Genetics of Circadian Rhythms.

Circadian Plasticity of Mammalian Inhibitory Interneurons. Neural Plast (2017) 0.75

Mated Drosophila melanogaster females consume more amino acids during the dark phase. PLoS One (2017) 0.75

Obesity and metabolic syndrome in circadian Clock mutant mice. Science (2005) 12.66

Phototransduction by retinal ganglion cells that set the circadian clock. Science (2002) 10.42

Clock mutants of Drosophila melanogaster. Proc Natl Acad Sci U S A (1971) 8.63

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev (2000) 8.19

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature (1999) 7.86

Molecular components of the mammalian circadian clock. Hum Mol Genet (2006) 7.51

Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu Rev Genomics Hum Genet (2004) 7.50

Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol (2001) 6.76

An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science (2001) 6.07

The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell (2002) 6.05

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature (2010) 5.97

A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science (2011) 5.91

Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron (2001) 5.36

Circadian rhythms and the circadian organization of living systems. Cold Spring Harb Symp Quant Biol (1960) 5.34

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell (1998) 5.10

Circadian rhythms from flies to human. Nature (2002) 4.95

High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab (2007) 4.93

AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72

Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature (2005) 4.39

A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci U S A (2014) 4.22

Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors. Science (1999) 3.96

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell (1998) 3.89

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell (1998) 3.86

Shift work and diabetes mellitus: a meta-analysis of observational studies. Occup Environ Med (2014) 3.66

The transcriptional repressor DEC2 regulates sleep length in mammals. Science (2009) 3.12

Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity. Proc Natl Acad Sci U S A (2002) 3.03

vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell (2003) 3.01

Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell (2007) 2.63

Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell (2004) 2.62

Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation. Sleep (2005) 2.61

Block in nuclear localization of period protein by a second clock mutation, timeless. Science (1994) 2.37

Circadian organization of behavior and physiology in Drosophila. Annu Rev Physiol (2010) 2.36

The circadian clock mutation alters sleep homeostasis in the mouse. J Neurosci (2000) 2.17

Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells. Mol Cell Biol (2002) 2.13

Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med (2012) 2.13

Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock. Neuron (1995) 2.12

Organization of the Drosophila circadian control circuit. Curr Biol (2008) 2.11

Effects of sleep and circadian rhythm on human circulating immune cells. J Immunol (1997) 2.08

Molecular genetic analysis of circadian timekeeping in Drosophila. Adv Genet (2011) 2.04

Sleep and circadian rhythms: key components in the regulation of energy metabolism. FEBS Lett (2007) 2.03

Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci U S A (2013) 1.94

Linking neural activity and molecular oscillations in the SCN. Nat Rev Neurosci (2011) 1.92

Circadian control of the immune system. Nat Rev Immunol (2013) 1.90

Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int J Obes (Lond) (2007) 1.88

Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock. J Biol Chem (2002) 1.87

Metabolism and circadian rhythms--implications for obesity. Endocr Rev (2009) 1.82

The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation. J Biol Chem (2003) 1.76

The implications of multiple circadian clock origins. PLoS Biol (2009) 1.61

Circadian timing in cancer treatments. Annu Rev Pharmacol Toxicol (2010) 1.58

The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. J Neurosci (2005) 1.54

Circadian control of membrane excitability in Drosophila melanogaster lateral ventral clock neurons. J Neurosci (2008) 1.53

Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock. Cell (2015) 1.50

Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47

Circadian disruption, shift work and the risk of cancer: a summary of the evidence and studies in Seattle. Cancer Causes Control (2006) 1.37

Neurotransmitters of the retino-hypothalamic tract. Cell Tissue Res (2002) 1.36

Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia. Blood (2005) 1.35

Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1). Genes Dev (2007) 1.33

Molecular pharmacology, regulation and function of mammalian melatonin receptors. Front Biosci (2003) 1.32

Circadian rhythm disruption in cancer biology. Mol Med (2012) 1.31

Mistimed sleep disrupts circadian regulation of the human transcriptome. Proc Natl Acad Sci U S A (2014) 1.30

In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD. J Neurosci (2005) 1.24

Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms. Sci Signal (2009) 1.21

Plasticity of the intrinsic period of the human circadian timing system. PLoS One (2007) 1.21

Expression of the circadian clock genes Per1 and Per2 in sporadic and familial breast tumors. Neoplasia (2007) 1.21

Regulating a circadian clock's period, phase and amplitude by phosphorylation: insights from Drosophila. J Biochem (2006) 1.19

Regulation of circadian gene expression in liver by systemic signals and hepatocyte oscillators. Cold Spring Harb Symp Quant Biol (2007) 1.14

AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. PLoS One (2011) 1.11

Circadian variation of the response of T cells to antigen. J Immunol (2011) 1.07

Circadian and wakefulness-sleep modulation of cognition in humans. Front Mol Neurosci (2012) 1.05

Circadian gating of S phase in human ovarian cancer. Cancer Res (1987) 1.05

Hofbauer-Buchner eyelet affects circadian photosensitivity and coordinates TIM and PER expression in Drosophila clock neurons. J Biol Rhythms (2007) 1.03

Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle (2014) 1.00

Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s). Proc Natl Acad Sci U S A (2012) 0.99

The thymus is similar to the testis in its pattern of circadian clock gene expression. J Biol Rhythms (2005) 0.95

Expression of clock gene products in the suprachiasmatic nucleus in relation to circadian behaviour. Novartis Found Symp (2003) 0.94

Correlative association between N-methyl-D-aspartate receptor-mediated expression of period genes in the suprachiasmatic nucleus and phase shifts in behavior with photic entrainment of clock in hamsters. Mol Pharmacol (2000) 0.91

Genetic basis of human circadian rhythm disorders. Exp Neurol (2012) 0.90

The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. Nat Clin Pract Neurol (2008) 0.88

Regulation of core clock genes in human islets. Metabolism (2012) 0.87

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila. PLoS Genet (2013) 0.87

DEC1/STRA13/SHARP2 and DEC2/SHARP1 coordinate physiological processes, including circadian rhythms in response to environmental stimuli. Curr Top Dev Biol (2014) 0.86

Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. PLoS One (2011) 0.84

Time-related dynamics of variation in core clock gene expression levels in tissues relevant to the immune system. Int J Immunopathol Pharmacol (2012) 0.84

Molecular mechanism of circadian rhythmicity of seizures in temporal lobe epilepsy. Front Cell Neurosci (2012) 0.82

Transcriptional regulation via nuclear receptor crosstalk required for the Drosophila circadian clock. Curr Biol (2015) 0.82

An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila. Nat Commun (2014) 0.81

Temperature compensation of the circadian clock: a role for the morning loop. Plant Cell (2010) 0.76