Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation.

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Published in Nat Struct Mol Biol on November 16, 2015

Authors

Saskia Polling1,2, Angelique R Ormsby1,2, Rebecca J Wood1,2, Kristie Lee3, Cheryl Shoubridge3, James N Hughes4, Paul Q Thomas4, Michael D W Griffin1,2, Andrew F Hill5, Quill Bowden6, Till Böcking6,7, Danny M Hatters1,2,7

Author Affiliations

1: Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia.
2: Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.
3: Robinson Research Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia.
4: School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia.
5: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
6: Single Molecule Science and Department of Anatomy, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
7: Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Australia.

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