

Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A (2014) 1.55

Four cases of panic disorder successfully treated with Kampo (Japanese herbal) medicines: Kami-shoyo-san and Hange-koboku-to. Psychiatry Clin Neurosci (2002) 1.55

Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice. Gastroenterology (2012) 1.54

Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Gastroenterology (2004) 1.52

Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling. Cell Metab (2012) 1.50

Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J Exp Med (2012) 1.49

Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth. Clin Cancer Res (2009) 1.49

Prognostic significance of fascin overexpression in human esophageal squamous cell carcinoma. Clin Cancer Res (2005) 1.48

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J (2009) 1.46

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma. Carcinogenesis (2009) 1.46

TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology (2010) 1.45

The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways. J Biol Chem (2004) 1.43

A dietary restriction influences the progression but not the initiation of MSG-Induced nonalcoholic steatohepatitis. J Med Food (2014) 1.41

Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology (2005) 1.39

The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C: a pilot study. Hum Psychopharmacol (2004) 1.38

The evolution of the cancer niche during multistage carcinogenesis. Nat Rev Cancer (2013) 1.36

Chronic inflammation, the tumor microenvironment and carcinogenesis. Cell Cycle (2009) 1.36

Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin Cancer Res (2003) 1.35

Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice. Am J Pathol (2007) 1.35

Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J Clin Invest (2008) 1.34

Who is using chronic acid suppression therapy and why? Am J Gastroenterol (2003) 1.34

Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology (2009) 1.31

Essential roles of high-mobility group box 1 in the development of murine colitis and colitis-associated cancer. Biochem Biophys Res Commun (2007) 1.30

Neurotrophin receptor p75(NTR) characterizes human esophageal keratinocyte stem cells in vitro. Oncogene (2003) 1.30

The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori. Gastroenterology (2006) 1.29

Usefulness of blood supply visualization by indocyanine green fluorescence for reconstruction during esophagectomy. Esophagus (2011) 1.29

Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma. Oncology (2006) 1.28

Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer. Gastroenterology (2010) 1.28

The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clin Cancer Res (2005) 1.28

Involvement of TSLC1 in progression of esophageal squamous cell carcinoma. Cancer Res (2003) 1.27

Gastrin and cancer: a review. Cancer Lett (2005) 1.26

Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Gastroenterology (2005) 1.26

IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis. Cancer Res (2011) 1.26

Use of murine embryonic fibroblasts to define Toll-like receptor activation and specificity. J Endotoxin Res (2004) 1.25

Identification of ZASC1 encoding a Krüppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. Cancer Res (2003) 1.25

Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells. Oncogene (2004) 1.23

Stem cells in gastroenterology and hepatology. Nat Rev Gastroenterol Hepatol (2009) 1.23

Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy? Semin Cell Dev Biol (2009) 1.23

Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. Cancer Prev Res (Phila) (2011) 1.21

Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing. Gastroenterology (2010) 1.20

Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis. Gastroenterology (2008) 1.18

Expression of CCK2 receptors in the murine pancreas: proliferation, transdifferentiation of acinar cells, and neoplasia. Gastroenterology (2002) 1.14

Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses. Cancer Res (2002) 1.14

Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans. Gastroenterology (2010) 1.13

Prognostic significance of NANOG and KLF4 for breast cancer. Breast Cancer (2012) 1.13

Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis (2002) 1.12

Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis. Gut (2013) 1.12

ABCG2 expression is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma. Oncology (2007) 1.12

Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma. Carcinogenesis (2010) 1.11

Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. Food Chem Toxicol (2012) 1.10