Circadian organization of behavior and physiology in Drosophila.

PubWeight™: 2.36‹?› | Rank: Top 2%

🔗 View Article (PMC 2887282)

Published in Annu Rev Physiol on January 01, 2010

Authors

Ravi Allada1, Brian Y Chung

Author Affiliations

1: Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA. r-allada@northwestern.edu

Articles citing this

(truncated to the top 100)

The monarch butterfly genome yields insights into long-distance migration. Cell (2011) 3.51

Molecular genetic analysis of circadian timekeeping in Drosophila. Adv Genet (2011) 2.04

The circadian clock interacts with metabolic physiology to influence reproductive fitness. Cell Metab (2011) 1.96

Genome-wide analysis of light- and temperature-entrained circadian transcripts in Caenorhabditis elegans. PLoS Biol (2010) 1.68

Calcitonin gene-related peptide neurons mediate sleep-specific circadian output in Drosophila. Curr Biol (2014) 1.61

Deep sequencing the circadian and diurnal transcriptome of Drosophila brain. Genome Res (2012) 1.47

Navigational mechanisms of migrating monarch butterflies. Trends Neurosci (2010) 1.42

NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed. Cell (2011) 1.41

Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem (2010) 1.34

REVEILLE8 and PSEUDO-REPONSE REGULATOR5 form a negative feedback loop within the Arabidopsis circadian clock. PLoS Genet (2011) 1.29

Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue. PLoS Genet (2012) 1.27

Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit. Cell (2012) 1.27

Loss of circadian clock accelerates aging in neurodegeneration-prone mutants. Neurobiol Dis (2011) 1.13

A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Cell (2015) 1.10

Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila. Neuron (2012) 1.09

Dual PDF signaling pathways reset clocks via TIMELESS and acutely excite target neurons to control circadian behavior. PLoS Biol (2014) 1.07

Identification of a circadian output circuit for rest:activity rhythms in Drosophila. Cell (2014) 1.06

Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans. Neuron (2013) 1.05

Effects of aging on the molecular circadian oscillations in Drosophila. Chronobiol Int (2012) 1.04

Fitness costs of disrupting circadian rhythms in malaria parasites. Proc Biol Sci (2011) 1.00

Circadian regulation of glutathione levels and biosynthesis in Drosophila melanogaster. PLoS One (2012) 1.00

Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila. Nat Commun (2012) 0.99

Drosophila TRPA1 functions in temperature control of circadian rhythm in pacemaker neurons. J Neurosci (2013) 0.99

NEMO kinase contributes to core period determination by slowing the pace of the Drosophila circadian oscillator. Curr Biol (2011) 0.97

Circadian rhythm of temperature preference and its neural control in Drosophila. Curr Biol (2012) 0.95

Peripheral circadian rhythms and their regulatory mechanism in insects and some other arthropods: a review. J Comp Physiol B (2012) 0.92

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease. Dis Model Mech (2014) 0.92

In vivo circadian oscillation of dCREB2 and NF-κB activity in the Drosophila nervous system. PLoS One (2012) 0.91

Sleep interacts with aβ to modulate intrinsic neuronal excitability. Curr Biol (2015) 0.90

Dopamine dynamics and signaling in Drosophila: an overview of genes, drugs and behavioral paradigms. Exp Anim (2014) 0.90

Aging signaling pathways and circadian clock-dependent metabolic derangements. Trends Endocrinol Metab (2013) 0.90

WIDE AWAKE mediates the circadian timing of sleep onset. Neuron (2014) 0.90

The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs. Cell Metab (2012) 0.90

Neurogenomic signatures of spatiotemporal memories in time-trained forager honey bees. J Exp Biol (2011) 0.89

CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila. Genes Dev (2012) 0.89

Pigment-dispersing factor modulates pheromone production in clock cells that influence mating in drosophila. Neuron (2013) 0.89

UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila. PLoS One (2013) 0.88

The molecular clockwork of the fire ant Solenopsis invicta. PLoS One (2012) 0.87

CULLIN-3 controls TIMELESS oscillations in the Drosophila circadian clock. PLoS Biol (2012) 0.87

Regulation of insect behavior via the insulin-signaling pathway. Front Physiol (2013) 0.87

Studying circadian rhythms in Drosophila melanogaster. Methods (2014) 0.86

period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection. Curr Biol (2015) 0.86

The central clock neurons regulate lipid storage in Drosophila. PLoS One (2011) 0.86

Adult circadian behavior in Drosophila requires developmental expression of cycle, but not period. PLoS Genet (2011) 0.86

The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila. EMBO Rep (2011) 0.86

