Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26572092)

Published in Inhal Toxicol on November 16, 2015

Authors

Varsha Dhamankar1, Mahfoud Assem1, Maureen D Donovan1

Author Affiliations

1: a Division of Pharmaceutics and Translational Therapeutics , College of Pharmacy, University of Iowa , Iowa City , IA , USA.

Articles cited by this

NIH Image to ImageJ: 25 years of image analysis. Nat Methods (2012) 84.41

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res (2002) 76.95

Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc (2008) 62.52

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther (1994) 5.22

Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol (2002) 2.74

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol (2006) 2.59

Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res (2000) 1.86

Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity. Pharmacogenetics (1995) 1.50

Regulation of the cytochrome P450 2A genes. Toxicol Appl Pharmacol (2004) 1.29

Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. Mol Endocrinol (1989) 1.24

Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J Biochem Mol Toxicol (1999) 1.23

Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms. Pharmacogenomics (2008) 1.22

Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metab Rev (2010) 1.15

Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2. AAPS J (2009) 1.08

Expression of CYP2A genes in human liver and extrahepatic tissues. Biochem Pharmacol (1999) 1.04

P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer. Xenobiotica (1994) 1.03

Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa. Drug Metab Dispos (2005) 1.02

Expression of CYP1A1 and CYP1A2 genes in human liver. Pharmacogenetics (1993) 1.01

Immunohistochemical study of cytochrome P450 2C and 3A in human non-neoplastic and neoplastic tissues. Virchows Arch (1999) 1.00

Validation of excised bovine nasal mucosa as in vitro model to study drug transport and metabolic pathways in nasal epithelium. J Pharm Sci (2000) 0.95

Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes. Mutat Res (1997) 0.94

Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa. Biochem Pharmacol (2003) 0.92

Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue. Neuroreport (1992) 0.92

Expression of CYP2A genes in rodent and human nasal mucosa. Drug Metab Dispos (1996) 0.91

Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog. Chem Biol Interact (2001) 0.91

Nasal cavity enzymes involved in xenobiotic metabolism: effects on the toxicity of inhalants. Crit Rev Toxicol (1991) 0.90

Drug metabolism in the nasal cavity: relevance to toxicology. Drug Metab Rev (1993) 0.89

Cytochrome P-450 dependent monooxygenase activity in rat nasal epithelial membranes. Toxicol Lett (1982) 0.88

Localization of cytochrome P450 CYP2S1 expression in human tissues by in situ hybridization and immunohistochemistry. J Histochem Cytochem (2005) 0.88

Regulation of cytochrome P450 gene expression in the olfactory mucosa. Chem Biol Interact (2004) 0.88

Microsmatic primates: reconsidering how and when size matters. Anat Rec B New Anat (2004) 0.86

Expression of biotransformation enzymes in human fetal olfactory mucosa: potential roles in developmental toxicity. Toxicol Appl Pharmacol (2000) 0.86

Odorant metabolism catalyzed by olfactory mucosal enzymes influences peripheral olfactory responses in rats. PLoS One (2013) 0.85

Odorant-binding proteins and xenobiotic metabolizing enzymes: implications in olfactory perireceptor events. Anat Rec (Hoboken) (2013) 0.84

Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa. J Histochem Cytochem (1993) 0.83

Metabolism-dependent activation and toxicity of chemicals in nasal glands. Mutat Res (1997) 0.83

Immunohistochemical localization of a cytochrome P-450 isozyme in human nasal mucosa: age-related trends. Ann Otol Rhinol Laryngol (1993) 0.83

Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices. Xenobiotica (2003) 0.83

Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs. Xenobiotica (2013) 0.83

Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa. Drug Metab Dispos (2005) 0.81

Permeation and pathways of human calcitonin (hCT) across excised bovine nasal mucosa. Peptides (1998) 0.81

Effects of typical inducers on olfactory xenobiotic-metabolizing enzyme, transporter, and transcription factor expression in rats. Drug Metab Dispos (2010) 0.81

Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver. Drug Metab Dispos (2008) 0.80

Expression of CYP2A3 mRNA and its regulation by 3-methylcholanthrene, pyrazole, and beta-ionone in rat tissues. Braz J Med Biol Res (2003) 0.79

Expression of CYP3A4 mRNA is correlated with CYP3A4 protein level and metabolic activity in human liver. J Pharmacol Sci (2004) 0.79

Effect of diet and nutrition on the expression of cytochromes P450. Xenobiotica (1999) 0.79

Defence mechanisms of olfactory neuro-epithelium: mucosa regeneration, metabolising enzymes and transporters. B-ENT (2009) 0.78

Intranasal delivery--modification of drug metabolism and brain disposition. Pharm Res (2010) 0.78

Proteolysis of human calcitonin in excised bovine nasal mucosa: elucidation of the metabolic pathway by liquid secondary ionization mass spectrometry (LSIMS) and matrix assisted laser desorption ionization mass spectrometry (MALDI). Pharm Res (1996) 0.77

Association between CYP1A2 gene single nucleotide polymorphisms and clinical responses to clozapine in patients with treatment-resistant schizophrenia. Acta Neuropsychiatr (2013) 0.77

Selective inactivation of rat and bovine olfactory cytochrome P450 by three haloethanes. Toxicol Lett (2001) 0.76

A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver. Biochem Pharmacol (2001) 0.76

When the nose must remain responsive: glutathione conjugation of the mammary pheromone in the newborn rabbit. Chem Senses (2014) 0.76

Gene expression and enzyme function of two cytochrome P450 3A isoenzymes in rat and cattle precision cut liver slices. Xenobiotica (2015) 0.76

Cytochrome P450 1A-dependent activities in deer, cattle and horses. J Vet Med Sci (2010) 0.76

Characterization of xenobiotic metabolizing enzymes in bovine small intestinal mucosa. J Vet Pharmacol Ther (2010) 0.76

Proposed new nomenclature for Bos taurus cytochromes P450 involved in xenobiotic drug metabolism. J Vet Pharmacol Ther (2010) 0.76

High expression of the mRNA of cytochrome P450 and phase II enzymes in the lung and kidney tissues of cattle. Animal (2010) 0.76