Prediction of the protein components of a putative Calanus finmarchicus (Crustacea, Copepoda) circadian signaling system using a de novo assembled transcriptome. Comp Biochem Physiol Part D Genomics Proteomics (2013) 0.85

dyschronic, a Drosophila homolog of a deaf-blindness gene, regulates circadian output and Slowpoke channels. PLoS Genet (2012) 0.84

Clk post-transcriptional control denoises circadian transcription both temporally and spatially. Nat Commun (2015) 0.84

Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies. Handb Exp Pharmacol (2014) 0.84

The Genome of Winter Moth (Operophtera brumata) Provides a Genomic Perspective on Sexual Dimorphism and Phenology. Genome Biol Evol (2015) 0.84

Footprints in time: comparative quantitative trait loci mapping of the pitcher-plant mosquito, Wyeomyia smithii. Proc Biol Sci (2012) 0.83

Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet (2016) 0.83

Unraveling the complexities of circadian and sleep interactions with memory formation through invertebrate research. Front Syst Neurosci (2014) 0.82

Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins. PLoS One (2012) 0.82

A database of circadian and diel rhythmic gene expression in the yellow fever mosquito Aedes aegypti. BMC Genomics (2014) 0.82

A novel pathway for sensory-mediated arousal involves splicing of an intron in the period clock gene. Sleep (2015) 0.82

Circadian genes differentially affect tolerance to ethanol in Drosophila. Alcohol Clin Exp Res (2013) 0.82

Positive geotactic behaviors induced by geomagnetic field in Drosophila. Mol Brain (2016) 0.82

Time to taste: circadian clock function in the Drosophila gustatory system. Fly (Austin) (2010) 0.81

Phosphorylation of a central clock transcription factor is required for thermal but not photic entrainment. PLoS Genet (2014) 0.80

Synergistic interactions between the molecular and neuronal circadian networks drive robust behavioral circadian rhythms in Drosophila melanogaster. PLoS Genet (2014) 0.80

Genomic identification of a putative circadian system in the cladoceran crustacean Daphnia pulex. Comp Biochem Physiol Part D Genomics Proteomics (2011) 0.80

E and M circadian pacemaker neurons use different PDF receptor signalosome components in drosophila. J Biol Rhythms (2013) 0.80

Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue. Elife (2016) 0.79

A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein. Genetics (2011) 0.79

An automated system for quantitative analysis of Drosophila larval locomotion. BMC Dev Biol (2015) 0.78

Potent social synchronization can override photic entrainment of circadian rhythms. Nat Commun (2016) 0.78

dTRPA1 Modulates Afternoon Peak of Activity of Fruit Flies Drosophila melanogaster. PLoS One (2015) 0.77

Electroencephalographic signals synchronize with behaviors and are sexually dimorphic during the light-dark cycle in reproductive frogs. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2013) 0.77

The FlyCatwalk: a high-throughput feature-based sorting system for artificial selection in Drosophila. G3 (Bethesda) (2015) 0.77

Rhythmic control of activity and sleep by class B1 GPCRs. Crit Rev Biochem Mol Biol (2014) 0.77

Contribution of Drosophila TRPA1-expressing neurons to circadian locomotor activity patterns. PLoS One (2013) 0.77

PDF Signaling Is an Integral Part of the Drosophila Circadian Molecular Oscillator. Cell Rep (2016) 0.77

A role for timely nuclear translocation of clock repressor proteins in setting circadian clock speed. Exp Neurobiol (2014) 0.77

Physiological and molecular mechanisms underlying photoperiodism in the spider mite: comparisons with insects. J Comp Physiol B (2016) 0.76

Evolutionary divergence of core and post-translational circadian clock genes in the pitcher-plant mosquito, Wyeomyia smithii. BMC Genomics (2015) 0.76

Aging studies in Drosophila melanogaster. Methods Mol Biol (2013) 0.76

Circadian Oscillators: Around the Transcription-Translation Feedback Loop and on to Output. Trends Biochem Sci (2016) 0.76

mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression. Proc Natl Acad Sci U S A (2016) 0.76

Genetics of Circadian Rhythms. Sleep Med Clin (2015) 0.76

The MAP kinase p38 is part of Drosophila melanogaster's circadian clock. PLoS Genet (2014) 0.76

Design and analysis of temperature preference behavior and its circadian rhythm in Drosophila. J Vis Exp (2014) 0.76

Nuclear envelope regulates the circadian clock. Nucleus (2015) 0.75

Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say? Front Neurol (2015) 0.75

miR-124 Regulates Diverse Aspects of Rhythmic Behavior in Drosophila. J Neurosci (2016) 0.75

Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. Fly (Austin) (2015) 0.75

Genetic architecture underlying morning and evening circadian phenotypes in fruit flies Drosophila melanogaster. Heredity (Edinb) (2013) 0.75

Social Experience Is Sufficient to Modulate Sleep Need of Drosophila without Increasing Wakefulness. PLoS One (2016) 0.75

Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila. J Biol Rhythms (2016) 0.75

Characterization and Evolution of the Spotted Gar Retina. J Exp Zool B Mol Dev Evol (2016) 0.75

Context-dependent expression of the foraging gene in field colonies of ants: the interacting roles of age, environment and task. Proc Biol Sci (2016) 0.75

Absorption-mode Fourier transform mass spectrometry: the effects of apodization and phasing on modified protein spectra. J Am Soc Mass Spectrom (2013) 0.75

CRTC Potentiates Light-independent timeless Transcription to Sustain Circadian Rhythms in Drosophila. Sci Rep (2016) 0.75

GSK-3 and CK2 Kinases Converge on Timeless to Regulate the Master Clock. Cell Rep (2016) 0.75

Circadian rhythms of crawling and swimming in the nudibranch mollusc Melibe leonina. Biol Bull (2014) 0.75

Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD. Genes Dev (2016) 0.75

Photic preference of the short-tailed opossum (Monodelphis domestica). Neuroscience (2014) 0.75

Effective trapping of fruit flies with cultures of metabolically modified acetic acid bacteria. Appl Environ Microbiol (2015) 0.75

The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity. Front Cell Neurosci (2017) 0.75

Rhodnius prolixus and R. robustus (Hemiptera: Reduviidae) nymphs show different locomotor patterns on an automated recording system. Parasit Vectors (2016) 0.75

Articles cited by this

(truncated to the top 100)

ON TEMPERATURE INDEPENDENCE IN THE CLOCK SYSTEM CONTROLLING EMERGENCE TIME IN DROSOPHILA. Proc Natl Acad Sci U S A (1954) 10.59

The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet (2008) 7.65

An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science (2001) 6.07

Correlates of sleep and waking in Drosophila melanogaster. Science (2000) 5.89

Rest in Drosophila is a sleep-like state. Neuron (2000) 5.72

Independent photoreceptive circadian clocks throughout Drosophila. Science (1997) 5.18

A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell (1999) 5.14

Microarray analysis and organization of circadian gene expression in Drosophila. Cell (2001) 4.59

Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature (2005) 4.39

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell (1998) 3.89

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell (1998) 3.86

Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature (2002) 3.75

Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock. Cell (2002) 3.53

Sleep in Drosophila is regulated by adult mushroom bodies. Nature (2006) 3.36

Circadian regulation of gene expression systems in the Drosophila head. Neuron (2001) 3.35

A resetting signal between Drosophila pacemakers synchronizes morning and evening activity. Nature (2005) 3.35

Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J Neurosci (2002) 3.34

Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature (2002) 3.15

The transcriptional repressor DEC2 regulates sleep length in mammals. Science (2009) 3.12

Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc Natl Acad Sci U S A (2000) 3.11

vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell (2003) 3.01

Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J Neurosci (1990) 2.93

Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metab (2008) 2.85

PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. Neuron (2008) 2.81

A dynamic role for the mushroom bodies in promoting sleep in Drosophila. Nature (2006) 2.79

Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron (2008) 2.73

Genome-wide transcriptional orchestration of circadian rhythms in Drosophila. J Biol Chem (2002) 2.64

Use-dependent plasticity in clock neurons regulates sleep need in Drosophila. Science (2009) 2.63

Masking: history, definitions, and measurement. Chronobiol Int (1999) 2.62

The Drosophila circadian network is a seasonal timer. Cell (2007) 2.62

The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell (2007) 2.54

Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain. Proc Natl Acad Sci U S A (2008) 2.43

Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science (2007) 2.42

PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science (2006) 2.37

Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster. Proc Natl Acad Sci U S A (2002) 2.33

PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes Dev (2006) 2.31

PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors. Neuron (2005) 2.30

Physiological correlates of prolonged sleep deprivation in rats. Science (1983) 2.26

Large ventral lateral neurons modulate arousal and sleep in Drosophila. Curr Biol (2008) 2.26

Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling. EMBO J (1994) 2.23

Circadian rhythms in olfactory responses of Drosophila melanogaster. Nature (1999) 2.22

Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila. Curr Biol (2004) 2.20

The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior. Cell (2000) 2.18

Drosophila ebony activity is required in glia for the circadian regulation of locomotor activity. Neuron (2007) 2.17

A subset of dorsal neurons modulates circadian behavior and light responses in Drosophila. Neuron (2007) 2.13

Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF. Neuron (2005) 2.12

Organization of the Drosophila circadian control circuit. Curr Biol (2008) 2.11

Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J Neurosci (1992) 2.10

Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind, or both. J Biol Rhythms (1993) 2.04

Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron (2002) 2.03

A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior. Neuron (2005) 2.03

BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nat Neurosci (2006) 2.01

Natural variation in the splice site strength of a clock gene and species-specific thermal adaptation. Neuron (2008) 1.99

A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nat Neurosci (2001) 1.95

Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons. J Neurophysiol (2007) 1.94

Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of ecdysis behavior. Development (2003) 1.93

Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands. Curr Biol (2009) 1.90

Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. J Biol Rhythms (2003) 1.85

A new role for cryptochrome in a Drosophila circadian oscillator. Nature (2001) 1.85

The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior. Genes Dev (2002) 1.82

Retracted PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila. PLoS Biol (2007) 1.80

Circadian rhythms of female mating activity governed by clock genes in Drosophila. Proc Natl Acad Sci U S A (2001) 1.78

A molecular basis for natural selection at the timeless locus in Drosophila melanogaster. Science (2007) 1.77

Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron (2002) 1.76

Circadian pacemaker neurons transmit and modulate visual information to control a rapid behavioral response. Neuron (2005) 1.75

Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Genes Dev (2007) 1.73

Unearthing the phylogenetic roots of sleep. Curr Biol (2008) 1.71

Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J Neurosci (2004) 1.71

Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature (2008) 1.71

The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock. Genes Dev (2008) 1.70

Genes expressed in the Drosophila head reveal a role for fat cells in sex-specific physiology. EMBO J (2002) 1.66

A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock. Genes Dev (2007) 1.66

Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila. Curr Biol (2007) 1.66

Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. Proc Natl Acad Sci U S A (2006) 1.63

A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK. Science (2001) 1.61

Control of daily transcript oscillations in Drosophila by light and the circadian clock. PLoS Genet (2006) 1.58

The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster. Proc Natl Acad Sci U S A (1995) 1.58

Spatial and temporal expression of the period gene in Drosophila melanogaster. Genes Dev (1988) 1.58

Transplantation of a circadian pacemaker in Drosophila. Nature (1979) 1.56

Drosophila clock can generate ectopic circadian clocks. Cell (2003) 1.55

The neuropeptide pigment-dispersing factor adjusts period and phase of Drosophila's clock. J Neurosci (2009) 1.55

Meta-analysis of Drosophila circadian microarray studies identifies a novel set of rhythmically expressed genes. PLoS Comput Biol (2007) 1.55

Circadian control of membrane excitability in Drosophila melanogaster lateral ventral clock neurons. J Neurosci (2008) 1.53

The Drosophila dCREB2 gene affects the circadian clock. Neuron (1999) 1.53

A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock function. Mol Cell Biol (2007) 1.52

Drosophila CRYPTOCHROME is a circadian transcriptional repressor. Curr Biol (2006) 1.50

Cryptochrome, compound eyes, Hofbauer-Buchner eyelets, and ocelli play different roles in the entrainment and masking pathway of the locomotor activity rhythm in the fruit fly Drosophila melanogaster. J Biol Rhythms (2003) 1.50

Circadian regulation in the ability of Drosophila to combat pathogenic infections. Curr Biol (2008) 1.50

Nocturnal male sex drive in Drosophila. Curr Biol (2007) 1.49

Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock. PLoS Biol (2007) 1.47

Interactions between circadian rhythm and immunity in Drosophila melanogaster. Curr Biol (2007) 1.47

Regulation of feeding behaviour and locomotor activity by takeout in Drosophila. J Exp Biol (2007) 1.46

A role for the adult fat body in Drosophila male courtship behavior. PLoS Genet (2007) 1.45

Integration of light and temperature in the regulation of circadian gene expression in Drosophila. PLoS Genet (2007) 1.45

Temporal mating isolation driven by a behavioral gene in Drosophila. Curr Biol (2003) 1.44

The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila. Curr Biol (2009) 1.43

Circadian remodeling of neuronal circuits involved in rhythmic behavior. PLoS Biol (2008) 1.41

Circadian transcription contributes to core period determination in Drosophila. PLoS Biol (2008) 1.40

Circadian control of eclosion: interaction between a central and peripheral clock in Drosophila melanogaster. Curr Biol (2003) 1.40

A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude. EMBO J (2003) 1.38